Quantification of bleeding during dental extraction in patients on dual antiplatelet therapy

Incidence of bleeding after minor oral surgery in patients on dual antiplatelet therapy: a systematic review and meta-analysis

“…11 , Lillis et al 15 showed a significantly higher frequency of events for DAPT compared to SAPT and no APT. Additionally, Buhatem Medeiros et al 16 showed a significantly higher volume of blood loss in those on DAPT compared to those on no APT. On the other hand, Park et al 17 reported no significant difference in blood loss exceeding 30 ml between the DAPT, SAPT, and no APT groups.…”

“…Nine studies were prospective controlled cohort studies [11][12][15][16][17][18]20,[25][26] , five were retrospective controlled cohort studies [13][14][21][22][23] , and two were prospective case-series studies 19,24 . In total, the studies included 1059 patients on DAPT, 1428 patients on SAPT, 4452 patients not on APT (no APT), and 111 patients on triple antiplatelet therapy (TAPT) or vitamin K antagonists (VKAs).…”

“…Four studies included various minor oral procedures such as dental extraction, alveoloplasty, apical surgery, cyst removal, and periodontal treatment [11][12][13][14] . All other studies included solely dental extractions: 10 included multiple dental extractions [15][16][17][18][19][20][21][22][23][24] and two limited inclusion to the non-surgical extraction of one tooth 25,26 . Exclusion criteria were similar for all studies, i.e., patients with systemic (such as liver or renal) diseases, congenital bleeding disorders, an abnormal blood count, suffering from alcoholism, or taking medication affecting haemostasis (apart from antiplatelet drugs) were excluded.…”

“…In total, 377 articles were identified via the electronic database search and one article in the hand search. After removing duplicates and screening by title and abstract, 18 papers were included for full-text assessment [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] . Two of these were excluded 27,28 and 16 were included for quantitative and qualitative synthesis [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] (Fig.…”

“…In all studies except two, gauze pressure was employed as the primary haemostatic measure, whether or not in combination with sutures (Supplementary Material, After database screening, the hand search of journals and reference lists, and the removal of duplicates, 253 articles were evaluated by title and abstract. Eighteen were included for full-text assessment [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] , of which two were excluded 27,28 . One article included patients who had undergone orthognathic surgery, which is not considered a minor oral surgical intervention 27 .…”