Quality of life with biweekly docetaxel and capecitabine in advanced gastro-oesophageal cancer

Korkeila, Eija; Salminen, Tapio; Kallio, Raija; Mikkola, Maija; Auvinen, Päivi; Pyrhönen, Seppo; Ristamäki, Raija

doi:10.1007/s00520-017-3689-5

Cited by 5 publications

(3 citation statements)

References 27 publications

(37 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Five studies focused on QoL while receiving systemic therapies (71)(72)(73)(74)(75), three studies assessed QoL after surgical interventions (76)(77)(78), one study examined QoL after percutaneous liver ablation (79), two studies considered QoL during radiation treatments (80,81), two studies assessed QoL with nutritional interventions (82,83), two studies evaluated QoL in the last 6 months of life with or without the support of hospice services (84,85), and the last study examined the effects of low-frequency rotary magnetic fields on patients with symptomatic AGC (see Table 8 and Figure 5) (86). All studies were quantitative, as the only study reporting on the qualitative experiences of patients with gastric cancer did not specify that the patients in that study had AGC (87).…”

Section: Treatment Modalitiesmentioning

confidence: 99%

Palliative interventions for patients with advanced gastric cancer: a systematic review

Kopecky¹,

Monton²,

Rosman³

et al. 2022

Chin Clin Oncol

View full text Add to dashboard Cite

Background: Gastric cancer is the fifth most common cancer and the third leading cause of cancer-related death worldwide. Advanced gastric cancer (AGC) is associated with significant morbidity and mortality and is commonly accompanied by a variety of distressing symptoms. Current National Comprehensive Cancer Network (NCCN) guidelines recommend palliative treatment modalities for patients with AGC and the treatment of AGC patients should be influenced by palliative care principles. The objective of this systematic review was to explore the published literature on palliative interventions for patients with AGC.Methods: We performed a systematic literature search to identify English language studies that investigated interventions to improve or treat the symptoms caused by AGC using PubMed, Embase, and Cochrane Library databases from January 1, 2010 to August 18, 2022. Two independent reviewers performed title and abstract review, followed by full-text review and data abstraction. Overall study quality and risk of bias was assessed using published quality assessment tools.Results: We identified 10,364 studies and included 66 studies published between 2010 and 2022 for final review. Among the studies, quality of life (QoL) metrics were most commonly a secondary outcome.Twenty-three studies addressed the palliative management of bleeding with the use of radiation therapy, surgery, arterial embolization, chemotherapy, or endoscopic interventions. Twenty-two studies addressed the management of obstructive symptoms with endoscopic stenting or surgical interventions. Most of these studies were of moderate quality and included well characterized outcomes focused on symptom reduction.Five studies assessed palliative modalities to reduce the symptomatic burden of intraabdominal ascites; these studies were less well characterized, and on average low quality. Fifteen studies of mixed quality assessed QoL for patients with AGC, with only one study evaluating specialty palliative care consultation. No studies outlined the prevalence or practices of advanced care planning in this patient population. Conclusions: Patients with AGC undergo a variety of interventions aimed at palliating the symptoms associated with their diagnosis and improving their QoL. Future research on palliative interventions for patients with AGC should utilize qualitative methodologies to measure outcomes related to symptom management and QoL, further explore the patient experience of living with AGC, and delineate best practices for advanced care planning in this population.

show abstract

Section: Treatment Modalitiesmentioning

confidence: 99%

Palliative interventions for patients with advanced gastric cancer: a systematic review

Kopecky¹,

Monton²,

Rosman³

et al. 2022

Chin Clin Oncol

View full text Add to dashboard Cite

show abstract

“…Although the mean score of functional scales improved in the two treatment groups over time, there was no significant difference in emotional and global health status in the palliative group. Korkeila et al showed that treatment in advance gastri-oesophageal cancer led to the considerable alleviation in eating restrictions and pain, partial improvement in social, emotional and role functions while global health status, physical and cognative functions remainded without change ( 43 ). Global health status was worst at the baseline assessment and the mean score of social function had the lowest score in the functional scales.…”

Section: Discussionmentioning

confidence: 99%

Changes in health-related quality of life in oesophagogastric cancer patients participating in palliative and curative therapies

Asadi‐Lari

Homaee-Shandiz

Esmaeili-Hesari

2018

Med. J. Islam. Republic Iran

View full text Add to dashboard Cite

Background: Various treatments are used to prolong survival and improve quality of life (QOL). The purpose of this study was to assess the change in QOL scores in patients with Oesophagogastric (OG) cancer undergoing curative intent and palliative therapy. Methods: This was a mix-designed cohort study with a consecutive sampling of patients with OG cancer who underwent curative or palliative treatment regimens. The QOL, as a determinant of efficacy and impact of cancer care, was evaluated using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaires. QOL data were collected from the eligible subjects at three points of time. The repeated measurement test was used to compare the significance of change in scores. Results: Overall, 149 patients (54.4% male, 61.1% curative intent, 52.3% esophageal, 37.6 % gastric, 10.1% OG junction cancer; with mean age 62 year) with OG cancer were eligible for inclusion in the study. Compared to the palliative group, the curative group was more likely to have an esophageal tumor site, Squamous Cell Carcinoma, and stage 2 (versus stomach, Adenocarcinoma, and stage 4 in the palliative group). In comparing the patients' functional, global health status, and cancer symptom, considering time, group of treatment, and their mutual effect the result indicated significant difference between the intervention groups. Conclusion: Most patients with Oesophagogastric cancer are diagnosed with an incurable form of the disease. Hence in absence of curative treatment, palliative therapy is the most effective therapy to maintain patient independency and relieve pain and symptom in order to improve their QOL. The present study has shown that palliative similar to curative intervention can improve the QOL in cancer patient especially in short term.

show abstract

“…Genel sağkalımın primer sonlanım noktası olduğu randomize klinik çalışmalarda, yaşam kalitesi sonuçlarına göre hastaların ayrılması gerektiği belirtilmektedir (15) . EORTC QLQ-C30 anketi, mide kanserli hastaların alındığı ve sistemik kemoterapi rejimlerinin değerlendirildiği klinik çalışmalarda da sıkça kullanılan bir yaşam kalitesi anketidir (14,(16)(17)(18)(19)(20)(21)(22)(23) . Metastatik mide kanserinde olduğu gibi, farklı tedavi rejimleri arasında sağkalım oranlarının benzer olduğu kanserlerde, yaşam kalitesi sonuçları tedavi seçiminde çok önem kazanmaktadır.…”

Section: Introductionunclassified

The Effect of Chemotherapy on Quality of Life of the Patients with Metastatic Gastric and Colorectal Cancer

Ünnü¹,

Ünek²,

Topaloğlu³

2021

TERH

View full text Add to dashboard Cite

Objective: The self-administered questionnaires by the patients are among the most important methods to evaluate the patient’s health related quality of life. The objective of the study was to evaluate the effect of chemotherapy on quality of life of the patients receiving palliative chemotherapy with the diagnosis of metastatic gastric and colorectal cancer by using EORTC QLQ-C30. Methods: This study included 100 patients who were treated with palliative chemotherapy for the diagnosis of metastatic gastric or colorectal cancer in İzmir Tepecik Education and Research Hospital Department of Medical Oncology between 2011-2012. The EORTC QLQ-C30 questionnaire was filled twice by the patients before chemoterapy started and after chemotherapy completed. Results: When the two questionnaires were compared, it was found that global health status and physical functioning did not change after the chemotherapy. Role functioning, cognitive functioning, and social functioning impaired but emotional functioning improved (p<0.05). After the chemoterapy, scores of fatigue and constipation decreased but financial difficulties increased (p<0.05). The symptom scores of nausea-vomitting, pain, dyspnea, insomnia, anorexia, diarrhea did not change. Conclusion: The results of this study suggested that a quality of life assessment with the EORTC QLQ-C30 questionnaire would be beneficial in patients with metastatic gastric and colorectal cancer. In this way, impairments in functional scores, global health status and symptom scores that may occur after chemotherapy can be detected, clinicians can be helped to decide on the switch to chemotherapy regimens that are similar in effectiveness but have different side effects profile, the patients’ quality of life can be improved as a result of the application of the necessary palliative treatments.

show abstract

Quality of life with biweekly docetaxel and capecitabine in advanced gastro-oesophageal cancer

Cited by 5 publications

References 27 publications

Palliative interventions for patients with advanced gastric cancer: a systematic review

Palliative interventions for patients with advanced gastric cancer: a systematic review

Changes in health-related quality of life in oesophagogastric cancer patients participating in palliative and curative therapies

The Effect of Chemotherapy on Quality of Life of the Patients with Metastatic Gastric and Colorectal Cancer

Contact Info

Product

Resources

About