Quantal analysis of potentiating action of phorbol ester on synaptic transmission in the hippocampus

Yamamoto, Chosaburo; Higashima, Masato; Sawada, Satsuki

doi:10.1016/0168-0102(87)90021-6

Cited by 71 publications

(29 citation statements)

References 20 publications

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“…in TTX solution). This eifet was without detectable change in the kinetic properties or amplitudes of the sEPSCs, indicating a presynaptic site of action of 4P-PMA [3,4,16].…”

Section: Resultsmentioning

confidence: 99%

“…The phorbol ester 4p-PMA produced a long-lasting increase in sEPSC frequency, most likely through activation of PKC [1,[3][4][5]. A previous study showed that this effect requires an influx of Ca 2+ through voltage-gated Ca 2+ channels [16].…”

Section: Discussionmentioning

confidence: 99%

“…Thick-wall glass pipettes (1.5-3.5 M£2) were filled with a solution containing (in mM): Cs-gluconate or CsF, 135; MgCl 2 , 2; EGTA, 10; HEPES, 10; Na 2 ATP, [2][3][4][5]GTP,0.2 (pH 7.2). Throughout this study the cells were voltage-clamped at -50 mV and the sEPSCs were filtered at 1-2 kHz and sampled on-line at 10 kHz on the hard disk of a microcomputer driven by the CED software (version 6.0, Cambridge Electronics, UK) [14].…”

Section: Electrophysiologymentioning

confidence: 99%

“…However, the sEPSC (or sIPSC) frequency can be modulated by different protein kinase (PK) activators. For instance, forskolin and phorbol esters, known as cAMP-dependent PKA and PKC activators, respectively, produce a long-lasting modulation of spontaneous transmitter release [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Colchicine affects protein kinase C‐induced modulation of synaptic transmission in cultured hippocampal pyramidal cells

Bouron

1997

FEBS Letters

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“…in TTX solution). This eifet was without detectable change in the kinetic properties or amplitudes of the sEPSCs, indicating a presynaptic site of action of 4P-PMA [3,4,16].…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Electrophysiologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Colchicine affects protein kinase C‐induced modulation of synaptic transmission in cultured hippocampal pyramidal cells

Bouron

1997

FEBS Letters

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“…Considerable interest has consequently been focused on understanding the functional relationship between PKC activation and synaptic plasticity in the hippocampal MF pathway. It has been demonstrated that the activation of PKC by phorbol esters effectively increases the quanta of transmitter released from MF terminals (Yamamoto et al, 1987). In addition, the nootropic (cognitive enhancing) drug bifemaline has been shown to increase the magnitude of MF LTP (Satoh et al, 1988), stimulate the translocation of cytosolic PKC to membranes in the region of the MF synapse (Fujii et al, 1990), and enhance the release of endogenous glutamate from isolated MF nerve endings (Kuraishi et al, 1991).…”

Section: 5mentioning

confidence: 99%

Presynaptic Modulation of the Hippocampal Mossy Fiber Synapse

Terrian¹

1991

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Quantal components of the synaptic potential induced in hippocampal neurons by activation of granule cells, and the effect of 2‐amino‐4‐phosphonobutyric acid

et al. 1991

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The probabilistic nature of excitatory postsynaptic potentials (EPSPs) induced monosynaptically in CA3 neurons by impulses of granule cells was studied in thin transverse sections of the guinea pig hippocampus. More than 600 EPSPs were recorded under several conditions, their amplitudes were measured, and histograms representing the EPSP amplitude distribution were constructed. Quantal parameters were estimated by the method of maximum likelihood. Of 9 neurons examined in the control solution, one neuron showed an exceptionally large number of transmission failures. The amplitude distribution of EPSPs recorded from this neuron could be described by Pascal statistics, but not by binomial or Poisson statistics. The EPSP amplitude distribution from the other neurons could be described by either binomial, Poisson, or Pascal predictions with a minor preference for the last statistic. When an apparently homogeneous group of data was divided into two subgroups and parameters were estimated separately, inconsistent values were obtained in some neurons with no failures. 2-Amino-4-phosphonobutyric acid (APB) suppressed the EPSPs reversibly at relatively low concentrations. Theoretical curves calculated according to the Pascal statistics fit quite well to the entire amplitude distribution of EPSPs recorded under the action of APB. The suppression of EPSPs by APB was accompanied by a marked decrease in mean quantal content (m) with no significant reduction in mean quantal amplitude (q). A quantum induced an increase in membrane conductance of about 150 pS. These results suggest that the release probability of the mossy fiber terminal fluctuates temporally according to a gamma distribution, and that APB reduces the liberation of the transmitter from mossy fiber terminals, thereby suppressing transmission between mossy fibers and CA3 neurons.

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Quantal analysis of potentiating action of phorbol ester on synaptic transmission in the hippocampus

Cited by 71 publications

References 20 publications

Colchicine affects protein kinase C‐induced modulation of synaptic transmission in cultured hippocampal pyramidal cells

Colchicine affects protein kinase C‐induced modulation of synaptic transmission in cultured hippocampal pyramidal cells

Presynaptic Modulation of the Hippocampal Mossy Fiber Synapse

Quantal components of the synaptic potential induced in hippocampal neurons by activation of granule cells, and the effect of 2‐amino‐4‐phosphonobutyric acid

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