Quality of oral anticoagulant therapy in patients who perform self management: warfarin versus phenprocoumon

Jensen, Christina Friis; Christensen, Thomas; Maegaard, Marianne; Hasenkam, J. Michael

doi:10.1007/s11239-008-0274-2

Cited by 12 publications

(14 citation statements)

References 23 publications

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“…[17][18][19] As PST is expensive in medical manpower as compared to PSM, we will now randomize our 180 patients currently in PST to continue in PST or self-dosing via the expert computer system, to see if quality can be maintained.…”

Section: Discussionmentioning

confidence: 99%

Home Management of Oral Anticoagulation via Telemedicine Versus Conventional Hospital-Based Treatment

Christensen

Lauterlein

Sørensen

et al. 2011

Telemedicine and e-Health

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Background and Objective: We have developed an expert computer system for the control of oral anticoagulation therapy, accessible by the patients via their own computer. To investigate if the weekly measurement and dosing of international normalized ratio (INR) at home using the online Internet-based system was superior to conventional treatment, we performed a randomized, controlled trial. Patients and Methods: All 669 patients in our anticoagulation clinic were asked to participate in the trial, providing that they had Internet access and could use the CoaguChek XS system. A total of 140 patients were included and randomized to (A) once weekly measurement and report online, (B) twice weekly measurement and report online, and (C) continued conventional treatment with INR measurement in the lab every 4 weeks and dose adjustment by letter. Results: Group A had 79.7% (95% CI 79.0-80.3) of time in therapeutic range (TTR), group B 80.2% (95% CI 79.4-80.9) of TTR, and group C 72.7% (95% CI 71.9-73.4) TTR. Groups A and B perform statistically significantly better than the conventional group C, with a difference of TTR of 7% points (p < 2.2 · 10 À16 ), whereas

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Section: Discussionmentioning

confidence: 99%

Home Management of Oral Anticoagulation via Telemedicine Versus Conventional Hospital-Based Treatment

Christensen

Lauterlein

Sørensen

et al. 2011

Telemedicine and e-Health

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“…An appropriate intensity of oral anticoagulation for most patients is difficult to obtain when INR is adjusted within a narrow therapeutic range [6]. The number of complications increase in parallel with the time spent outside therapeutic INR range [6].…”

Section: Introductionmentioning

confidence: 99%

Pattern of oral anticoagulant use following prosthetic heart valve replacement: a prospective observational study

Palappallil

Chooriyil

Kuriakose

et al. 2011

Indian J Thorac Cardiovasc Surg

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“…7 Also, number of complications increase in parallel with time spent outside therapeutic range. 8 Addition of aspirin and dipyridamol results in reduction of anticoagulation therapy, thereby decreasing the incidence of thromboembolic and bleeding complications. 9 The oral anticoagulation should be started as early as possible, and not after 10 days as reported by others 10 .…”

Section: Discussionmentioning

confidence: 99%

Role Of Acenocoumarol In Prosthetic Heart Valves

Mir¹

2016

JIMD

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Abstract:Thromboembolic and anticoagulation related bleeding problems remain one of the most frequent complications of cardiac valvular prosthesis. Which and how much drug dose should be given depends on the individual response to the drug and the complications thereof. The aim of the study was to know the outcome of patients taking Acenocoumarol as anticoagulant drugs in prosthetic heart valves. The study was conducted on the patients who were on Acenocoumarol after heart valve replacement, and the dose was adjusted as per international normalized ratio (INR). Most of the patients were in the 4 th decade of life and males were more. Seventy-three had mitral, 19 aortic, and 3 double valve replacements done. Medtronic Hall valve was the common prosthesis used in 78, followed by Bjork Shilley in 17. Acenocoumarol was the drug used in all. Seven patients developed central nervous system events, 6 patients had features of peripheral embolization of which two had surgical intervention done, two needed amputation. Complications occurred more in patients with mitral prosthesis, and were less in patients who maintained an acceptable INR of 2.5 to 3.5. Meticulous surgery, uneventful post-operative period, early anticoagulation, and maintaining an ideal INR are the gold standards in preventing thromboembolic and bleeding complications after valve replacement.

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Quality of oral anticoagulant therapy in patients who perform self management: warfarin versus phenprocoumon

Abstract: Phenprocoumon provides a higher percentage of time spent in therapeutic INR interval and a lower variation of INR-values compared with warfarin.

Cited by 12 publications

References 23 publications

Home Management of Oral Anticoagulation via Telemedicine Versus Conventional Hospital-Based Treatment

Home Management of Oral Anticoagulation via Telemedicine Versus Conventional Hospital-Based Treatment

Pattern of oral anticoagulant use following prosthetic heart valve replacement: a prospective observational study

Role Of Acenocoumarol In Prosthetic Heart Valves

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