Quality of life worsened the most severely in patients immediately after intensity-modulated radiation therapy for prostate cancer

Nakai, Yasushi; Tanaka, Nobumichi; Anai, Satoshi; Miyake, Makito; Asakawa, Isao; Morizawa, Yosuke; Torimoto, Kazumasa; Fujii, Tomomi; Hasegawa, Masatoshi; Fujimoto, Kiyohide

doi:10.2147/rru.s168651

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…Symptoms exacerbate over the course of treatment, are most severe immediately after radiation therapy, and generally improve thereafter. 5,6 Furthermore, clinical factors such as a higher prescribed radiation dose, preexisting bladder and bowel symptoms, as well as older age have been associated with increased late-onset toxicity after pelvic radiation therapy in men with prostate cancer. 6,7 Lifestyle factors including cigarette smoking as well as being overweight or obese have also been associated with increased toxicity after treatment in this patient group.…”

Section: Introductionmentioning

confidence: 99%

Effect of Exercise Adjunct to Radiation and Androgen Deprivation Therapy on Patient-Reported Treatment Toxicity in Men With Prostate Cancer: A Secondary Analysis of 2 Randomized Controlled Trials

Schumacher

Galvão

Taaffe

et al. 2021

Practical Radiation Oncology

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Physical inactivity, in addition to clinical factors, has been associated with higher levels of late pelvic symptoms in patients with prostate cancer (PCa) after radiation therapy. The aim of this study was to investigate the effect of a structured multicomponent exercise program comprised of aerobic and resistance training as well as impact loading on the prevalence and severity of symptoms commonly resulting from androgen deprivation therapy (ADT) and pelvic radiation therapy. Methods and Materials: We performed a secondary analysis of pooled data from 2 randomized controlled trials that investigated the role of exercise on treatment-related side effects in patients with PCa receiving ADT. Patients were included in the analysis if they had undergone radiation therapy during the intervention in addition to ADT. Patient-reported quality of life and functional and symptom scales were assessed using the European Organization for Research and Treatment of Cancer QLQ-C30 and PR25 before and after 6 months of exercise or usual care (UC).

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Section: Introductionmentioning

confidence: 99%

Effect of Exercise Adjunct to Radiation and Androgen Deprivation Therapy on Patient-Reported Treatment Toxicity in Men With Prostate Cancer: A Secondary Analysis of 2 Randomized Controlled Trials

Schumacher

Galvão

Taaffe

et al. 2021

Practical Radiation Oncology

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Virtual Imaging for Patient Information on Radiotherapy Planning and Delivery for Prostate Cancer

Martínez-Albaladejo

Sulé-Suso

Lines³

et al. 2021

Medical Image Understanding and Analysis

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Health-related quality of life in Japanese patients with prostate cancer following proton beam therapy: an institutional cohort study

Matsukawa

Arimura

Orita

et al. 2020

Japanese Journal of Clinical Oncology

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Objective Many treatment options have guaranteed long-term survival in patients with localized prostate cancer and health-related quality of life has become a greater concern for those patients. The purpose of this study was to reveal the health-related quality of life after proton beam therapy and to clarify the differences from other treatment modalities for prostate cancer. Methods Between January 2011 and April 2016, 583 patients were enrolled in the study and health-related quality of life outcomes using the Expanded Prostate Cancer Index Composite questionnaire were evaluated and compared with previous research targeted at Japanese patients. Results We found a significant decrease in the least square mean scores for urinary and bowel domains excluding the incontinence subscale after proton beam therapy (P < 0.0001) and recovery at a year following treatment. The scores for sexual function in patients without androgen deprivation therapy decreased each year after proton beam therapy (P < 0.0001). The scores for hormones in patients without androgen deprivation therapy remained high and those of patients with androgen deprivation therapy were lower before treatment but were comparable to those of non-androgen deprivation therapy patients at 2 years post-treatment. We found that the impact of radiotherapy including proton beam therapy on urinary condition and sexual function was lower than that of surgery. Conclusions For the first time in Japan, we investigated health-related quality of life using Expanded Prostate Cancer Index Composite questionnaires in patients with prostate cancer after proton beam therapy and compared it with other treatment modalities.

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Quality of life worsened the most severely in patients immediately after intensity-modulated radiation therapy for prostate cancer

Cited by 3 publications

References 28 publications

Effect of Exercise Adjunct to Radiation and Androgen Deprivation Therapy on Patient-Reported Treatment Toxicity in Men With Prostate Cancer: A Secondary Analysis of 2 Randomized Controlled Trials

Effect of Exercise Adjunct to Radiation and Androgen Deprivation Therapy on Patient-Reported Treatment Toxicity in Men With Prostate Cancer: A Secondary Analysis of 2 Randomized Controlled Trials

Virtual Imaging for Patient Information on Radiotherapy Planning and Delivery for Prostate Cancer

Health-related quality of life in Japanese patients with prostate cancer following proton beam therapy: an institutional cohort study

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