: Anaplastic thyroid cancer ATC has a poor prognosis because of immediate metastasis. Several studies in humans and animals have suggested that the ingestion of green tea or its active ingredient --epigallocatechin-3-gallate EGCG may decrease the risk of cancer. Using a recently developed real-time cell analysis RTCA system, we have shown previously that EGCG inhibits cell migration and the invasion of oral cavity cancers by suppressing matrix metalloproteinases. In the present study we used RTCA to investigate the effects of EGCG on cell adhesion to bronectin-coated plates using three cancer cell lines : one ATC cell line TCO-1 and two poorly differentiated oral squamous cell carcinomas OSCCs cell lines SAS and HO-1-u-1 ; originating from the tongue and oor of the mouth, respectively . EGCG 50 µM inhibited the adhesion of all three cell lines. In addition to its effects on cell adhesion, 50 µM EGCG inhibited the cell proliferation of TCO-1 cells. Furthermore, EGCG decreased V integrin ITGAV mRNA levels in all three cell lines, suggesting that EGCG inhibits the cell adhesion and proliferation of OSCC and ATC cells via suppression of integrin expression. Therefore, EGCG represents a useful dietary constituent or a lead compound for counteracting metastasis of oral cavity cancers and thyroid cancers.