Quality-of-life Outcomes after Sinus Surgery in Allergic Fungal Rhinosinusitis versus Nonfungal Chronic Rhinosinusitis

Masterson, Liam; Egro, Francesco M.; Bewick, Jessica; Erskine, Sally; Clark, Allan; Javer, Amin R.; Philpott, Carl

doi:10.2500/ajra.2016.30.4280

Cited by 14 publications

(25 citation statements)

References 38 publications

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“…As demonstrated by Bewick et al the significantly higher Lund‐Mackay scores and number of total previous surgeries in this group support these findings . It has been reported that AFRS patients experience the most significant improvement in quality‐of‐life post‐surgery compared to other subgroups, which may reflect more aggressive initial disease and a more specialised level of surgical/medical care . These patients often necessitate early referral to tertiary centres, where they are more likely to be originally operated on by more experienced surgeons, including those with fellowship training.…”

Section: Discussionsupporting

confidence: 66%

A retrospective review of six hundred and nineteen cases to determine the prevalence and factors associated with revision endoscopic sinus surgery in AFRS vs NON‐AFRS patients

Rajwani

Manji

Finkelstein-Kulka

et al. 2017

Clinical Otolaryngology

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Section: Discussionsupporting

confidence: 66%

A retrospective review of six hundred and nineteen cases to determine the prevalence and factors associated with revision endoscopic sinus surgery in AFRS vs NON‐AFRS patients

Rajwani

Manji

Finkelstein-Kulka

et al. 2017

Clinical Otolaryngology

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“…A total of 31 studies were considered to be duplicates from the same cohort, and an additional 53 failed to meet inclusion/exclusion criteria. The final study list included 40 unique patient cohorts published from 2008 to 2016 and representing institutions from North America (n = 14), Europe (n = 12), Middle East (n = 6), Australia (n = 3), Asia (n = 3), and South America (n = 2) . The majority of studies were prospective observational cohorts (n =2 3), with the remainder being surgical arms from randomized clinical trials (n = 7), retrospective cohorts (n = 7), or case‐control studies (n = 3).…”

Section: Resultsmentioning

confidence: 99%

Sino‐Nasal outcome test‐22 outcomes after sinus surgery: A systematic review and meta‐analysis

Soler

Jones

et al. 2017

The Laryngoscope

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“…Five RCTs [14][15][16][17][18] and 25 RWE studies 65 reported mean baseline SNOT-22 scores in the moderate range. Five RCTs [19][20][21][22][23] and 17 RWE studies [48][49][50][51][52][53][54][55][56][57][58][59][60][61][62][63][64] reported severe mean baseline SNOT-22 scores. These findings were consistent with the treatment plan for CRSwNP provided by Fokkens et al 92 , which recommended surgery as treatment for patients with more severe symptoms or with polyps that are recalcitrant to medical management.…”

Section: Stratification Of Snot-22 Scores Prior To Surgerymentioning

confidence: 99%

Systematic literature review of humanistic and economic burdens of chronic rhinosinusitis with nasal polyposis

Chen

Zhou

Emmanuel

et al. 2020

Current Medical Research and Opinion

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Objectives: We conducted a systematic literature review (SLR) of randomized controlled trials and real-world evidence (RWE) studies to determine the humanistic (e.g. health-related/disease-specific quality of life [QOL]) and economic (e.g. direct and indirect costs) burdens of chronic rhinosinusitis with nasal polyposis (CRSwNP). Methods: The SLR adhered to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Embase, MEDLINE and Evidence-Based Medicine Reviews databases were searched using OVID. Relevant studies involving adult patients with CRSwNP published between 1 January 2008 and 16 February 2019 were included, with relevant conference abstracts from 1 January 2017, onward. Results: Sino-Nasal Outcomes Test (SNOT)-22 was the most frequently used disease-specific healthrelated QOL/patient-reported outcomes instrument for patients with CRSwNP. Baseline SNOT-22 scores ranged from 25 to 73 for surgical candidates and from 14 to 56 for medically managed patients with CRSwNP. Mean baseline EuroQol-5 Dimensions (EQ-5D) index for patients with CRSwNP ranged from 0.81 to 0.86, and mean baseline Short Form-6 Dimensions (SF-6D) ranged from 0.67 to 0.75. Three months (EQ-5D) and 5 years (SF-6D) post-endoscopic sinus surgery (ESS), rates increased from 0.81 to 0.89 and from 0.69 to 0.80, respectively. One year post-diagnosis, patients with CRSwNP had significantly more systemic prescriptions, underwent significantly more medical procedures, demonstrated greater health care resource utilization and had significantly greater mean health care costs compared with matched controls (all p < .001). Overall, for patients with initial ESS, CRSwNP was associated with higher disease-related expenditures compared with CRS without nasal polyposis (NP), even for patients who did not undergo revision surgery. Conclusions: This SLR identified substantial humanistic burden among surgery candidates. RWE shows that surgeries were used to treat relatively more severe CRSwNP patients as recommended by guidelines. Patient QOL is improved significantly after surgery; however, there is a lack of evidence on patients with revision surgery. Surgery is also associated with higher costs, and the presence of NP was a predictor of revision surgery. Patients with CRSwNP demonstrate greater health care resource utilization and costs compared to those with CRS without NP. Costs associated with different severity of CRSwNP and revision surgery need to be assessed further.

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Quality-of-life Outcomes after Sinus Surgery in Allergic Fungal Rhinosinusitis versus Nonfungal Chronic Rhinosinusitis

Abstract: Patients with AFRS experienced a more-prolonged QoL benefit from surgical and targeted medical intervention compared with those with CRSsNP, which may reflect the severity of inflammation that they presented with compared with other CRS subtypes.

Cited by 14 publications

References 38 publications

A retrospective review of six hundred and nineteen cases to determine the prevalence and factors associated with revision endoscopic sinus surgery in AFRS vs NON‐AFRS patients

A retrospective review of six hundred and nineteen cases to determine the prevalence and factors associated with revision endoscopic sinus surgery in AFRS vs NON‐AFRS patients

Sino‐Nasal outcome test‐22 outcomes after sinus surgery: A systematic review and meta‐analysis

Systematic literature review of humanistic and economic burdens of chronic rhinosinusitis with nasal polyposis

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