QuantiFERON®-TB Gold test in the identification of latent tuberculosis infection in immigrants

Carvalho, Anna Cristina Calçada; Pezzoli, Maria Chiara; El-Hamad, Issa; Arce, Patricia; Bigoni, Sara; Scarcella, Carmelo; Indelicato, A.; Scolari, Carla; Carosi, Giampiero; Matteelli, Alberto

doi:10.1016/j.jinf.2007.02.004

Cited by 38 publications

(31 citation statements)

References 18 publications

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Section: Resultsmentioning

confidence: 99%

“…Across the 51 studies, 34 studies looked at TST alone and 9 studies looked at IGRAs alone [57][58][59][60][61][62][63][64][65]; 8 studies compared TST and IGRAs [66][67][68][69][70][71][72][73]. Just 8 studies excluded those with active TB from their study [23,32,34,50,66,68,69,71]. Only 16 studies reported on BCG vaccination with 9 using BCG scar as evidence of vaccination [28,32,33,53,55,58,60,71,72], 5 using BCG self-reporting as evidence [23,29,35,66,69], and 2 using BCG vaccination schedule in country of origin as a proxy for BCG vaccination [48,73], although BCG vaccination rates varied considerably across studies (0-100 %).…”

Section: Resultsmentioning

confidence: 99%

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A Systematic Review on TST and IGRA Tests Used for Diagnosis of LTBI in Immigrants

et al. 2015

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Prevalence of positive test results were significantly lower in immigrants who were tested with an IGRA, resulting in fewer immigrants being recommended for LTBI treatment compared to TST. Coupled with comparable performance for detecting prevalent TB cases, the IGRA appears to exhibit better specificity than the TST and may be preferred as the standard of care for detecting LTBI in immigrants moving to low TB incidence countries.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

A Systematic Review on TST and IGRA Tests Used for Diagnosis of LTBI in Immigrants

et al. 2015

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“…Recent immigrants from developing countries (\2 years since immigration) are at very high risk of active TB disease due to reactivation of latent infections acquired in the country of origin; for irregular immigrants, additional TB risks are related to social, economic and health care system access problems [29]. In countries with an incidence of active TB less than 10/100,000 habitants, active screening strategies for the identification of these high risk patients are cost effective in view of the control of TB epidemic [30].…”

Section: Introductionmentioning

confidence: 99%

Interferon-γ releasing assay versus tuberculin skin testing for latent tuberculosis infection in targeted screening programs for high risk immigrants

et al. 2010

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The drawback of the TST screening strategy in recent immigrants from highly endemic countries is due to low sensitivity/specificity of the test and to high drop-out rate with an overall significant lowering in strategy efficacy/efficiency. The higher QFT-IT specificity prevents unnecessary overload of the health care system and, although more expensive, might represent a cost-effective alternative to TST in targeted screening programs directed to high risk populations.

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“…The QuantiFERON-TB Gold In-Tube test (QFT-GIT) assay (Cellestis, Carniege, Victoria, Australia) measures the IFN-γ concentration in whole blood after stimulation by specific tuberculosis antigens (e.g., early secreted antigenic target-6 [ESAT-6], culture filtrate protein-10 [CFP-10]), and TB7.7 antigen [8,9]. The QFT-GIT has already been recognized as an efficient alternative test to detect the presence of LTBI [8][9][10][11]; however, whether the QFT-GIT will be useful in monitoring the responses to anti-tuberculosis treatment is unclear [9,12]. The potential prognostic use of IFN-γ responses has been studied in research describing isoniazid (INH) treatment of LTBI and in anti-tuberculosis treatment.…”

Section: Introductionmentioning

confidence: 99%

Use of the QuantiFERON-TB Gold In-Tube Test in the Diagnosis and Monitoring of Treatment Efficacy in Active Pulmonary Tuberculosis

Chang

Wang

Chen

2017

Preprint

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The value of QuantiFERON in the diagnosis of tuberculosis and in the monitoring of the response to anti-tuberculosis treatment is unclear. The aims of this study were to evaluate the accuracy of the QuantiFERON-TB Gold In-Tube (QFT-GIT) test in the diagnosis of tuberculosis and in the monitoring of the response to anti-tuberculosis treatment in patients with active pulmonary tuberculosis (PTB). Between January 2013 and December 2015, 128 cases with active PTB and 128 controls with no mycobacterial infection, matched by age (within 3 years) and by the week that they visited Tainan Chest Hospital, were enrolled in the study. Serial testing by QFT-GIT at baseline and after 2 and 6 months of treatment was performed. At these time points, a comparison of the performance of QFT-GIT with that of sputum culture status among study subjects was conducted. Compared to baseline, 116 (87.2%) cases showed a decreased response, whereas 17 (12.8%) showed persistent or stronger interferon-gamma (IFN-γ) responses at 2 months. Their IFN-γ responses declined significantly from baseline to 2 months (median, 6.32 vs. 4.12; P < 0.005). The sensitivity values of the QFT-GIT test for the detection of pulmonary tuberculosis at cut-off points of 0.35 IU/ml, 0.20 IU/ml, and 0.10 IU/ml were 74.4%, 78.2%, and 80.5%, respectively. The specificity values at cut-off points of 0.35 IU/ml, 0.20 IU/ml, and 0.10 IU/ml were 66.2%, 63.9%, and 57.1%, respectively. Our results support the QFT-GIT assay as a potential tool for diagnosing tuberculosis and for monitoring the efficacy of anti-tuberculosis treatment.

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QuantiFERON®-TB Gold test in the identification of latent tuberculosis infection in immigrants

Cited by 38 publications

References 18 publications

A Systematic Review on TST and IGRA Tests Used for Diagnosis of LTBI in Immigrants

A Systematic Review on TST and IGRA Tests Used for Diagnosis of LTBI in Immigrants

Interferon-γ releasing assay versus tuberculin skin testing for latent tuberculosis infection in targeted screening programs for high risk immigrants

Use of the QuantiFERON-TB Gold In-Tube Test in the Diagnosis and Monitoring of Treatment Efficacy in Active Pulmonary Tuberculosis

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