Quantification of 10 elements in human cerebrospinal fluid from chronic pain patients with and without spinal cord stimulation

Objective Measures to Characterize the Physiological Effects of Spinal Cord Stimulation in Neuropathic Pain: A Literature Review

“…These findings provided further evidence of the effects of SCS on the neurochemical environment of the human spinal cord. In another recent study, Korvela et al used inductively coupled plasma mass spectroscopy and inductively coupled plasma atomic emission spectroscopy to quantify ten elements in CSF from SCS patients . They did not detect any significant changes in the element concentrations in CSF from treatment with SCS.…”

“…Twelve studies from our search used proteomic, vascular, and/or pedometric measures to assess the mechanistic effects of SCS (40,41,52,(83)(84)(85)(86)(87)(88)(89)(90)(91) (Table 5). Five of these studies quantified changes in the cerebrospinal fluid (CSF) to identify potential biochemical markers of SCS (40,(85)(86)(87)(88). A study by Tonelli et al used radioimmunoassays to measure CSF concentrations of endogenous opioids in 17 patients with chronic pain, before and after SCS (88).…”

FI-ICP-TOFMS for quantification of biologically essential trace elements in cerebrospinal fluid – high-throughput at low sample volume

“…Previous studies already showed the application of this technique for the elemental quantification in the CSF using different ICP-MS instruments. The most common instrumental ICP-MS setups in this regard make use of sequential quadrupole [7][8][9] or sector-field mass analyzers [10][11][12][13] (ICP-QMS and ICP-SFMS), offering interference control either by collision/reaction cell gas technology or by high mass resolving power. The specificity of reactions in the reaction cell in single quadrupole or tandem quadrupole ICP-MS configurations is especially advantageous for the interference-free determination of single elements, as shown by various examples in the literature.…”

Relationship of some ultra trace elements with atherosclerosis

“…normal physiology and playing important roles in a status of CVDs. 6 Normal values help in the recognition the health state of the population, therapy of disease, 7 and they are important to evaluate the occupational and environmental exposures. 8 Trace elements (TE) are necessary to the body of the human being, they are related to the physiology of the body 9 as well as they are considered as an essential part of enzymes, hormones and vitamins.…”