Quality-of-Life Outcomes in Surgical vs Nonsurgical Treatment of Breast Cancer–Related Lymphedema

Fish, Morgan; Grover, Ritwik; Schwarz, Graham S.

doi:10.1001/jamasurg.2020.0230

Cited by 37 publications

(27 citation statements)

References 46 publications

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“…2 With the development of the medical industry, the prognosis of BC patients has been enhanced by comprehensive treatment based on surgery. 3,4 At the same time, a number of prognostic factors of BC and biomarkers have been proven to relate to BC. 5 But the high lethality is still worrying, BC has caused 570,000 deaths in 1 year.…”

Section: Introductionmentioning

confidence: 99%

<p>The Prognostic Value of Combination of Plasma Fibrinogen and CA19-9 in Non-Distant Metastatic Breast Cancer Patients Undergoing Surgery</p>

Zheng

Quan

et al. 2020

CMAR

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Purpose: This article aimed to study the prognostic value of preoperative plasma fibrinogen and CA19-9 in non-distant metastatic breast cancer (BC). Patients and Methods: A total of 343 non-distant metastatic BC patients were included in this study. The optimal cutoff values of plasma fibrinogen and CA19-9 were obtained by receiver operating characteristic (ROC) curve analysis. Univariate and multivariate Cox regression analyses were used to evaluate prognostic factors for overall survival (OS). Survival data were assessed using Kaplan-Meier survival analysis with the Log-rank test. Based on the cutoff values, we classified the fibrinogen-CA19-9 score as follows: 2 (both hyperfibrinogenemia and high CA19-9), 1 (either hyperfibrinogenemia or high CA19-9), and 0 (neither hypefibrinogenemia nor high CA19-9). Results: Our follow-up time totaled 10 years, the median follow-up time was 77 months (range=2-119 months), and 82 (23.9%) of 343 patients died during the follow-up period. The optimal cutoff values of plasma fibrinogen and CA19-9 were 2.805 g/L and 11.85 U/mL, respectively. The multivariate Cox analysis results suggested that there was a significant association between worse OS and elevated preoperative plasma fibrinogen and CA19-9 levels (HR=2.016, 95% CI=1.216-3.342, P=0.007; and HR=2.042, 95% CI=1.282-3.253, P=0.003). The area under the ROC curve (AUC) increased from 0.589 (for plasma fibrinogen) and 0.594 (for CA19-9) to 0.640 when these two parameters were combined. When we added this combined factor to the multivariate analysis, it was an independent prognostic factor for BC (P<0.001). According to the above results, we chose four prognostic factors to construct our nomogram. The AUC was 0.724, which indicates that the nomogram performs well. Conclusion: The combination of plasma fibrinogen and CA19-9 could be used as a valid independent prognostic factor for non-distant metastatic BC compared with either parameter alone and could easily be applied in clinical practice.

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Section: Introductionmentioning

confidence: 99%

<p>The Prognostic Value of Combination of Plasma Fibrinogen and CA19-9 in Non-Distant Metastatic Breast Cancer Patients Undergoing Surgery</p>

Zheng

Quan

et al. 2020

CMAR

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“…Moreover, the statistical, clinical and methodological heterogeneity in the form of HRQOL scales used inherent to each of the included studies prevents pooled analysis and makes quantitative and even qualitative comparisons difficult. Similar difficulties comparing post‐intervention HRQOL between operative and non‐operative treatment modalities for lymphoedema has been described in the literature 67 . Given the significant variety in surgical procedures, we do recognize that patients are likely to respond differently with regard to their post‐operative HRQOL scores.…”

Section: Discussionmentioning

confidence: 66%

Quality‐of‐life outcomes after operative management of primary and secondary lymphoedema: a systematic review

Tang

Ramakrishnan

Shayan

2021

ANZ Journal of Surgery

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Background Lymphoedema is an incurable and progressive disease that affects not only physical function but overall quality of life. Surgical treatment options for the management of lymphoedema are being increasingly performed. This study aims to review post‐operative health‐related quality of life (HRQOL) following surgical treatment of lymphoedema. Methods A systematic search of the PubMed and Medline databases was performed from the date of their inception until September 2018 to evaluate HRQOL following different surgical options for the treatment of lymphoedema. Results One hundred and thirteen articles were identified. Twenty‐one articles were included in the final review, comprising a total of 736 patients. HRQOL improvements appear to be sustained for at least 6–12 months post‐operatively. In particular, major benefits were noted in the domains based around physical functioning. Patient satisfaction similarly mirrors HRQOL improvements, following an initial dip in the immediate post‐operative period. Conclusion All surgical treatment modalities for the management of lymphoedema confer significant HRQOL improvements across a diverse range of health domains, with this critical outcome of surgery an important pre‐operative consideration. Recommendations for ongoing research are suggested.

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“…Nifuratel tablets and Baofukang suppository can be used in the treatment of vaginitis during pregnancy. Indeed, Nitfuratel is widely used in treating various types of infectious vaginitis with acceptable curative effect, while Baofukang suppository is used for treating vaginitis and hygropyretic leucorrhea [16,17].…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of combination of nifuratel tablets with Baofukang suppository on treatment and recurrence of vaginitis in pregnancy

Wang¹,

Zhang²

2022

Trop. J. Pharm Res

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Purpose: To investigate the effect and safety of a combination of Nifuratel tablets and Baofukang suppository in the treatment and recurrence of vaginitis in pregnant patients. Methods: A retrospective analysis was carried out on 100 in-patients admitted between February 2019 and April 2020. They were randomly assigned to control and study groups, with 50 in each group. The control group received Baofukang suppository treatment, whilst the study group was treated with Nifuratel tablets in addition to Baofukang suppository. The two groups were compared with regard to treatment effectiveness, incidence of adverse reactions, recurrence at 1, 2 and 3 months post-treatment; time taken for disappearance of clinical symptoms, and levels of inflammatory factors 1 week after treatment. Moreover, Mental Status Scale in Non-Psychiatric Settings (MSSNS) score, and Quality of Life Index (QLI) score were compared between the groups. Results: The study group out-performed the control group with respect to treatment effectiveness and QLI score (p < 0.05). Patients in the study group had significantly lower incidence of adverse reactions, degree of recurrence at 1, 2 and 3 months post-treatment, time taken for disappearance of clinical symptoms, expression levels of inflammatory factors, and MSSNS score, when compared to those in control group (p < 0.05). Conclusion: Combined use of Nifuratel tablets and Baofukang suppository in the treatment of pregnant patients with vaginitis leads to significant treatment efficacy and safety, and reduced recurrence and expression levels of inflammatory factors in patients.

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Quality-of-Life Outcomes in Surgical vs Nonsurgical Treatment of Breast Cancer–Related Lymphedema

Cited by 37 publications

References 46 publications

<p>The Prognostic Value of Combination of Plasma Fibrinogen and CA19-9 in Non-Distant Metastatic Breast Cancer Patients Undergoing Surgery</p>

<p>The Prognostic Value of Combination of Plasma Fibrinogen and CA19-9 in Non-Distant Metastatic Breast Cancer Patients Undergoing Surgery</p>

Quality‐of‐life outcomes after operative management of primary and secondary lymphoedema: a systematic review

Efficacy and safety of combination of nifuratel tablets with Baofukang suppository on treatment and recurrence of vaginitis in pregnancy

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