Quality of Life Questionnaires in Breast Cancer-Related Lymphedema Patients: Review of the Literature

Cornelissen, Anouk J. M.; Kool, Melissa; Keuter, Xavier H. A.; Heuts, E. M.; Piatkowski, Andrzej; Hulst, René R W J van der; Qiu, Shan Shan

doi:10.1089/lrb.2017.0046

Cited by 60 publications

(41 citation statements)

References 38 publications

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“…This has resulted in duplication of effort, patient inconvenience, and increased resource costs. Finally, although it is generally agreed that patient reported outcomes are an important assessment tool for plastic surgery patients [23], the utility and baseline assessment of patients with secondary lymphedema of the upper extremity presenting for surgical evaluation has not been performed using validated questionnaires.…”

Section: Introductionmentioning

confidence: 99%

Preoperative Assessment of Upper Extremity Secondary Lymphedema

Wiser

Mehrara

Coriddi

et al. 2020

Cancers

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Introduction: The purpose of this study was to evaluate the most commonly used preoperative assessment tools for patients undergoing surgical treatment for secondary upper extremity lymphedema. Methods: This was a prospective cohort study performed at a tertiary cancer center specializing in the treatment of secondary lymphedema. Lymphedema evaluation included limb volume measurements, bio-impedance, indocyanine green lymphography, lymphoscintigraphy, magnetic resonance angiography, lymphedema life impact scale (LLIS) and upper limb lymphedema 27 (ULL-27) questionnaires. Results: 118 patients were evaluated. Limb circumference underestimated lymphedema compared to limb volume. Bioimpedance (L-Dex) scores highly correlated with limb volume excess (r2 = 0.714, p < 0.001). L-Dex scores were highly sensitive and had a high positive predictive value for diagnosing lymphedema in patients with a volume excess of 10% or more. ICG was highly sensitive in identifying lymphedema. Lymphoscintigraphy had an overall low sensitivity and specificity for the diagnosis of lymphedema. MRA was highly sensitive in diagnosing lymphedema and adipose hypertrophy as well as useful in identifying axillary vein obstruction and occult metastasis. Patients with minimal limb volume difference still demonstrated significantly impaired quality of life. Conclusion: Preoperative assessment of lymphedema is complex and requires multimodal assessment. MRA, L-Dex, ICG, and PROMs are all valuable components of preoperative assessment.

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Section: Introductionmentioning

confidence: 99%

Preoperative Assessment of Upper Extremity Secondary Lymphedema

Wiser

Mehrara

Coriddi

et al. 2020

Cancers

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“…In the After Mapping of the Axilla: Radiotherapy Or Surgery (AMAROS) study, 15% of patients showed clinical signs of lymphedema 1 year after axillary RT without ALND, 14% at 3 years, and 11% at 5 years (6). Interruption of the axillary lymphatic system due to breast cancer treatment results in BCRL, which has a negative effect on quality of life in breast cancer patient (26)(27)(28).…”

Section: Discussionmentioning

confidence: 99%

Dosimetric comparison of incidental axillary irradiation between three‑dimensional conformal and volumetric modulated arc techniques for breast cancer

Kim

et al. 2020

mol clin onc

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Radiotherapy techniques for breast cancer have evolved with efforts to reduce treatment-related side effects. In the present study, we conducted dosimetric analysis of incidental axillary irradiation between volumetric modulated arc therapy (VMAT) and three-dimensional conformal radiotherapy (3D-CRT). A total of 20 patients with early stage left breast cancer who underwent breast-conserving surgery followed by postoperative radiotherapy were analyzed. For VMAT plans, dose-volume constraints were not imposed on the axilla, as with 3D-CRT. We compared the dosimetric parameters of the planning target volumes, organs at risk and axillary level I-III of the two plans. VMAT showed better target coverage and a normal organ-sparing effect compared with 3D-CRT. The incidental axillary irradiation of VMAT was lower; the mean dose and the V40 Gy were significantly reduced at all axillary levels, with the exception of no difference in the maximum dose to axillary level I. In conclusion, VMAT decreased incidental axillary irradiation, even in the absence of a dose-volume constraint on the axilla, and can, therefore, decrease the risk of radiotherapy-related lymphedema. However, caution is also required because it is unclear whether this incidental axillary irradiation is beneficial for reducing recurrence on the axilla.

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“…Lymphedema is a chronic progressive condition that is invalidating and affects that quality of life physically, emotionally, and socially . Baseline treatment consists of complex physical treatment, which consists of skin care, manual lymphatic drainage, and compression garments and/or bandaging .…”

Section: Discussionmentioning

confidence: 99%

“…With the patient in the supine position, the arm next to the body and the thumb towards the ceiling, a line is drawn between the lateral epicondyle of the humerus and the mid point between the dorsal radio-ulnar joint with the third metacarpal at the long axis of the arm(Figures 4-11). Further results can be seen inTables 1 and 2.4 | DISCUSSIONLymphedema is a chronic progressive condition that is invalidating and affects that quality of life physically, emotionally, and socially 7. Baseline treatment consists of complex physical treatment, which consists of skin care, manual lymphatic drainage, and compression410 | ZELTZER ET AL.…”

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confidence: 99%

MR lymphography in patients with upper limb lymphedema: The GPS for feasibility and surgical planning for lympho‐venous bypass

Zeltzer¹,

Brussaard²,

Koning³

et al. 2018

Journal of Surgical Oncology

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Quality of Life Questionnaires in Breast Cancer-Related Lymphedema Patients: Review of the Literature

Abstract: According to the results obtained, the LyQLI and Lymph-ICF questionnaires were the two most complete and accurate questionnaires to assess QoL in patients with BCRL, because these questionnaires assess the largest number of QoL domains and specific arm symptoms.

Cited by 60 publications

References 38 publications

Preoperative Assessment of Upper Extremity Secondary Lymphedema

Preoperative Assessment of Upper Extremity Secondary Lymphedema

Dosimetric comparison of incidental axillary irradiation between three‑dimensional conformal and volumetric modulated arc techniques for breast cancer

MR lymphography in patients with upper limb lymphedema: The GPS for feasibility and surgical planning for lympho‐venous bypass

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