Quantification and reproducibility assessment of the regional brain <i>T</i><sub>2</sub> relaxation in naïve rats at 7T

Liachenko, Serguei; Ramu, Jaivijay

doi:10.1002/jmri.25378

Cited by 17 publications

(15 citation statements)

References 42 publications

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“…Altogether, reported values are in good agreement with several recent studies (Del Bigio et al, 2011, Gigliucci et al, 2014, Koundal et al, 2015, Liachenko and Ramu, 2017, Suleymanova et al, 2014. In conclusion, we have demonstrated the feasibility of multicenter preclinical studies, sharing raw data and processing pipelines between distributed centers.…”

Section: Discussionsupporting

confidence: 91%

“…They show that T1 relaxation time increases with magnetic field while T2 relaxation time decreases (de Graaf et al, 2006, Wright et al, 2008, van de Ven et al, 2007. Some values have been reported in the literature for few brain regions (Barbier et al, 2005, Behroozi et al, 2018, Cremillieux et al, 1998, Del Bigio et al, 2011, Gigliucci et al, 2014, Koundal et al, 2015, Liachenko and Ramu, 2017, Suleymanova et al, 2014, but no consensus has been reached yet about values of reference for specific rat brain regions. To define such reference maps, a large number of brain structures or regions should be considered and a sufficient number of animals should be included to reflect inter-individual variability.…”

Section: Discussionmentioning

confidence: 99%

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A Multicenter Preclinical MRI Study: Definition of Rat Brain Relaxometry Reference Maps

Deruelle¹,

Kober

Perles-Barbacaru

et al. 2020

Preprint

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Similarly to human population imaging, there are several well-founded motivations for animal population imaging, the most notable being the improvement of the validity of statistical results by pooling a sufficient number of animal data provided by different imaging centers. In this paper, we demonstrate the feasibility of such a multicenter animal study, sharing raw data from forty rats and processing pipelines between four imaging centers. As specific use case, we considered the estimation of T1 and T2 maps for the healthy rat brain at 7T. We quantitatively report about the variability observed across two data provider centers and evaluate the influence of image processing steps on the final maps, by using three fitting algorithms from three centers.Finally, to derive relaxation time values per brain area, two multi-atlas segmentation pipelines from different centers were executed on two different platforms. In this study, the impact of the acquisition was 2.21% (not significant) and 9.52% on T1 and T2 estimates while the impact of the data processing pipeline was not significant (1.04% and 3.33%, respectively). In addition, the computed normality values can serve as relaxometry reference maps to explore differences to animal models of pathologies.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

A Multicenter Preclinical MRI Study: Definition of Rat Brain Relaxometry Reference Maps

Deruelle¹,

Kober

Perles-Barbacaru

et al. 2020

Preprint

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“…In the present 7T study, we have used a CPMG sequence with 10.73‐ms interpulse interval. Studies in humans and animals have reported that T 2 values measured in brain tissue using CPMG sequences are dependent on the refocusing interval due to dynamic dephasing caused by the strong magnetic field gradients created by deoxygenated blood in veins and eventual iron/ferritin deposits. Therefore, it is important to keep in mind that the T 2 values reported in the present study correspond to the so‐called apparent T 2 , as defined in .…”

Section: Discussionmentioning

confidence: 99%

In vivo measurement of T₁ and T₂ relaxation times in awake pigeon and rat brains at 7T

Behroozi

Chwiesko

Ströckens

et al. 2017

Magnetic Resonance in Med

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The obtained T and T values for awake pigeons and rats and the optimized habituation protocol will augment future MRI studies with awake animals. The differences in relaxation times observed between species underline the importance of the acquisition of T /T values as reference points for specific experiments. Magn Reson Med 79:1090-1100, 2018. © 2017 International Society for Magnetic Resonance in Medicine.

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“…They show that T1 relaxation time increases with magnetic field while T2 relaxation time decreases (de Graaf et al, 2006;van de Ven et al, 2007;Wright et al, 2008). Some studies also reported regional values (Cremillieux et al, 1998;Barbier et al, 2005;Del Bigio et al, 2011;Gigliucci et al, 2014;Suleymanova et al, 2014;Koundal et al, 2015;Liachenko and Ramu, 2017;Behroozi et al, 2018), but no consensus has been reached yet about values of reference for specific rat brain regions. To define such reference maps, a large number of brain structures or regions should be considered and a sufficient number of animals should be included to reflect inter-individual variability.…”

Section: Introductionmentioning

confidence: 99%

A Multicenter Preclinical MRI Study: Definition of Rat Brain Relaxometry Reference Maps

Deruelle

Kober

Perles-Barbacaru

et al. 2020

Front. Neuroinform.

View full text Add to dashboard Cite

Similarly to human population imaging, there are several well-founded motivations for animal population imaging, the most notable being the improvement of the validity of statistical results by pooling a sufficient number of animal data provided by different imaging centers. In this paper, we demonstrate the feasibility of such a multicenter animal study, sharing raw data from forty rats and processing pipelines between four imaging centers. As specific use case, we focused on T1 and T2 mapping of the healthy rat brain at 7T. We quantitatively report about the variability observed across two MR data providers and evaluate the influence of image processing steps on the final maps, using three fitting algorithms from three centers. Finally, to derive relaxation times from different brain areas, two multi-atlas segmentation pipelines from different centers were performed on two different platforms. Differences between the two data providers were 2.21% for T1 and 9.52% for T2. Differences between processing pipelines were 1.04% for T1 and 3.33% for T2. These maps, obtained in healthy conditions, may be used in the future as reference when exploring alterations in animal models of pathology.

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Quantification and reproducibility assessment of the regional brain T₂ relaxation in naïve rats at 7T

Abstract: 1 J. Magn. Reson. Imaging 2017;45:700-709.

Cited by 17 publications

References 42 publications

A Multicenter Preclinical MRI Study: Definition of Rat Brain Relaxometry Reference Maps

A Multicenter Preclinical MRI Study: Definition of Rat Brain Relaxometry Reference Maps

In vivo measurement of T₁ and T₂ relaxation times in awake pigeon and rat brains at 7T

A Multicenter Preclinical MRI Study: Definition of Rat Brain Relaxometry Reference Maps

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Quantification and reproducibility assessment of the regional brain T2 relaxation in naïve rats at 7T

Abstract: 1 J. Magn. Reson. Imaging 2017;45:700-709.

Cited by 17 publications

References 42 publications

A Multicenter Preclinical MRI Study: Definition of Rat Brain Relaxometry Reference Maps

A Multicenter Preclinical MRI Study: Definition of Rat Brain Relaxometry Reference Maps

In vivo measurement of T1 and T2 relaxation times in awake pigeon and rat brains at 7T

A Multicenter Preclinical MRI Study: Definition of Rat Brain Relaxometry Reference Maps

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Product

Resources

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Quantification and reproducibility assessment of the regional brain T₂ relaxation in naïve rats at 7T

In vivo measurement of T₁ and T₂ relaxation times in awake pigeon and rat brains at 7T