Quality of Life, Risk Factors and Mortality in Children with HIV/AIDS on 2nd Line Treatment, Slow Progressors and Late Presenters in Cambodian Orphanage

Abstract

Purpose of this paper was to review group of Cambodian children with AIDS -late presenters, coming to our programme with low immunologic status (CD4˂5%, and ˂100 CD4 cells) and opportunistic infections as well as children who started HAART too late according to the guidelines valid in 2003 -2005 (˂200 CD4 cells per cubic millimetre). Another aim of this study was to compare children with AIDS who are on 2 nd line HAART for risk factors, failure and outcome in comparison to children on 1 st line ARV. There was relatively low proportion of children on 2 nd line treatment since beginning of ART (27 of 140, 19%). Mortality in late presenters is higher than in non-late presenters and also opportunistic infections were higher in the group of late presenters, including HZV and TB. Relatively high proportion of slow progressors was found among included children as well.

Improved Adherence to ART in Children – Orphans with AIDS Results in the Decreasing Occurrence of Tuberculosis (Research paper)

“…Despite 10 children having a history of TB for the past 12 years, due to highly active antiretroviral therapy (HAART) all TB cases were cured after 6-0 months of combination of RIF+INH+PZA, Gene X-pert test was negative in all 31 children despite 4 having a recurrent history of TB within 6 months, all were receiving anti-TB therapy (3)(4).…”