Quantification and localization of kainic acid-induced neurotoxicity employing a new biomarker of cell death: cleaved microtubule-associated protein-tau (c-tau)

Zemlan, Frank P.; Mulchahey, J.J.; Gudelsky, Gary A.

doi:10.1016/s0306-4522(03)00459-7

Cited by 23 publications

(18 citation statements)

References 30 publications

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“…After various types of brain damage such as traumatic brain injury (TBI), there is a rapid loss of intracellular MAP tau which is then proteolytically cleaved at both C-and N-terminals to form cleaved tau (C-tau) proteins that are then transported by convective bulk flow to the CSF [9]. C-tau is an established biomarker of neuronal damage in TBI, subarachnoid hemorrhage, Alzheimer's disease, and in childhood hydrocephalus [9][10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Increased cerebrospinal fluid cleaved tau protein (C-tau) levels suggest axonal damage in pediatric patients with brain tumors

Cengiz

Zemlan

Eickhoff³

et al. 2015

Childs Nerv Syst

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Cerebrospinal fluid cleaved tau levels in children with newly diagnosed brain tumors exhibit markedly elevated cerebrospinal fluid cleaved tau levels, suggesting axonal damage. This axonal injury does not seem to correlate with lipid peroxidation at least when as assessed by cerebrospinal fluid 9-hydroxyoctadecadienoic acid levels. There was no association found between the biomarkers and multiple independent variables obtained at pre- and post-tumor resection.

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Section: Introductionmentioning

confidence: 99%

Increased cerebrospinal fluid cleaved tau protein (C-tau) levels suggest axonal damage in pediatric patients with brain tumors

Cengiz

Zemlan

Eickhoff³

et al. 2015

Childs Nerv Syst

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“…Those Tau fragments were shown to be present in the brain tissue [84]. A 14-kDa fragment of Tau was also evidenced by Zemlan and collaborators using C-terminal Tau antibodies [173]. More recently, a characterization by mass spectrometry of Tau in human CSF identified 19 tryptic fragments, of which 16 are common to all isoforms and three specific to unique Tau isoforms [174].…”

Section: Csf-ttau and Ptau As Therapeutic Monitoring Biomarkersmentioning

confidence: 77%

Tau as a Biomarker of Neurodegenerative Diseases

et al. 2008

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The microtubule-associated protein Tau is mainly expressed in neurons of the CNS and is crucial in axonal maintenance and axonal transport. The rationale for Tau as a biomarker of neurodegenerative diseases is that it is a major component of abnormal intraneuronal aggregates observed in numerous tauopathies, including Alzheimer's disease. The molecular diversity of Tau is very useful when analyzing it in the brain or in the peripheral fluids. Immunohistochemical and biochemical characterization of Tau aggregates in the brain allows the postmortem classification and differential diagnosis of tauopathies. As peripheral biomarkers of Alzheimer's disease in the cerebrospinal fluid, Tau proteins are now validated for diagnosis and predictive purposes. For the future, the detailed characterization of Tau in the brain and in peripheral fluids will lead to novel promising biomarkers for differential diagnosis of dementia and monitoring of therapeutics.

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“…Some research studies reported that cleaved t (c-t) could be detected in the CSF and serum of TBI patients [18][19][20]. C-t could reflect the severity of TBI [18] and predict intracranial lesions [20].…”

Section: Figmentioning

confidence: 99%

“…C-t could reflect the severity of TBI [18] and predict intracranial lesions [20]. C-t, reported by Zemlan and colleagues [18][19][20], is a truncated t protein (30 to 50 Kd) that is shorter than the full-length t protein (48 to 68 Kd) and lacks the N-and C-terminal domains. Because of different measurement methods, the relation between the t proteins detected by our methods [8][9][10][11] and c-tby other groups [18][19][20][21] cannot be determined at present.…”

Section: Figmentioning

confidence: 99%