Quality of life of survivors of malignant pleural mesothelioma in Japan: a cross sectional study

Nagamatsu, Yasuko; Oze, Isao; Aoe, Keisuke; Hotta, Katsuyuki; Kato, Katsuya; Nakagawa, Junko; Hara, Keiko; Kishimoto, Takumi; Fujimoto, Nobukazu

doi:10.1186/s12885-018-4293-x

Cited by 10 publications

(9 citation statements)

References 24 publications

(30 reference statements)

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“…Considering the findings further, the individuals’ accounts often voiced deep and pervasive feelings of psychosocial trauma that permeated and defined much of their experiences living with mesothelioma. This aligns with survey data showing that mesothelioma patients have a lower quality of life compared with healthy controls (Granieri et al, 2013; Kao et al, 2013; Nagamatsu et al, 2018; Nowak et al, 2004). Several factors are likely to contextualize and contribute toward the distress felt by individual patients, including the onset of physical symptoms that inhibit daily routine and social activity (Kao et al, 2013), intensive medical treatments that regularly present with unpleasant side-effects (Clayson et al, 2005), and an uncertain but dismal prognosis that induces feelings of mortality salience (Walker et al, 2019).…”

Section: Discussionsupporting

confidence: 89%

“…Mesothelioma bears a high symptom burden, with pronounced dyspnea, pain, fatigue, and disturbed sleep greatly reducing patient well-being and quality-of-life (Kao et al, 2013; Nagamatsu et al, 2018; Nowak et al, 2004). Moreover, both patients and their carers report poignant feelings of hopelessness that important life goals can no longer be achieved, nor problems solved (Granieri et al, 2013).…”

mentioning

confidence: 99%

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The experience of living with mesothelioma: A meta-ethnographic review and synthesis of the qualitative literature.

Lond¹,

Quincey²,

Apps³

et al. 2022

Health Psychology

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Objective: Mesothelioma is a life limiting cancer caused by previous exposure to asbestos. Due to the continued use of asbestos products internationally, the condition presents an increasing risk to global health with case numbers peaking in industrially developed nations. With the cancer reducing patient well-being, this study aimed to synthesizes the qualitative findings of studies exploring the experiences of patients living with mesothelioma to generate new conceptual insights and guide therapeutic care. Method: Thirteen databases were sys-

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Section: Discussionsupporting

confidence: 89%

mentioning

confidence: 99%

The experience of living with mesothelioma: A meta-ethnographic review and synthesis of the qualitative literature.

Lond¹,

Quincey²,

Apps³

et al. 2022

Health Psychology

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“…Fatigue was also a prominent physical symptom in our study, in common with other reports 28,29 . It is a key physical symptom predictive of survival and an established unmet need within the cancer population 9,17 .…”

Section: Independence and Support/familysupporting

confidence: 92%

“…Fatigue was also a prominent physical symptom in our study, in common with other reports. 28,29 It is a key physical symptom predictive of survival and an established unmet need within the cancer population. 9,17 Fatigue is common, with up to 86% of participants in the intervention arm of our study reporting such (from the SPARC tool), and at least 27% reporting “tiredness” in the overall cohort (from the QLQ-C30).…”

Section: Discussionmentioning

confidence: 99%

Symptom Burden and Unmet Needs in Malignant Pleural Mesothelioma: Exploratory Analyses From the RESPECT-Meso Study

Hoon

Lawrie

et al. 2020

J Palliat Care

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Objective: Malignant Pleural Mesothelioma (MPM) has a poor prognosis and high symptom burden. RESPECT-Meso was a multicenter randomized study examining the role of early specialist palliative care (SPC) on quality of life (QoL) with MPM. This is a post-hoc exploratory analysis of the symptom burden and unmet needs identified from RESPECT-Meso participants. Methods: Exploratory analysis from 174 participants using the General Health Status (GHS) measure (from the EORTC QLQ-C30 QoL questionnaire) and 87 participants using validated assessment questionnaires in those randomized to SPC. Eligibility for the study included confirmed MPM with diagnosis <6 weeks prior, performance score (PS) 0 or 1, no significant physical or psychological comorbidity. Cox proportional hazards models were derived to examine for relationships with survival. Free text was assessed using content analysis, looking for common themes and words. Results: Participants were predominantly male (79.9%), mean age 72.8 years, PS was 0 in 38%, 78% of MPM was epithelioid. At least 3 symptoms were reported in 69.8% of participants, including fatigue (81%), dyspnea (73.3%), pain (61.2%), weight loss (59.3%). Anxiety was reported by 54.7% of participants, 52.3% low mood and 48.8% anhedonia symptoms. After multivariable adjustment, only pain remained statistically significant with a hazard ratio (HR) 2.9 (95% CI 1.3-6.7; p = 0.01). For each 1 unit increase in GHS score, the HR for death was 0.987 (0.978-0.996; p = 0.006), indicating a worse reported QoL is related to shorter survival. Unmet needs were common: 25.9% wanted more information about their condition, 24.7% about their care and 21.2% about their treatment. 79.1% were concerned about the effect of their illness on family. Conclusion: There is a high symptom burden in mesothelioma despite good baseline performance status. A worse QoL is associated with a worse survival. Unmet needs are common, perhaps highlighting a need for improved communication and information sharing.

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“…This study is a part of a major study about QOL and intention of care among MPM patients. This study is a cross-sectional descriptive study that used a mailed survey [15]. In brief, an invitation to participate in the study was sent to 422 cancer hospitals in Japan; 64 hospitals (15.2%) agreed to participate.…”

Section: Methodsmentioning

confidence: 99%

Physician requests by patients with malignant pleural mesothelioma in Japan

Nagamatsu¹,

Oze²,

Aoe³

et al. 2019

BMC Cancer

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Background Malignant pleural mesothelioma (MPM) is a fatal and rare disease that is caused by the inhalation of asbestos. Treatment and care requests made by MPM patients to their physicians were collected and analyzed. Methods This cross-sectional survey was part of a larger study ( N = 133) regarding the quality of life of MPM patients. Specific responses to two open-ended questions related to patients’ requests regarding treatment and care were quantified, analyzed and divided into categories based on content. Results Responses ( N = 217) from MPM patients ( N = 73) were categorized into 24 subcategories and then abstracted into 6 categories. The majority of requests were related to patient-physician communication. Patients wanted clear and understandable explanations about MPM and wanted their physician to deliver treatment based on the patient’s perspective by accepting and empathizing with their anxiety and pain. Patients expected physicians to be dedicated to their care and establish an improved medical support system for MPM patients. Conclusion Patients with MPM had a variety of unmet needs from their physicians. Physicians who provide care to MPM patients should receive training in both communication skills and stress management. A multidisciplinary care system that includes respiratory and palliative care for MPM patients should be established. Electronic supplementary material The online version of this article (10.1186/s12885-019-5591-7) contains supplementary material, which is available to authorized users.

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Quality of life of survivors of malignant pleural mesothelioma in Japan: a cross sectional study

Cited by 10 publications

References 24 publications

The experience of living with mesothelioma: A meta-ethnographic review and synthesis of the qualitative literature.

The experience of living with mesothelioma: A meta-ethnographic review and synthesis of the qualitative literature.

Symptom Burden and Unmet Needs in Malignant Pleural Mesothelioma: Exploratory Analyses From the RESPECT-Meso Study

Physician requests by patients with malignant pleural mesothelioma in Japan

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