Quantification by Dual Photonabsorptiometry of Local Bone Loss After Fracture

Fm, Ulivieri; Bossi, E; Azzoni, R.; Ronzani, Carole; Trévisan, C.; Montesano, Angelo; Ortolani, S.

doi:10.1097/00003086-199001000-00038

Cited by 55 publications

(29 citation statements)

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“…The resorption rate m r obtained for the rat tibia was more than two times higher compared to the one obtained for the human tibia (Terrier, 1999). Moreover, the value of s r obtained here for the rats was more then 10 times lower than the one obtained with the same theory from human clinical data on the tibia (Ulivieri et al, 1990). These findings are consistent with previous studies (see review of Cowin, 1989) that lead to the conclusion that adaptation gets faster as mammals become smaller.…”

Section: Discussionsupporting

confidence: 91%

“…Delay of three to four days reflects the time required for communication of mechanical signal to osteoprogenitor cells and their differentiation into active osteoblasts (Turner et al, 1998). Other experimental studies have reported that a period of four to five days is necessary after a mechanical stimulus before bone formation begins (Vico and Alexandre, 1989;Ulivieri et al, 1990;Turner and Forwood, 1994;Turner et al, 1998;Verborgt et al, 2000). During an in vivo experiment of rats, it was observed that a single fourpoint bending (2000 microstrains, 36 cycles at 2 Hz) increased the length of periosteum covered with osteoblasts as early as day 2, with a peak at day 3, and a return to non-loaded levels by day 9 (Boppart et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

“…Following an immobilization of the lower limb after a fracture of the human tibia, the densification process caused by remobilization was only observed several weeks after the remobilization started (Ulivieri et al, 1990). Conversely, rat experiments pointed out that the rate of bone formation increased significantly in weeks 3-5 only after the physical exercise started (Bourrin et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

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Delay of intracortical bone remodelling following a stress change: A theoretical and experimental study

Terrier¹,

Miyagaki²,

Fujie³

et al. 2005

Clinical Biomechanics

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Background. A theoretical model and an experimental setup were specifically designed to identify and determine the delay of the cortical bone response (restricted to mineralization and demineralization) to a stress change.Methods. The in vivo experiment considered two groups of rats: a running group and a control sedentary group. The running group rats were compelled to a running activity for 15 weeks, followed by a sedentary activity for 15 weeks. Bone density was derived from hardness measurements. The parameters of the remodelling theory, including the response delay and the remodelling rates, were determined from these experimental measurements.Findings. Bone density increased significantly during the activity period, and decreased rapidly when rats returned to sedentary state. The identification of the modelÕs parameters produced evolution curves that were within the limits of the standard deviation of the experimental data. The densification rate was lower than the resorption rate, and the densification delay was greater than bone resorption delay.Interpretation. The delays determined with this macroscopic model are related to response delays due to biological internal processes in bone.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Delay of intracortical bone remodelling following a stress change: A theoretical and experimental study

Terrier¹,

Miyagaki²,

Fujie³

et al. 2005

Clinical Biomechanics

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“…Osteotomy procedure was performed on the right tibia in all cases, but both tibiae were used in the ultrasonometric analysis, because of the need to compare operated side to the healthy one. The comparison with the contralateral healthy limb co-validates the methodology because it presents safer and accurate results (8,9,10,11,12) . The shortcoming regarding the use of sheep is the poor availability of those animals, which must be found in slaughterhouses at a relatively high cost by animal, which makes the use of such animals to be expensive and difficult, also due to lodging limitations.…”

Section: Discussionmentioning

confidence: 58%

“…A single value proposed for speed cannot be used as an indicative of the full osseous union. The intact contralateral bone can be used as control, indicating the value of the end-point osseous healing, because some authors demonstrated that significant changes do not occur on a contralateral, non-fractured bone density, from the moment of the fracture until the complete healing of the fractured bone (10,11,12) .…”

Section: * Soundscan 2000mentioning

confidence: 99%

Avaliação ultra-sonométrica da consolidação de osteotomias mediodiafisárias transversas em diferentes períodos: estudo experimental em tíbias de carneiro

Barbieri

Matos

et al. 2005

Acta ortop. bras.

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Foi realizado um estudo experimental sobre a avaliação ultra-sonométrica da consolidação de tíbias de carneiros submetidas a osteotomia transversal mediodiafisária, utilizando 15 carneiros, com pêso médio de 37 Kg, divididos em três grupos experimentais de cinco animais cada, conforme o período de observação pós-operatória de 30, 45 e 60 dias. As osteotomias foram realizadas nas tíbias direitas dos animais, ficando as tíbias esquerdas como controle. Foi feita avaliação radiográfica da consolidação a cada duas semanas e, ao fim do período de observação, os animais foram sacrificados e as tíbias, removidas para a análise ultra-sonométrica. Foram medidos e correlacionados o diâmetro da tíbia e a velocidade de propagação transversal do ultra-som na região da osteotomia, em duas direções diferentes (perpendicular e paralela ao plano da tuberosidade anterior da tíbia). A velocidade de propagação do ultra-som aumentou com o avançar da consolidação (±5%), sendo as diferenças significantes em relação ao grupo-controle, mas não entre os grupo experimentais. Os diâmetros diminuíram nas duas direções medidas, sendo as diferenças significantes entre os grupos, com forte correlação negativa com a velocidade. Concluiu-se que o método de avaliação da consolidação pela ultra-sonometria é factível, com resultados confiáveis e precisos.

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Osteoporosis. Frequency, consequences, and risk factors

Ross¹

1996

Archives of Internal Medicine

147

103

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More than half of all women and about one third of men will experience osteoporotic fractures during their lives. Although no symptoms occur prior to fracture, bone mineral density and other risk factors can be used to identify high-risk patients, and because effective interventions exist, many of these fractures are now preventable. The proportion of people who are affected, the mortality and morbidity resulting from osteoporotic fractures, and the major known risk factors are discussed. Greater attention should be given to measuring bone mineral density and identifying other risk factors to quantitate the degree of fracture risk among patients (with or without a history of previous fractures), because the consequences of fractures often are severe, and no symptoms other than fractures are associated with disease progression.

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Quantification by Dual Photonabsorptiometry of Local Bone Loss After Fracture

Cited by 55 publications

References 0 publications

Delay of intracortical bone remodelling following a stress change: A theoretical and experimental study

Delay of intracortical bone remodelling following a stress change: A theoretical and experimental study

Avaliação ultra-sonométrica da consolidação de osteotomias mediodiafisárias transversas em diferentes períodos: estudo experimental em tíbias de carneiro

Osteoporosis. Frequency, consequences, and risk factors

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