Quality of Surgery and Outcome in Extra-Abdominal Aggressive Fibromatosis: A Series of Patients Surgically Treated at a Single Institution

Gronchi, Alessandro; Casali, Paolo G.; Mariani, Luigi; Vullo, Salvatore Lo; Colecchia, Maurizio; Lozza, Laura; Bertulli, Rossella; Fiore, Marco; Olmi, Patrizia; Santinami, Mario; Rosaí, Juan

doi:10.1200/jco.2003.05.150

Cited by 326 publications

(236 citation statements)

References 37 publications

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“…For incomplete resected tumours, the recurrence rate decreases from 39 to 25% after adjuvant radiotherapy, as was presented in a review by NUYTTENS et al [16]. Adjuvant radiotherapy was not a predictor for disease-free survival in other studies [4,15]. Moreover, radiation-related complications, such as radiation pneumonitis, soft tissue necrosis and/ or fibrosis, secondary malignancies and skin problems are well known.…”

Section: Discussionmentioning

confidence: 94%

“…For patients deemed inoperable, primary radiotherapy treatment is a curative option. In two recent large series, no difference was observed in disease-free survival between microscopically positive and negative resection margins after primary resection [4,15]. However, some older and smaller studies showed a small decrease in disease-free survival time for microscopically positive margins as compared with disease-free resection margins [16].…”

Section: Discussionmentioning

confidence: 99%

“…Despite complete resection, the rate of local recurrence is ,30% [16]. Most local recurrences develop within 2 yrs after resection, but a time to recurrence of .10 yrs has also been described [15].…”

Section: Discussionmentioning

confidence: 99%

“…In cases with incomplete resection the radiation dose should be o50 Gray to decrease the risk of local recurrence [17]. The disease-free survival for patients with recurrent disease is less than that for primary desmoid tumours [15].…”

Section: Discussionmentioning

confidence: 99%

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A 20-year-old male with thoracic pain and a lower thoracic mass

Jong

Graaf²,

Jagt³

et al. 2005

European Respiratory Journal

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A 20-yr-old Caucasian male construction worker had a previous history of a road traffic accident 3 yrs before presentation. A computed tomography (CT) scan of the thoracic spine was carried out to exclude vertebral damage. No evidence of vertebral bone damage or other lesions was seen, and the patient recovered without sequelae.A week before presentation, he noticed a stabbing pain in his right hemithorax, without dyspnoea. The pain persisted, and the patient was referred, by his general practitioner, for a chest radiograph ( fig. 1). Based on these results, the patient was referred to a general hospital for further diagnostic tests. A CT scan of thorax and abdomen (not shown) revealed a large mass, which was interpreted to arise in the right upper abdomen, probably originating from the liver. A malignant tumour, or a metastatic lesion, was suspected and the patient was referred to University Medical Center Groningen (Groningen, The Netherlands).The patient did not suffer from dyspnoea, cough or haemoptysis and there was no history of fever, weight loss, fatigue or excessive sweating. There were no neurological or gastrointestinal complaints. The patient was a nonsmoker, and did not use any medication.On physical examination, a healthy appearing, haemodynamically stable young male, of normal posture was seen. On percussion, a dull sound was found in the right lower zone of the chest. Auscultation revealed normal cardiac sounds without murmurs, and normal breathing sounds on the left side and upper right side of the chest. Abdominal examination revealed no palpable masses or other abnormalities. No palpable lymph nodes were present. Additional physical examination revealed no other abnormalities.Laboratory tests only showed a slightly elevated serum alkaline phosphatase of 174 U?L -1 (normal value: 13-120 U?L -1 ). Serum lactate dehydrogenase, a-fetoprotein and b-human chorionic gonadotropin values were all normal; therefore, an extra-gonadal germ cell tumour was unlikely.On revision of the CT scan, there was doubt regarding the hepatic origin of the mass. Therefore, abdominal ultrasonography was performed. No focal lesions in the liver parenchyma were observed, and the liver blood flow appeared intact. In the right thoracic region, a mass was seen with variable echogenicity and rich vascularisation. Due to the high degree of vascularisation observed on the abdominal ultrasonography, no percutaneous biopsy was performed. A CT angiography was performed: first, to narrow the differential diagnosis, and, secondly, to provide the thoracic surgeon with more detailed information about vascularisation ( fig. 2). At bronchoscopy, no endobronchial abnormalities were seen. Cytological examination of the bronchial lavage showed no signs of malignancy. A bone scan was normal.Exploratory thoracotomy revealed a tumour originating from the right dorsal region, lateral from the vertebral column. A surgeon was able to remove the tumour (figs 3 and 4). Eur Respir J 2005; 26: 740-743

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A 20-year-old male with thoracic pain and a lower thoracic mass

Jong

Graaf²,

Jagt³

et al. 2005

European Respiratory Journal

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“…Nevertheless, it must be noted that the importance of positive margin status to local recurrence rates, is still a matter of debate. In contrast to other published series [2,10], a study by Gronchi et al showed that presence of microscopic disease did not affect long-term disease-free survival in patients with primary presentation of extra-abdominal desmoid tumors [11]. Primary RT is an appropriate alternative for patients who are not good surgical candidates [12].…”

Section: Discussionmentioning

confidence: 98%

Desmoid tumor of the supraclavicular region: a case report

Koukoutsis

Παππάς

Karanikas

et al. 2009

Cases J

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Desmoid tumors are rare, benign fibroblastic tumors that are locally infiltrative and can cause extensive morbidity by destruction of adjacent vital structures. Due to the rarity of these tumors, evidence regarding optimal treatment protocols is drawn from case reports and single-arm series with small patient numbers. We report a case of a patient with a desmoid tumor of the left supraclavicular region that was diagnosed and treated in our department and a review of the current literature.

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2011

Soft Tissue Tumors

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Quality of Surgery and Outcome in Extra-Abdominal Aggressive Fibromatosis: A Series of Patients Surgically Treated at a Single Institution

Cited by 326 publications

References 37 publications

A 20-year-old male with thoracic pain and a lower thoracic mass

A 20-year-old male with thoracic pain and a lower thoracic mass

Desmoid tumor of the supraclavicular region: a case report

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