Quantification of cerebral blood flow in nonhuman primates using arterial spin labeling and a two-compartment model

Zappe, Anne Catherin; Reichold, Johannes; Burger, Cyrill; Weber, Bruno; Buck, Alfred; Pfeuffer, Josef; Logothetis, Nikos K.

doi:10.1016/j.mri.2006.11.028

Cited by 21 publications

(23 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The findings were consistent with the previous human brain studies [9][10][11]. It is similar to the activity of normal human brain that rCBF in cortex is significantly higher than that in white matter.…”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

Analysis of Cerebral Hemodynamics in Healthy Adult Rhesus with Dynamic Susceptibility Contrast Perfusion (DSC-MR) Imaging

Zhao

et al. 2016

Appl Magn Reson

View full text Add to dashboard Cite

The aim of this study was to investigate hemodynamic differences in different brain regions of normal macaque brains using dynamic susceptibility contrast (DSC) perfusion magnetic resonance (MR) imaging. Twelve male subjects were selected for DSC perfusion MR imaging (age 4-8 years). The relative cerebral blood volume (rCBV) and relative cerebral blood flow (rCBF) images were obtained by post-processing software. The values of rCBV and rCBF were recorded from the frontal cortex, parietal cortex, occipital cortex, head of caudate nucleus, posterior limb of internal capsule, thalamus, midbrain, pons, cerebellar, semioval area and splenium of the corpus callosum. The figures of rCBV and rCBF can clearly demonstrate the hemodynamic differences in various cerebral parts. It has been noted that rCBV and rCBF values have no significant difference between the right and left hemisphere (P [ 0.05). The values of rCBF from cerebral cortex were significantly higher than that of white matter (P \ 0.05). The values of rCBF were different (P \ 0.05) at frontal cortex, parietal cortex and occipital cortex. However, the highest value has been observed in occipital cortex compared with the others (P \ 0.05). We observed higher correlation coefficient between the rCBF and rCBV (r = 0.92, P \ 0.05). Results from this study show that the hemodynamic characteristics of healthy adult rhesus are similar to those of normal human studies. Moreover, the blood flow of cortex is found significantly higher than white matter & Jun Pu pujun88@yeah.net

show abstract

Section: Discussionsupporting

confidence: 92%

“…Mild hypothermia has been widely used nowadays and deep hypothermia is still being studied. As primate animals are close to humans, rhesus has been studied gradually since 2003 [5][6][7][8][9][10][11]. Theoretically, low brain temperature could improve the brain tolerance to hypoxia.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Cerebral Hemodynamics in Healthy Adult Rhesus with Dynamic Susceptibility Contrast Perfusion (DSC-MR) Imaging

Zhao

et al. 2016

Appl Magn Reson

View full text Add to dashboard Cite

show abstract

“…Arterial spin labelling (ASL) employs magnetically labelled endogenous arterial blood water to quantify cerebral perfusion. ASL can also measure arterial arrival time (AAT), the time taken for blood to travel from the labelling slab to the tissue of interest (Wang et al, 2003; Zappe et al, 2007). AAT is longest in distal branches, especially in border zone (or watershed) areas (Hendrikse et al, 2008; Petersen et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Arterial spin labelling reveals prolonged arterial arrival time in idiopathic Parkinson's disease

Al–Bachari

Parkes

Vidyasagar

et al. 2014

NeuroImage: Clinical

View full text Add to dashboard Cite

Idiopathic Parkinson's disease (IPD) is the second most common neurodegenerative disease, yet effective disease modifying treatments are still lacking. Neurodegeneration involves multiple interacting pathological pathways. The extent to which neurovascular mechanisms are involved is not well defined in IPD. We aimed to determine whether novel magnetic resonance imaging (MRI) techniques, including arterial spin labelling (ASL) quantification of cerebral perfusion, can reveal altered neurovascular status (NVS) in IPD.Fourteen participants with IPD (mean ± SD age 65.1 ± 5.9 years) and 14 age and cardiovascular risk factor matched control participants (mean ± SD age 64.6 ± 4.2 years) underwent a 3T MRI scan protocol. ASL images were collected before, during and after a 6 minute hypercapnic challenge. FLAIR images were used to determine white matter lesion score. Quantitative images of cerebral blood flow (CBF) and arterial arrival time (AAT) were calculated from the ASL data both at rest and during hypercapnia. Cerebrovascular reactivity (CVR) images were calculated, depicting the change in CBF and AAT relative to the change in end-tidal CO2.A significant (p = 0.005) increase in whole brain averaged baseline AAT was observed in IPD participants (mean ± SD age 1532 ± 138 ms) compared to controls (mean ± SD age 1335 ± 165 ms). Voxel-wise analysis revealed this to be widespread across the brain. However, there were no statistically significant differences in white matter lesion score, CBF, or CVR between patients and controls. Regional CBF, but not AAT, in the IPD group was found to correlate positively with Montreal cognitive assessment (MoCA) scores. These findings provide further evidence of alterations in NVS in IPD.

show abstract

“…The diagnosis of hyperperfusion syndrome required (a) seizure, decrease in level of consciousness, and/or development of focal neurologic signs such as motor weakness and (b) hyperperfusion at SPECT performed after CEA without fi ndings of any additional ischemic lesion at postoperative computed tomography (CT) or T1-and T2-weighted MR imaging. ( 34,35 ). However, arterial spin labeling can be used to measure only CBF, and it requires administration of acetazolamide to quantify cerebral perfusion reserve ( 34 ).…”

Section: Intraoperative and Postoperative Managementmentioning

confidence: 99%

“…( 34,35 ). However, arterial spin labeling can be used to measure only CBF, and it requires administration of acetazolamide to quantify cerebral perfusion reserve ( 34 ). Although blood oxygen level-dependent imaging can help estimate cerebral perfusion reserve ( 35 ), whether its fi ndings predict cerebral hyperperfusion after CEA remains unclear.…”

Section: Intraoperative and Postoperative Managementmentioning

confidence: 99%

Brain Temperature Measured by Using Proton MR Spectroscopy Predicts Cerebral Hyperperfusion after Carotid Endarterectomy

Murakami

Ogasawara²,

Yoshioka³

et al. 2010

Radiology

View full text Add to dashboard Cite

Purpose:To determine whether brain temperature measured by using preoperative proton magnetic resonance (MR) spectroscopy could help identify patients at risk for cerebral hyperperfusion after carotid endarterectomy (CEA). Materials and Methods:Institutional review board approval and informed consent were obtained. Acquisition of proton MR spectroscopic data by using point-resolved spectroscopy without water suppression was performed before CEA in the bilateral cerebral hemispheres of 84 patients with unilateral internal carotid artery stenosis ( Ն 70%) and without contralateral internal carotid artery steno-occlusive disease. Brain temperature was calculated from the chemical shift difference between water and N -acetylaspartate signals at proton MR spectroscopy. Cerebral blood fl ow (CBF) was also measured by using single photon emission computed tomography and N -isopropyl-p -[ 123 I]-iodoamphetamine before and immediately after CEA and on the 3rd postoperative day. The relationship between each variable and the development of post-CEA hyperperfusion (CBF increase Ն 100% compared with preoperative values) was evaluated with univariate statistical analysis followed by multivariate analysis. Results:A linear correlation was observed between preoperative brain temperature difference (the value in the affected hemisphere minus the value in the contralateral hemisphere) and increases in CBF immediately after CEA ( r = 0.763 and P , .001) when the preoperative brain temperature difference was greater than 0. Cerebral hyperperfusion immediately after CEA was observed in nine patients (11%). Elevated preoperative brain temperature difference was the only signifi cant independent predictor of post-CEA hyperperfusion. When elevated brain temperature difference was defi ned as a marker of hemodynamic impairment in the affected cerebral hemisphere, use of preoperative brain temperature difference resulted in 100% sensitivity and 87% specifi city, with a 47% positive predictive value and a 100% negative predictive value for the prediction of post-CEA hyperperfusion. Hyperperfusion syndrome developed on the 3rd and 4th postoperative days in two of the nine patients who exhibited hyperperfusion immediately after CEA. Conclusion:Brain temperature measured by using preoperative proton MR spectroscopy may help identify patients at risk for post-CEA cerebral hyperperfusion.q RSNA, 2010

show abstract

Quantification of cerebral blood flow in nonhuman primates using arterial spin labeling and a two-compartment model

Cited by 21 publications

References 53 publications

Analysis of Cerebral Hemodynamics in Healthy Adult Rhesus with Dynamic Susceptibility Contrast Perfusion (DSC-MR) Imaging

Analysis of Cerebral Hemodynamics in Healthy Adult Rhesus with Dynamic Susceptibility Contrast Perfusion (DSC-MR) Imaging

Arterial spin labelling reveals prolonged arterial arrival time in idiopathic Parkinson's disease

Brain Temperature Measured by Using Proton MR Spectroscopy Predicts Cerebral Hyperperfusion after Carotid Endarterectomy

Contact Info

Product

Resources

About