Quantification of 11 metabolites in rat urine after exposure to organophosphates
Michael A. Leninsky,
Vladislav E. Sobolev,
Margarita O. Sokolova
et al.
Abstract:Background
The aim of the study was to develop a technique for quantitative determination of rat urine metabolites by HPLC–MS/MS, which can be used to search for biomarkers of acute intoxication with organophosphates (OPs).
Results
The content of metabolites in the urine of rats exposed to a single dose of paraoxon (POX1x); interval, twice daily administration of paraoxon (POX2x); exposure to 2-(o-cresyl)-4H-1, 3, 2-benzodioxaphosphorin-2-oxide and… Show more
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