Quantification of Carotid Plaque Neovascularization Using Contrast-Enhanced Ultrasound With Histopathologic Validation

Li, Chaolun; He, Wenzhuan; Guo, Daqiao; Chen, Lingli; Jin, Xuejuan; Wang, Weiping; Huang, Beijian; Wang, Wenping

doi:10.1016/j.ultrasmedbio.2014.02.010

Cited by 50 publications

(57 citation statements)

References 24 publications

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“…Previous studies have shown that the temporal parameter EI is correlated with the histological MVD, 2,16 and this study confirms the reliability of the correlation. Furthermore, it has been shown that EIR, another temporal parameter that agrees with visual grading on CEUS, 5 is also correlated with MVD (r ¼ .75; Table 1).…”

Section: Discussionsupporting

confidence: 88%

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Spatio-temporal Quantification of Carotid Plaque Neovascularization on Contrast Enhanced Ultrasound: Correlation with Visual Grading and Histopathology

Zhang

Han

et al. 2015

European Journal of Vascular and Endovascular Surgery

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Section: Discussionsupporting

confidence: 88%

“…2,6,16,17 Thus, it is speculated that correlations may also exist between spatial and temporal parameters. Here, correlations between the two types of parameters are reported for the first time.…”

Section: Discussionmentioning

confidence: 99%

Spatio-temporal Quantification of Carotid Plaque Neovascularization on Contrast Enhanced Ultrasound: Correlation with Visual Grading and Histopathology

Zhang

Han

et al. 2015

European Journal of Vascular and Endovascular Surgery

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“…Для оценки степени стенозирования СА в большинстве российских клиник (и нами) используется комплексный подход на основе критериев ECST [17]. Запись видеоролика исследования проводится в формате DICOM, начиная от момента введения препарата на протяжении 120 сек, времени пока контрастный препарат находится в зоне интереса [3,6]. По данным разных авторов время записи видеоклипа колеблется от 90 до 150 сек [7,18].…”

Section: методические аспекты проведения исследованияunclassified

“…Многочисленные исследования продемонстрировали взаимосвязь между степенью накопления контрастного вещества внутри АСБ и выраженностью неоваскуляризации по данным гистологических исследований [3][4][5][6][7], симптомностью АСБ в сонных артериях (СА) [8] и эхогенностью АСБ [9]. Наличие патологических неососудов, неовасуляризации бляшки по данным контрастного ультразвукового исследования отражает воспаление в бля шке, свидетельствуя о ее нестабильности [10,11], и может быть использовано в прогнозировании неблагоприятных сосудисто-мозговых событий и стратификации риска у больных с сердечно-сосудистыми заболеваниями [12,13].…”

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Contrast-enhanced carotid ultrasound: current status

2019

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Unstable atherosclerotic plaques (ASP) are the cause of acute ischemia in the carotid and coronary systems. Numerous studies have shown a relationship between plaque instability, manifestations, echogenicity, histological findings and its neovascularization. The presence and extent of ASP neovascularization in the carotid arteries can be detected for the first time using contrast-enhanced carotid ultrasound. Contrast-enhanced carotid ultrasound does not have nephrotoxic effect; it also improves the accuracy of plaque ulceration detecting and determining the severity of stenosis. The article presents the opinions of the authors and international experts on contrast ultrasound of peripheral arteries. An analysis of the literature data and our own observations is presented. Significant parameters such as the doses, procedure onset time and duration, methods for the qualitative and quantitative assessment of plaque neovascularization are analyzed. The difficulties of contrast-enhanced ultrasound are described.

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“…Importantly, there appears to be a good correlation between ultrasound imaging and subsequent histopathological findings [2,11,18,19]. In particular, ultrasound investigations into intraplaque neovascularization have garnered increasing attention since intraplaque neovascularization holds promise as an indirect marker of the amount of infiltrated inflammatory cells [2,11,19]. …”

Section: Introductionmentioning

confidence: 99%

Identification of neovascularization by contrast–enhanced ultrasound to detect unstable carotid stenosis

et al. 2017

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BackgroundPlaque neovascularization accompanies local inflammation and critically contributes to plaque instability. Correct identification of intraplaque neovascularization by contrast–enhanced ultrasound (CEUS) may provide an additional risk marker in carotid stenosis. This pilot study investigates the correlation between histological evaluation of carotid plaque specimens and pre-surgery CEUS to identify neovascularization.Methods17 patients with high-grade internal carotid artery (ICA) stenosis were studied. CEUS was performed in all patients shortly before carotid endarterectomy. Neovascularization, infiltration of T cells and macrophages along with intraplaque hemorrhage were studied in excised plaques by immunohistochemistry. Ultrasound-based four-level and two-level classification systems for neovascularization were used. CEUS findings were compared with histological findings.ResultsScores on the CEUS-based four-level and two-level classifications were robustly correlated with the density of intraplaque vessels (r = 0.635, p = 0.006 and r = 0.578, p = 0.015, respectively). Histological evaluation of regions with strong and prolonged intraplaque enhancement typically showed strong intraplaque neovascularization in conjunction with acute intraplaque hemorrhage. Moreover, higher grades of intraplaque neovascularization as determined by ultrasound were associated with a higher percentage of macrophage-rich areas.ConclusionCEUS is a technique well suited to gauge the degree of neovascularization of carotid plaques. Future research will have to define the reliability and validity of CEUS in everyday clinical practice. Further, our study suggests that CEUS may also be useful to pick up features of vulnerable plaques such as acute intraplaque hemorrhages.

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Quantification of Carotid Plaque Neovascularization Using Contrast-Enhanced Ultrasound With Histopathologic Validation

Cited by 50 publications

References 24 publications

Spatio-temporal Quantification of Carotid Plaque Neovascularization on Contrast Enhanced Ultrasound: Correlation with Visual Grading and Histopathology

Spatio-temporal Quantification of Carotid Plaque Neovascularization on Contrast Enhanced Ultrasound: Correlation with Visual Grading and Histopathology

Contrast-enhanced carotid ultrasound: current status

Identification of neovascularization by contrast–enhanced ultrasound to detect unstable carotid stenosis

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