Quality of Life Outcomes Reported in Randomised Controlled Trials of Immunosuppressive Drug Regimens in Kidney Transplantation: A Systematic Review

Howell, Martin; Wong, Germaine; Tong, Allison; Tan, Ho Teck; Craig, Jonathan C.; Howard, Kirsten

doi:10.1097/00007890-201211271-00339

Cited by 2 publications

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“…For example, a systematic review which examined the use of PRO measures in immunosuppressive regimen trials concluded that very few randomized controlled trials had used HRQoL outcomes. Efforts to incorporate PROs into research have also often been minimized by various challenges - the same review found that when PROs such as HRQoL were included in such trials, the validity of the measures used or the clinical relevance of the results were often not considered [ 103 ]. PRO-focused research is also susceptible to the death valleys of translational research, which may be particularly true if there is no clearly established rationale or future implication(s) associated with assessing PROs.…”

Section: Introductionmentioning

confidence: 99%

Translational Research in Kidney Transplantation and the Role of Patient Engagement

Farragher

Elliott

Silver

et al. 2015

Can J Kidney Health Dis

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BackgroundTranslational research is an evolving discipline that is intended to bridge the gaps between basic science research, clinical research, and implementation in clinical practice. It is a fluid, multidirectional process that requires strong interdisciplinary collaboration to produce research that is relevant to end-users.Purpose of this reviewThis review summarizes current perspectives on translational research and outlines its relevance and importance to kidney transplantation research.Sources of informationSources of information used for this review include published reports, articles, and research funding websites.FindingsTissue typing is used as an in-depth example of how translational research has been applied in the field of kidney transplant medicine, and how it has resulted in successful implementation of diagnostic and management options for sensitized individuals undergoing kidney transplantation. The value of actively involving kidney transplant stakeholders (patients, caregivers, and clinicians) in setting research priorities and determining relevant outcomes for future investigation is also discussed.LimitationsThis is a narrative review of the literature which has been partly influenced by the perspectives and experiences of its authors.ImplicationsTranslational and patient-oriented research practices should be incorporated into future research endeavours in the field of kidney transplantation in order to create beneficial change in clinical practice and improve patient outcomes.What was known beforeTranslational research which engages patients in the investigative process can enhance the likelihood that medical discoveries will have a meaningful impact at the bedside.What this addsThis article applies current perspectives on translational research and patient engagement to the field of kidney transplantation, illustrating how these approaches have led to significant advancements in the field. It provides further justification for deliberate, targeted efforts to cross-collaborate and incorporate the patient voice into kidney transplant research.

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Section: Introductionmentioning

confidence: 99%

Translational Research in Kidney Transplantation and the Role of Patient Engagement

Farragher

Elliott

Silver

et al. 2015

Can J Kidney Health Dis

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“…The goal of transplantation is not only to ensure survival but also to enable transplanted persons to return to a meaningful and active life, although the construct of re-established normality is very personal and varies for different conditions (Boaz and Morgan, 2013). Therefore, it is necessary to assess patient-reported outcomes in a variety of intrapersonal and interpersonal domains of life, in addition to HRQoL (Howell et al, 2012), to evaluate potential risk and protective factors (Kumnig et al, 2014). Research on post-KT has addressed intrapersonal dimensions such as mental health or life satisfaction (e.g.…”

Section: Introductionmentioning

confidence: 99%

Psychosocial well-being after kidney transplantation: A matched-pair case-control study

Gremigni

Cappelli

2014

J Health Psychol

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A number of outcome studies showed that kidney transplantation is associated with improvements in health-related quality of life relative to the pre-transplant period, but comparisons with the general population produced mixed results. This study aimed to compare 30 successful (>1 year) kidney transplantation recipients with 30 matched-pair healthy controls on psychosocial well-being. Independent of gender, age and time since transplantation, transplanted patients equalled healthy people in the intrapersonal domains but scored worse in the interpersonal domains of psychosocial well-being. Identifying aspects of life that remain impaired after kidney transplantation may assist the development of interventions targeted at improving patients' adjustment.

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Quality of Life Outcomes Reported in Randomised Controlled Trials of Immunosuppressive Drug Regimens in Kidney Transplantation: A Systematic Review

Cited by 2 publications

References 0 publications

Translational Research in Kidney Transplantation and the Role of Patient Engagement

Translational Research in Kidney Transplantation and the Role of Patient Engagement

Psychosocial well-being after kidney transplantation: A matched-pair case-control study

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