Quality of life of well-differentiated thyroid carcinoma patients

Dagan, Tal; Bedrin, Lev; Horowitz, Zeev; Chaushu, Gavriel; Wolf, Michael; Kronenberg, Jona; Talmi, Yoav P.

doi:10.1258/0022215041615137

Cited by 47 publications

(57 citation statements)

References 3 publications

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“…Compared with DTC-L patients, DTC-H patients had a significantly higher prevalence of virtually all hypothyroid symptoms listed on the test instrument. These observations are in line with those of quantitative (4,8,20,21) and qualitative (7,22) studies in the same setting. It is generally known that patients with thyroid cancer suffer troublesome physical symptoms relating to short-term hormone withdrawal (5, 7).…”

Section: Discussionsupporting

confidence: 90%

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Health-related quality of life, anxiety and depression in thyroid cancer patients under short-term hypothyroidism and TSH-suppressive levothyroxine treatment

Tagay¹,

Herpertz

Langkafel³

et al. 2005

eur j endocrinol

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Objective: Very few previous studies have compared the degree of health-related quality of life (HRQL), depression and anxiety of differentiated thyroid cancer patients (DTC) under short-term hypothyroidism and levothyroxine treatment. Methods: Using patient-completed instruments, we examined the frequency of physical complaints, HRQL, anxiety and depression in 130 DTC patients hospitalized for radioiodine therapy or wholebody diagnostics (age 52 years, female 71%) under short-term hypothyroidism (4 weeks of levothyroxine withdrawal; DTC-H) and in 100 DTC out-patients under TSH-suppressive doses of levothyroxine subsequent to radioiodine therapy (DTC-L; age 49 years, female 81%). Results: Compared with the German general population, DTC-H as well as DTC-L patients had significantly impaired HRQL. Notably, the decrease in HRQL was significantly higher in DTC-H than in DTC-L patients. Surprisingly, the prevalence of anxiety (44.6%) but not depression (17.7%) was much higher in the DTC-H patients than in the general population. In contrast to expectations, similar results for anxiety (44.0%) and depression (17.6%) were observed in the DTC-L patients. Conclusions: This mounting evidence suggests that a consistent pattern of HRQL impairment is experienced by patients with DTC. The high frequency of anxiety and the significantly reduced HRQL should be considered in the aftercare of DTC patients.

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Section: Discussionsupporting

confidence: 90%

“…However, resulting side-effects of surgical, radioactive and other means of follow-up testing may nonetheless produce undesirable implications on the patients' general well-being and quality of life. Generic quality of life and associated factors have rarely been investigated in thyroid cancer survivors (7).…”

Section: Introductionmentioning

confidence: 99%

Health-related quality of life, anxiety and depression in thyroid cancer patients under short-term hypothyroidism and TSH-suppressive levothyroxine treatment

Tagay¹,

Herpertz

Langkafel³

et al. 2005

eur j endocrinol

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“…However, in 154 DTC subjects evaluated by means of the Portuguese version of the University of Washington QoL questionnaire from four months to ten years after radioiodine ablation, Almeida et al (2009) reported a relationship between QoL and therapy when activities above 5.55 GBq were administered. On the other hand, in a previous study involving the same inventory test, Dagan et al (2004) found that age was more important than treatments in determining answers to the University of Washington QoL questionnaire.…”

Section: Discussionmentioning

confidence: 78%

“…On the other hand, few studies have evaluated QoL in DTC subjects on stabilized levo-thyroxine (L-T4) suppressive treatment a long time after primary therapies. Moreover, these studies have been hampered by the small number of subjects involved and of QoL questionnaires administered and by the type of control group chosen (Crevenna et al, 2003;Schultz et al, 2003;Dagan et al, 2004;Tan et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Five-year longitudinal evaluation of quality of life in a cohort of patients with differentiated thyroid carcinoma

Giusti

Melle

Fenocchio

et al. 2011

J. Zhejiang Univ. Sci. B

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Differentiated thyroid carcinoma (DTC) generally has a favorable outcome. Thyroid disease, treatments, stress, and comorbidity can compromise health-related quality of life (QoL) and indirectly weigh upon the outcome. From 2004 to 2008, we evaluated QoL longitudinally in 128 DTC subjects. During scheduled examinations, subjects were asked to undergo a semi-structured psychiatric interview and five rated inventories. The same examination was conducted in 219 subjects after surgery for benign thyroid pathology. Low scores represent a better QoL. DTC and control subjects were similar in terms of age, male/female ratio, concomitant psychopharmacological treatments, and frequency of psychiatric diseases. In DTC subjects, Billewicz scale (BS) scores showed an increasing trend over time, especially among females. The ad hoc thyroid questionnaire (TQ) scores were similar in both groups and did not change over time, but at the end of the study ad hoc TQ and BS were significantly related. Ad hoc TQ scores were also related to age on entry to the study. In both male and female DTC subjects, Hamilton's tests for anxiety (HAM-A), but not for depression (HAM-D), showed an improving trend. At the end of the study, HAM-A and HAM-D scores were comparable to those of the control group. HAM-A and HAM-D were both positively correlated with the stage of cancer and the time between diagnosis and treatment. Only HAM-D correlated with age on entry to the study. Kellner symptom questionnaire (KSQ) item scores were higher in DTC subjects than in controls. The change over time in the items including anxiety, somatization, depression, and hostility was significant. Somatization and hostility were more significantly reduced in DTC females than in DTC males. Hostility scores were significantly lower in DTC subjects than in controls at the end of the study. Somatization and depression were significantly related to staging on diagnosis and age on entry to the study. Our study confirms a wide variation of illness perception in DTC subjects, which is generally unrelated to the favorable clinical follow-up of the disease. Psychological evaluation during long-term follow-up improved QoL scores, which reached the same levels noted in subjects with a history of thyroid surgery for benign thyroid pathology. Our data indicate that special attention should be paid to QoL in older DTC subjects and those with more severe staging on diagnosis.

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“…Nerves, parathyroid, and surrounding structures are all at risk of injury during thyroidectomy. Injury to the RLN may occur by severance, ligation, or traction, but it should occur in < 1% of patients undergoing thyroidectomy by experienced surgeons (8,9). Transient hypocalcemia (from surgical injury or inadvertent removal of parathyroid tissue) has been reported in up to 50% of cases, but permanent hypoparathyroidism occurs in < 2% of the time.…”

Section: Discussionmentioning

confidence: 99%

Overall Survival and Complications of Thyroidectomy in Patients with Thyroid Cancer

et al. 2017

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Background: Recognizing complications, survival rates, and contributing factors would result in better diseases control in patients with thyroid cancer under thyroidectomy. Accordingly, this study was performed to determine the overall survival and complications in patients with thyroid cancer under thyroidectomy procedure. Methods: In this retrospective, 100 patients with thyroid cancer under thyroidectomy, who were admitted in the affiliated centers of cancer research centers at Shahid Beheshti University of Medical Sciences in recent 5 years from summer 2011 to summer 2016, were enrolled. Data collection was done by census sampling and the required data were collected via existing medical documents and were recorded by checklist from April 2016 to February 2017. Results: Thyroidectomy was total in 97% of the patients, and 3 were under subtotal thyroidectomy (two patients had anaplastic and 1 had micro papillary carcinoma). Twenty-four patients (24%) had some side effects, including no permanent nerve injury but transient nerve injury (Hoarseness) (14%), organ pressure due to hematoma (4%) and tracheal rupture (1%), and transient hypocalcaemia (5%). The recurrence and death were seen in 5% and 3%. The recurrence was related to side effects, but it was not related to death (P > 0.05). Conclusions:We studied overall survival and complications of thyroidectomy in 100 patients with thyroid cancer from summer 2011 to summer 2016 and compared them with statistics on the articles. Thyroidectomy completion is an important procedure in the treatment of a malignant thyroid tumor because of the high rate of contralateral involvement (23.8%). It is a procedure with zero mortality and very low complication rate, not bearing relevant risks. Totally, according to the obtained results in current study, it may be concluded that thyroidectomy complications are seen in 1 out of 20 patients, especially neck hematoma (4%) and tracheal rupture (1%). The survival in current study is good.

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Quality of life of well-differentiated thyroid carcinoma patients

Cited by 47 publications

References 3 publications

Health-related quality of life, anxiety and depression in thyroid cancer patients under short-term hypothyroidism and TSH-suppressive levothyroxine treatment

Health-related quality of life, anxiety and depression in thyroid cancer patients under short-term hypothyroidism and TSH-suppressive levothyroxine treatment

Five-year longitudinal evaluation of quality of life in a cohort of patients with differentiated thyroid carcinoma

Overall Survival and Complications of Thyroidectomy in Patients with Thyroid Cancer

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