“…The original QuEChERS (an acronym for Quick, Easy, Cheap, Effective, Rugged, Safe) extraction method was developed by Anastassiades et al (2003) for analysis of pesticide residues in plants. Considering its potential advantages, the QuEChERS extraction approach was evaluated in toxicological analysis in the forensic and clinical context and applied to human biological specimens such as urine (Usui, Hayashizaki, Minagawa, et al, 2012), serum (Pouliopoulos et al, 2018), blood (Anzillotti et al, 2014; Dulaurent et al, 2016; Matsuta et al, 2013; Pouliopoulos et al, 2018; Usui, Hayashizaki, Hashiyada, & Funayama, 2012) and liver (Usui et al, 2014). The potential advantages of this extraction method in analytical toxicology include reduction of matrix effects, operational simplicity and high extraction efficiency for many different analytes (Usui, Hayashizaki, Hashiyada, & Funayama, 2012).…”