Quality of life with nonpharmacologic treatment of hypertension

Roel, Joseph P.; Hildebrant, Carrie L.; Grimm, Richard H.

doi:10.1007/s11906-001-0008-8

Cited by 2 publications

(2 citation statements)

References 48 publications

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“…This concern seems however not to be justified based on the experience accumulated so far [9]. This concern seems however not to be justified based on the experience accumulated so far [9].…”

Section: Adherence To Non-pharmacological Treatment Of Hypertensionmentioning

confidence: 94%

The Relevance of Long-Term Adherence to Non-Pharmacological and Pharmacological Treatment of Hypertension

Waeber¹,

Feihl²

2007

CHYR

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Current hypertension guidelines point to the necessity of achieving sustained and strict blood pressure control in every hypertensive patient. To reach this goal the patient should comply both with hygienic measures and pharmacologic treatment. This remains a difficult task, particularly since hypertension is generally asymptomatic and since any therapeutic intervention might adversely alter the patient's quality of life. Long-term persistence with antihypertensive therapy is facilated when the treatment is initiated with well tolerated antihypertensive agents, especially blockers of the renin-angiotensin system. Having a normal blood pressure during treatment is also an important determinant of persistence. This explains the growing interest for fixed-dose combinations, which have the main advantage to be at the same time efficient and well tolerated. These simple to use preparations have even gained acceptance as first-line drug regimen.

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Section: Adherence To Non-pharmacological Treatment Of Hypertensionmentioning

confidence: 94%

The Relevance of Long-Term Adherence to Non-Pharmacological and Pharmacological Treatment of Hypertension

Waeber¹,

Feihl²

2007

CHYR

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“…Hypertension (HTN) is the leading cause of cardiovascular disease [ 1 ] and strongly contributes to worldwide mortality [ 2 ]. Although dietary interventions have been related to the control of blood pressure levels [ 3 , 4 ] and reduced incidence of cardiovascular disease [ 5 ], all possible underlying molecular and cellular mechanisms involved in these interactions are still unknown.…”

Section: Introductionmentioning

confidence: 99%

Omega-3 Fatty Acids Supplementation Differentially Modulates the SDF-1/CXCR-4 Cell Homing Axis in Hypertensive and Normotensive Rats

Halmenschlager¹,

Lehnen²,

Marcadenti

et al. 2017

Nutrients

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Background: We assessed the effect of acute and chronic dietary supplementation of ω-3 on lipid metabolism and cardiac regeneration, through its influence on the Stromal Derived Factor-1 (SDF-1) and its receptor (CXCR4) axis in normotensive and hypertensive rats. Methods: Male Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR) were allocated in eight groups (of eight animals each), which received daily orogastric administration of ω-3 (1 g) for 24 h, 72 h or 2 weeks. Blood samples were collected for the analysis of the lipid profile and SDF-1 systemic levels (ELISA). At the end of the treatment period, cardiac tissue was collected for CXCR4 expression analysis (Western blot). Results: The use of ω-3 caused a reduction in total cholesterol levels (p = 0.044), and acutely activated the SDF-1/CXCR4 axis in normotensive animals (p = 0.037). In the presence of the ω-3, after 72 h, SDF-1 levels decreased in WKY and increased in SHR (p = 0.017), and tissue expression of the receptor CXCR4 was higher in WKY than in SHR (p = 0.001). Conclusion: The ω-3 fatty acid supplementation differentially modulates cell homing mediators in normotensive and hypertensive animals. While WKY rats respond acutely to omega-3 supplementation, showing increased release of SDF-1 and CXCR4, SHR exhibit a weaker, delayed response.

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Quality of life with nonpharmacologic treatment of hypertension

Cited by 2 publications

References 48 publications

The Relevance of Long-Term Adherence to Non-Pharmacological and Pharmacological Treatment of Hypertension

The Relevance of Long-Term Adherence to Non-Pharmacological and Pharmacological Treatment of Hypertension

Omega-3 Fatty Acids Supplementation Differentially Modulates the SDF-1/CXCR-4 Cell Homing Axis in Hypertensive and Normotensive Rats

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