Quantal Response Analysis

Ashford, J. R.

doi:10.1002/0471667196.ess2123

Cited by 1 publication

(2 citation statements)

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“…From a statistical point of view, the shape of a dose-response curve at very low dose and very high dose, i.e. the tails of the response distribution, are subject to significant measurement error (Ashford, 1985;Morgan, 1992). A large uncertainty, or a lack of statistical power, always remains for any measure of biological response at low dose level.…”

Section: Discussionmentioning

confidence: 99%

“…The proportion of subjects who respond at each dose level represents the cumulative distribution function of the probability of the response to radiation. We used the median effective dose (MED) as a measure to characterize this distribution, because the point estimator of the MED is not subject to measurement errors and is more reliable than the response at either tail of the distribution (Ashford, 1985;Morgan, 1992;Armitage and Colton, 1998). The MED is equivalent to ED 50a (the effective dose 50a), the dose that causes a measurable response in 0.5a probability (i.e.…”

Section: Mathematical Analysismentioning

confidence: 99%

See 1 more Smart Citation

A quantitative model for the evaluation of dose rates effects following exposure to low-dose gamma-radiation

Ogata

Furukawa²,

Kawakami³

et al. 2005

Radioprotection

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Simultaneous consideration of the irradiation time and the cumulative dose isnecessary for evaluating the risk of long-term exposure to radiation at low dose. This study intends to examine several numerical relationships between doses and dose rates in biological responses to gamma radiation. Data on inhibition of [ 3 H] thymidine uptake and micronucleus formation in human osteosarcoma cells were analyzed using the median effective dose (MED) as a measure of the risk. MEDs were calculated using parameters estimated by fitting general logistic curves to the dose-response relationships for each group defined by irradiation time. Both biological responses, the inhibition of [ 3 H] thymidine uptake and micronucleus formation, decreased sharply when the dose rates were less than 0.01 Gy/h. Exponential functions were fitted to the log relationships between MEDs and dose rates. This modified exponential model described well the quantitative effect of dose rates on MEDs, and suggested that risk is extremely low at very low dose rates.

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Section: Discussionmentioning

confidence: 99%

Section: Mathematical Analysismentioning

confidence: 99%