Quality of Life Outcomes in Patients With Sinonasal Malignancy After Definitive Treatment

Philips, Ramez; Agarwal, Aarti; Chitguppi, Chandala; Swendseid, Brian; Graf, Alexander; Murphy, Kira; Jangro, William C.; Rhodes, Lora; Toskala, Elina; Luginbuhl, Adam; Curry, Joseph; Nyquist, Gurston; Rosen, Marc; Johnson, Jennifer M.; Rabinowitz, Mindy

doi:10.1002/lary.29339

Cited by 8 publications

(15 citation statements)

References 29 publications

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“…Philips et al , (2021) published a paper focused on the evaluation of patient's anxiety and depression via the Hospital Anxiety and Depression Scale (HADS) and the Functional Assessment Cancer Therapy - Nasopharynx (FACT-NP) score. It was found that those with advanced T-staging, single status and poor social support had worse anxiety and depression scores [50 ▪ ]. With relatively increased rates of suicidal ideation and HADS scores in Philip et al 's study, there is an urgent need for further studies, clinician awareness, depression screening, early referral to mental health services and appropriate clinical assessment.…”

Section: Introductionmentioning

confidence: 94%

Quality of life in sinonasal tumors: an up-to-date review

Chow

Tsetsos

Poutoglidis

et al. 2021

Current Opinion in Otolaryngology &Amp; Head &Amp; Neck Surgery

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Purpose of reviewTo assess the impact of benign and malignant sinonasal tumors and their management on patients' Quality of Life (QOL) as measured by Patient Reported Outcome Measures (PROMS). Recent findingsAlthough there is a growing consensus that endoscopic surgical management in carefully selected patients with sinonasal tumors is at least as (and probably more) effective than open resection, it is not clear to what extent this translates to better QOL outcomes. Earlier studies reported better outcomes in the emotional and physical function domains after endoscopic resection, and it seems that postsurgical morbidity is less in endoscopic compared to open approaches. QoL after endoscopic surgery for sinonasal and anterior skull base tumors seems to improve within several months of surgery in both benign and malignant tumor groups. However, patients with benign sinonasal tumors have a higher QOL pre and post operatively compared to those with malignancy mainly due to absence of (neo) -adjuvant radiotherapy and/or chemotherapy. Factors that seem to be associated with worse QoL include > 60 years, less than 6 months from surgery, prior and adjuvant chemo and radiotherapy, smoking history, advanced staging and malignancy. SummaryThere is not a universally accepted PROM for use in patients with sinonasal benign and malignant tumors: A variety of different PROMs have been used with different degrees of effectiveness. Most likely a combination of disease-specific (such as SNOT 22 and anterior skull base questionnaire) and generic (such as Short Form health survey questionnaire (SF-36) and Karnofsky Performance Status) health outcome measures provide the most insight into QOL of patients with sinonasal tumors. QOL of these patients appears to undergo a bimodal impact with patients experiencing an initial dip in QOL after surgical treatment followed by a slow improvement over time. However, while patients with benign tumors' return to their status quo ante QOL, this is not the case for patients with malignant tumors who stabilize at a lower than initially QOL. To a large extent this seems to be the effect of (neo) adjuvant chemo radiotherapy.

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Section: Introductionmentioning

confidence: 94%

Quality of life in sinonasal tumors: an up-to-date review

Chow

Tsetsos

Poutoglidis

et al. 2021

Current Opinion in Otolaryngology &Amp; Head &Amp; Neck Surgery

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“…After being diagnosed with sinonasal and skull base malignancies, patients have displayed increased mental health disorders (e.g., anxiety and depression), especially among women and smokers 66 . Advanced T classification and single (i.e., not married) relationship status were found to be significant predictors of anxiety and depression 67 . The Patient Health Questionnaire‐9 is a common depression screening tool used in the primary care setting, and providers may consider administering it if clinical depression is suspected 68 …”

Section: Resultsmentioning

confidence: 98%

“…66 Advanced T classification and single (i.e., not married) relationship status were found to be significant predictors of anxiety and depression. 67 The Patient Health Questionnaire-9 is a common depression screening tool used in the primary care setting, and providers may consider administering it if clinical depression is suspected. 68…”

Section: Late Effects: Neurocognitionmentioning

confidence: 99%

Current status of sinonasal cancer survivorship care

et al. 2023

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Sinonasal cancer is a heterogeneous orphan disease of diverse histologies, each with distinct clinical, oncologic, and toxicity profiles. Because of the comparative rarity of these cancers, sinonasal cancers are treated as a grouped diagnosis despite their clinical and biological heterogeneity. Multimodality treatment with a combination of surgery, chemotherapy, and/or radiotherapy is the standard‐of‐care for advanced‐stage patients but there are few surveillance or follow‐up practice guidelines or formalized survivorship care pathways. A scoping literature review was conducted via PubMed, EMBASE, and Google Scholar. A total of 112 studies were included, which were grouped along the following topics: surveillance, second primary tumors, quality of life, and symptom burden. Sinonasal cancer tends to exhibit a higher rate of local failure and occur in a delayed fashion compared to mucosal malignancies of the head and neck. Moreover, the site of failure and time‐varying risk of recurrence is histology‐specific. Following multimodality treatment of the skull base, patients may experience endocrine, visual, auditory, sinonasal, olfactory, and neurocognitive deficits, as well as psychosocial impairments that impact multiple physical and neuropsychological domains, resulting in diminished quality of life. Sinonasal cancer patients would benefit from tailored, histology‐specific survivorship programs to address the recurrence, second primary, and functional impairments resulting from disease and treatment toxicity.

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“…quality of life questionnaires in sinonasal cancer are rare. In a recent study, Philips et al (2020) found an elevated level of anxiety and depression in patients with higher T status two years after treatment. 21 Patel et al (2020) assessed treatment-related morbidity in a cohort of 129 patients with sinonasal malignancies of all histological subtypes and a follow-up of 42 months.…”

Section: Study Cohort and Treatmentmentioning

confidence: 91%

“…In a recent study, Philips et al (2020) found an elevated level of anxiety and depression in patients with higher T status two years after treatment. 21 Patel et al (2020) assessed treatment-related morbidity in a cohort of 129 patients with sinonasal malignancies of all histological subtypes and a follow-up of 42 months. In their cohort, 36% of patients required subsequent surgery for nasal obstruction or chronic sinusitis and a significantly higher incidence of complications after radiotherapy.…”

Section: Study Cohort and Treatmentmentioning

confidence: 91%

Morbidity and Oncological Outcome After Curative Treatment in Sinonasal Squamous Cell Carcinoma

et al. 2022

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Objectives Sinonasal squamous cell carcinomas are rare and aggressive tumors. Curative therapy includes surgery and radiotherapy, with high risk for local morbidity and impaired quality of life. The objective of this study was to analyze a large cohort of patients with sinonasal squamous cell carcinoma on treatment morbidity and oncological outcome. Methods Patients with sinonasal squamous cell carcinoma (n = 75) treated at a tertiary referral center between 2008 and 2019 were identified. In patients with curative treatment intent (n = 70), a chart review and analysis on patient and tumor characteristics, morbidity, and oncological outcome was performed. Results Mean follow-up was 59 months. Primary curative therapy was surgery alone (n = 18), surgery with radiation (n = 25), and primary (chemo)radiation (n = 27). Forty-two (60%) patients suffered from treatment-related morbidity; most frequent symptoms were dry nasal mucosa (20%), nasal obstruction (14.3%), and vision impairment or loss (11.5%). Patients with early disease had less morbidity (51.4 vs 71.1%; P = 0.09), a lower recurrence rate (27% vs. 48.5%; P = 0.08), and better overall survival (92.5% vs. 71.1%; P = 0.01). Conclusion Treatment-related morbidity is common after curative treatment of sinonasal squamous cell carcinomas. Early disease is beneficial in terms of occurrence and severity as multimodal treatment and recurrence can more likely be avoided.

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Quality of Life Outcomes in Patients With Sinonasal Malignancy After Definitive Treatment

Cited by 8 publications

References 29 publications

Quality of life in sinonasal tumors: an up-to-date review

Quality of life in sinonasal tumors: an up-to-date review

Current status of sinonasal cancer survivorship care

Morbidity and Oncological Outcome After Curative Treatment in Sinonasal Squamous Cell Carcinoma

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