Quality of sleep in primary focal dystonia: a case–control study

Avanzino, Laura; Martino, Davide; Marchese, Roberta; Aniello, Maria Stella; Minafra, Brigida; Superbo, Maria; Defazio, Giovanni; Abbruzzese, Giovanni

doi:10.1111/j.1468-1331.2009.02884.x

Cited by 61 publications

(71 citation statements)

References 30 publications

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“…Lack of correlation between PSQI and severity of dystonia in both CD and BSP patients suggested that insomnia might be a comorbidity disorder in patients with BSP or CD, which partly resemble the results of Avanzino et al. (2010). After ANCOVA analysis to avoid the influence of anxiety and depression, insomnia showed tight connection with depression, but the causal relationship between quality of sleep and depression remains unknown (Lobbezoo, Thu Thon, Remillard, Montplaisir, & Lavigne, 1996).…”

Section: Discussionmentioning

confidence: 99%

“…Besides PSQI, we used ESS to evaluate daytime sleepiness. It's interesting to find that the impairment of sleep quality did not have impact on daytime sleepiness, which was similar with another study (Avanzino et al., 2010). Overall, insomnia is a feature of primary cranial and cervical dystonia.…”

Section: Discussionmentioning

confidence: 99%

“…Avanzino et al. (2010) found BSP patients suffered from impairment in sleep duration, latency, and efficiency, while they did not find significant sleep disturbances in patients with CD. However, a small sample prospective study found that the quality of sleep was significantly impaired in patients with CD, and that the quality of sleep or daytime somnolence was not improved despite the improvement of the motor severity of CD patients (Eichenseer et al., 2014).…”

Section: Introductionmentioning

confidence: 94%

“…Sleep disorders were reported commonly in patients with dystonia (Avanzino et al., 2010; Eichenseer et al., 2014). Avanzino et al.…”

Section: Introductionmentioning

confidence: 99%

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Nonmotor symptoms in primary adult‐onset cervical dystonia and blepharospasm

et al. 2016

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BackgroundThe nature and frequency of nonmotor symptoms in primary adult‐onset cervical dystonia (CD) and blepharospasm (BSP) patients in Chinese populations remain unknown.MethodsHamilton's Depression Scale (HAMD), Hamilton's Anxiety Scale (HAMA), Addenbrooke's Cognitive Examination Revised (ACE‐R), Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale were used to evaluate NMS in 120 patients with primary focal adult‐onset dystonia (60 with BSP and 60 with CD) and 60 age‐, sex‐, and education level‐ matched healthy controls (HCs). Motor symptoms of BSP and CD patients were evaluated by Jankovic rating scale and Toronto Western Spasmodic Torticollis Rating Scale‐severity scale separately.ResultsTwenty patients had depression, and 29 patients had anxiety. The mean HAMD and HAMA scores were significantly higher in patient groups. Thirty‐six patients had cognitive decline based on the cut‐off score of 75. The total score and scores of each domain of ACE‐R were significantly lower in patient groups than that in HCs. Quality of sleep was impaired in patient groups, and patients with CD had worse quality of sleep than patients with BSP. Thirty‐three BSP patients and 43 CD patients suffered from sleep disorder separately. The frequency of excessive daytime sleepiness did not differ between patients and HCs. No significant correlation was found between NMS and motor severity in the two forms of dystonia.ConclusionsCurrent study suggests that NMS are prevalent in Chinese CD and BSP patients, and the motor severity of dystonia did not contribute to the severity of nonmotor symptoms. Assessment of nonmotor symptoms should be considered in clinical management of focal dystonia

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

“…Sleep disorders were reported commonly in patients with dystonia (Avanzino et al., 2010; Eichenseer et al., 2014). Avanzino et al.…”

Section: Introductionmentioning

confidence: 99%

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Nonmotor symptoms in primary adult‐onset cervical dystonia and blepharospasm

et al. 2016

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“…The cause of CD remains unknown but in addition to motor symptoms CD is associated with nonmotor symptoms such as sensory deficits, sleep disorders, and pain (Avanzino et al., 2010; Antelmi et al., 2016; Tinazzi, Fiorio, Fiaschi, Rothwell, & Bhatia, 2009; Patel, Jankovic, & Hallett, 2014). Impaired sensorimotor integration has been described as part of the pathophysiology of CD (Tinazzi, Rosso, & Fiaschi, 2003; Fiorio et al., 2007; Konczak & Abbruzzese, 2013).…”

Section: Introductionmentioning

confidence: 99%

Cervical sensorimotor control in idiopathic cervical dystonia: A cross‐sectional study

et al. 2017

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ObjectivesPatients with idiopathic adult‐onset cervical dystonia (CD) experience an abnormal head posture and involuntary muscle contractions. Although the exact areas affected in the central nervous system remain uncertain, impaired functions in systems stabilizing the head and neck are apparent such as the somatosensory and sensorimotor integration systems. The aim of the study is to investigate cervical sensorimotor control dysfunction in patients with CD.Material and MethodsCervical sensorimotor control was assessed by a head repositioning task in 24 patients with CD and 70 asymptomatic controls. Blindfolded participants were asked to reposition their head to a previously memorized neutral head position (NHP) following an active movement (flexion, extension, left, and right rotation). The repositioning error (joint position error, JPE) was registered via 3D motion analysis with an eight‐camera infrared system (VICON ® T10). Disease‐specific characteristics of all patients were obtained via the Tsui scale, Cervical Dystonia Impact Profile (CDIP‐58), and Toronto Western Spasmodic Rating Scale.ResultsPatients with CD showed larger JPE than controls (mean difference of 1.5°, p < .006), and systematically ‘overshoot’, i.e. surpassed the NHP, whereas control subjects ‘undershoot’, i.e. fall behind the NHP. The JPE did not correlate with disease‐specific characteristics.ConclusionsCervical sensorimotor control is impaired in patients with CD. As cervical sensorimotor control can be trained, this might be a potential treatment option for therapy, adjuvant to botulinum toxin injections.

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The clinical and sleep manifestations in children with FOXG1 syndrome

et al. 2023

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FOXG1 syndrome is a rare neurodevelopmental disorder associated with severe cognitive dysfunction, autistic behavior, and early‐onset hyperkinetic movement disorders. Patients have also been reported to experience sleep disturbances. However, these findings are mainly based on subjective caregivers' reports, and limited by small case numbers. Moreover, no studies using objective evaluation tools, such as actigraphy, have been reported. We analyzed the clinical and sleep manifestations of children with FOXG1 syndrome registered in the FOXG1 Research Foundation Patient Registry database. A total of 258 individuals with FOXG1 syndrome were included in this research. 132 (51.16%) had sleep disturbances. The more impaired of language acquisitions (absence of speech, OR: 3.99, 95%CI = 1.69–9.42, p = 0.002), hyperkinetic movement disorders (OR: 2.64, 95%CI = 1.34‐5.20 p = 0.005) and feeding difficulties (OR: 2.81, 95% CI = 1.52–5.19, p = 0.001) were significantly associated with an increase in odds of sleep disturbance after adjusting for age, sex, and antiepileptic drugs. We also performed sleep studies on six individuals with FOXG1 syndrome using The Children's Sleep Habits Questionnaire (CSHQ), the Sleep Disturbance Scale for Children (SDSC), and 7‐day data from Actiwatch. The Pittsburgh Sleep Quality Index (PSQI) and 7‐day data from Actiwatch were also used to evaluate the sleep condition of their parents. The CSHQ scores revealed bedtime resistance, sleep onset delay, sleep duration, sleep anxiety, night‐waking, and parasomnia. Sleep–wake transition disorders and disorders of initiating and maintaining sleep were also suggested by the SDSC scores. The children's actigraphy revealed short sleep durations, impaired sleep efficiency, longer wake after sleep onset, and frequent night‐waking. All caregivers reported significantly higher PSQI scores, mildly declined sleep efficiency, and shorter total sleep duration. Sleep disturbances, especially in initiating and maintaining sleep, are common in individuals with FOXG1 syndrome and their caregivers. Sleep disorders in patients with FOXG1 syndrome and their caregivers should be investigated.

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Quality of sleep in primary focal dystonia: a case–control study

Cited by 61 publications

References 30 publications

Nonmotor symptoms in primary adult‐onset cervical dystonia and blepharospasm

Nonmotor symptoms in primary adult‐onset cervical dystonia and blepharospasm

Cervical sensorimotor control in idiopathic cervical dystonia: A cross‐sectional study

The clinical and sleep manifestations in children with FOXG1 syndrome

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