Quantification analysis of lactate dehydrogenase and C-reactive protein in evaluation of the severity and prognosis of the acute pancreatitis

Yin, Xinhua; Xu, Jing; Zhang, Qi; Li, Yang; Duan, Yunjie

doi:10.14715/cmb/2019.66.1.20

Cited by 9 publications

(8 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, in this study, we didn’t find any difference in HDL level between the POF and the TOF groups, which could be due to the different etiological characteristics of AP in the general population and APIP. The etiology of AP in the general population is mainly biliary type ( 34 , 35 ), while APIP is mainly HTG type ( 1 ). The changes of lipid metabolism in the latter may be different from that in biliary type AP.…”

Section: Discussionmentioning

confidence: 99%

Nomogram for Predicting Persistent Organ Failure With Acute Pancreatitis in Pregnancy

Sheng

Wang

2022

Front. Endocrinol.

View full text Add to dashboard Cite

BackgroundAcute pancreatitis in pregnancy (APIP) with persistent organ failure (POF) poses a high risk of death for mother and fetus. This study sought to create a nomogram model for early prediction of POF with APIP patients.MethodsWe conducted a cross-sectional study on APIP patients with organ failure (OF) between January 2012 and March 2021. 131 patients were collected. Their clinical courses and pregnancy outcomes were obtained. Risk factors for POF were identified by univariate and multivariate logistic regression analysis. Prediction models with POF were built and nomogram was plotted. The performance of the nomogram was evaluated by using a bootstrapped-concordance index and calibration plots.ResultsHypertriglyceridemia was the most common etiology in this group of APIP patients, which accounted for 50% of transient organ failure (TOF) and 72.3% of POF. All in-hospital maternal death was in the POF group (P<0.05), which also had a significantly higher perinatal mortality rate than the TOF group (P<0.05). Univariate and multivariate logistic regression analysis determined that lactate dehydrogenase, triglycerides, serum creatinine, and procalcitonin were independent risk factors for predicting POF in APIP. A nomogram for POF was created by using the four indicators. The area under the curve was 0.875 (95%CI: 0.80–0.95). The nomogram had a bootstrapped-concordance index of 0.85 and was well-calibrated.ConclusionsHypertriglyceridemia was the leading cause of organ failure-related APIP. Lactate dehydrogenase, triglycerides, serum creatinine, and procalcitonin were the independent risk factors of POF in APIP. Our nomogram model showed an effective prediction of POF with the four indicators in APIP patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Nomogram for Predicting Persistent Organ Failure With Acute Pancreatitis in Pregnancy

Sheng

Wang

2022

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

“…Therefore, we speculate that LDH may play a role in predicting adverse events. To patients with tumor, such as small cell lung cancer, hepatocellular carcinoma, and acute pancreatitis, elevated LDH represents a bad prognosis [ 15 , 20 , 21 ]. These discoveries confirmed our speculation.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of a Novel Parameter in Patients with Infective Endocarditis

Chen

Liu

Qiao

et al. 2022

BioMed Research International

View full text Add to dashboard Cite

Background. Infective endocarditis (IE) has a high rate of mortality and the prognosis of IE was poor. The purpose of this investigation was to explore the value of lactate dehydrogenase (LDH)/lymphocyte and compare it with LDH/lymphocyte percentage (L-LWR) in predicting the in-hospital mortality in IE patients. Methods. The investigation cohort contained 147 IE patients between January 2017 and December 2019. We retrospectively went over the medical records and selected admission indexes. Results. Compared with IE patients with adverse events, significantly higher levels of LDH/lymphocyte and significantly lower levels of L-LWR were discovered in IE patients without adverse events. After adjustments, L-LWR (odds ratio (OR): 4.558, 95% confidence interval (CI) 1.362-15.256, P = 0.014 ) still maintained its significant independence. In addition, L-LWR had the highest area under curve (AUC) (0.780, 0.704-0.844, P < 0.001 ) with good sensitivity (81.89%) and specificity (65.00%) when 34 was selected as the best cutoff value. Conclusions. L-LWR is a reliable, low-priced, easily applicable, and independent prognostic parameter for in-hospital death with good performance in patients with IE.

show abstract

“…Procalcitonin is the precursor of the hormone calcitonin found in the thyroid C cells and the pulmonary endocrine cells [26]. However, all tissues have the potential to produce procalcitonin [27].During systemic infections, blood PCT levels rapidly increase within 3-6 h, persisting during the in ammatory process, and decrease as the infection starts to subside [28].Reza has reported that serum PCT was a valuable predictor of SAP in the general population [29].Hence, PCT may facilitate the monitoring of progression in AP in general people [29][30][31].…”

Section: Discussionmentioning

confidence: 99%

Nomogram for Predicting Persistent Organ Failure with Acute Pancreatitis in Pregnancy

Sheng

Wang

2022

Preprint

View full text Add to dashboard Cite

Background: Acute pancreatitis in pregnancy (APIP) with persistent organ failure (POF) poses a high risk of death for mother and fetus. This study sought to create a nomogram model for early prediction of POF with APIP patients.Methods: We conducted a cross-sectional study on APIP patients with organ failure (OF) between January 2012 and March 2021 in a university hospital. 131 patients were collected. Their clinical courses and pregnancy outcomes were obtained. Risk factors for POF were identified by univariate and multivariate logistic regression analysis. Prediction models with POF were built and nomogram was plotted. The performance of the nomogram was evaluated by using a bootstrapped-concordance index and calibration plots.Results: Hypertriglyceridemia was the most common etiology in this group of APIP patients, which accounted for 50% of transient organ failure (TOF) and 72.3% of POF. All in-hospital maternal death was in the POF group (P<0.05), which also had a significantly higher perinatal mortality rate than the TOF group (P<0.05). Univariate and multivariate logistic regression analysis determined that lactate dehydrogenase, triglycerides, serum creatinine, and procalcitonin were independent risk factors for predicting POF in APIP. A nomogram for POF was created by using the four indicators. The area under the curve was 0.875 (95% confidence interval 0.80–0.95). The nomogram had a bootstrapped-concordance index of 0.85 and was well-calibrated.Conclusions: Hypertriglyceridemia was the leading cause of organ failure-related APIP. Lactate dehydrogenase, triglycerides, serum creatinine, and procalcitonin were the independent risk factors of POF in APIP. Our nomogram model showed an effective prediction of POF with the four indicators in APIP patients.

show abstract

Quantification analysis of lactate dehydrogenase and C-reactive protein in evaluation of the severity and prognosis of the acute pancreatitis

Cited by 9 publications

References 14 publications

Nomogram for Predicting Persistent Organ Failure With Acute Pancreatitis in Pregnancy

Nomogram for Predicting Persistent Organ Failure With Acute Pancreatitis in Pregnancy

Prognostic Value of a Novel Parameter in Patients with Infective Endocarditis

Nomogram for Predicting Persistent Organ Failure with Acute Pancreatitis in Pregnancy

Contact Info

Product

Resources

About