2012
DOI: 10.1002/jmri.23943
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Quantification of BOLD fMRI parameters to infer cerebrovascular reactivity of the middle cerebral artery

Abstract: Purpose To quantify the amplitude and temporal aspects of the BOLD response to an auditory stimulus during normocapnia and hypercapnia in healthy subjects in order to establish which BOLD parameters are best suited to infer the cerebrovascular reactivity (CVR) in the middle cerebral artery (MCA) territory. Materials and Methods Twenty healthy volunteers (mean age: 23.6 ± 3.7 years, 11 women) were subjected to a functional paradigm composed of five epochs of auditory stimulus (3 seconds) intercalated by six i… Show more

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Cited by 2 publications
(2 citation statements)
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“…BOLD-fMRI signals provide real-time cerebral oxygen distribution under normal physiological conditions, based on local magnetic field properties resulting from a mismatch between local oxygen consumption caused by neuronal activity and increased CBF reactivity (85). BOLD signal has four parameters: onset time, time to peak, full width at half maximum (FWHM), and amplitude (86). The increase of local CBF causes a reduction in the local amount of deoxygenated hemoglobin generated by metabolism in response to neuronal activity, presenting signal enhancement (T2 and T2*) in related brain regions (100).…”
Section: Blood Oxygenation Level-dependent Functional Mrimentioning
confidence: 99%
“…BOLD-fMRI signals provide real-time cerebral oxygen distribution under normal physiological conditions, based on local magnetic field properties resulting from a mismatch between local oxygen consumption caused by neuronal activity and increased CBF reactivity (85). BOLD signal has four parameters: onset time, time to peak, full width at half maximum (FWHM), and amplitude (86). The increase of local CBF causes a reduction in the local amount of deoxygenated hemoglobin generated by metabolism in response to neuronal activity, presenting signal enhancement (T2 and T2*) in related brain regions (100).…”
Section: Blood Oxygenation Level-dependent Functional Mrimentioning
confidence: 99%
“…• Pode-se obter outros fatores de importância vascular, como por exemplo o tempo do início de resposta, duração e amplitude (MAZZETTO-BETTI et al, 2013).…”
Section: Ressonância Magnética De Marcação Do Sangue Arterialunclassified