Quality of life of patients treated by home mechanical ventilation due to restrictive ventilatory disorders

Pehrsson, Kerstin; Olofson, Jan; Larsson, Sture; Sullivan, Marianne

doi:10.1016/0954-6111(94)90169-4

Cited by 87 publications

(77 citation statements)

References 17 publications

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“…This category contains items reflecting anxiety, irritation, low self-confidence, etc. In a previous study by PEHRSSON et al [15], patients treated with home mechanical ventilation for CAH due to scoliosis, previous polio, TB sequelae or neuromuscular diseases showed only slight dysfunction (mean value 3.8 versus 13.7 in the present study) in emotional behaviour. The patients in the present study were not yet treated.…”

Section: Discussioncontrasting

confidence: 49%

“…In this instrument a four point categorical scale indicates degrees of severity: never/almost never, sometimes, once a week and always/almost always. A sleep scale with satisfactory reliability that was created in an earlier study was also used [15]. This contains three items: difficulty in initiating sleep, difficulty in maintaining sleep and irregular sleep, with high scores indicating problems.…”

Section: Physiological Measurementsmentioning

confidence: 99%

“…The few reports concerning HRQL in patients with CAH due to neuromuscular or restrictive chest-wall disorders focus on patients already receiving treatment [15,16] and give little information about the effects of CAH per se on HRQL. Thus, there is a need for more information about the degree of dysfunction and consequent reduction of various aspects of quality of life in patients suffering from CAH.…”

mentioning

confidence: 99%

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Quality of life in patients with chronic alveolar hypoventilation

Dellborg¹,

Olofson²,

Midgren

et al. 2002

Eur Respir J

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Measurements of health-related quality of life (HRQL) have not been reported in patients with chronic alveolar hypoventilation (CAH) before starting home mechanical ventilation. The purpose of this study was to investigate quality of life in a population of such patients.Forty-four consecutive patients with CAH due to previous polio, scoliosis, healed pulmonary tuberculosis or neuromuscular disease answered a battery of condition specific and generic (Sickness Impact Profile, Hospital Anxiety and Depression scale, Mood Adjective Check List) self-report questionnaires. Spirometry, arterial blood gases and overnight oxygen saturation were measured.Patients with untreated CAH had significantly impaired HRQL compared to historical data from a healthy reference population. Sleep-related problems were frequent. Age, underlying disease, and standard bicarbonate correlated significantly with HRQL measures, albeit with modest levels of explained variance (8-37%).Patients with chronic alveolar hypoventilation due to neuromuscular or restrictive chest wall disorders had severely impaired health-related quality of life. Age, the underlying disease and severity of hypoventilation are each related to the health-related quality of life decrements. Health-related quality of life measurements add important information to traditional clinical observations.

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Section: Discussioncontrasting

confidence: 49%

Section: Physiological Measurementsmentioning

confidence: 99%

mentioning

confidence: 99%

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Quality of life in patients with chronic alveolar hypoventilation

Dellborg¹,

Olofson²,

Midgren

et al. 2002

Eur Respir J

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“…So far, only a few studies using modern, validated questionnaires have been published. These relate to respiratory failure and scoliosis [38], the impact of the type of brace treatment [6], and the results of the Scoliosis Research Society (SRS) instrument used for evaluation of surgical outcome [29] and for presenting short-term outcome in adolescent [47] and adult [1,23,31] scoliosis surgery. With limited economic means for health care and need for proof of the efficacy of treatment given, there will be an increasing need for outcome studies that focus not only on strictly medical, objectively measured outcomes, but also on HRQL.…”

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confidence: 99%

Health-related quality of life in patients with adolescent idiopathic scoliosis: a matched follow-up at least 20 years after treatment with brace or surgery

et al. 2001

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No results on long-term outcome in terms of health-related quality of life (HRQL) have previously been presented for patients treated for adolescent idiopathic scoliosis. A consecutive series of patients with adolescent idiopathic scoliosis, treated between 1968 and 1977 before the age of 21, either with distraction and fusion using Harrington rods [surgical treatment group (ST), n=156; 145 females and 11 males] or with a brace [brace treatment group (BT), n=127; 122 females and 5 males] were followed at least 20 years after completion of the treatment. Ninety-four percent of ST and 91% of BT patients filled in a questionnaire comprising the SF-36, Psychological General Well-Being Index (PGWB), Oswestry Disability Back Pain Questionnaire, parts of SRS/MODEM'S questionnaire and study-specific questions concerning the treatment, as a part of an unbiased personal follow-up examination including radiography and clinical examination. An age-and sex-matched control group of 100 persons was randomly selected and subjected to the same examinations. The results showed no differences in terms of sociodemographic data between the groups. Both ST and BT patients had a slightly, but significantly, reduced physical function using the SF-36 subscales, SF-36/Physical Component Summary (PCS) score as well as the Oswestry Disability Back Pain Questionnaire compared to the controls. Neither the mental subscales and the Mental Component Summary (MCS) score of SF-36 nor the PGWB index showed any significant difference between the groups. Forty-nine percent of ST, 34% of BT and 15% of controls admitted limitation of social activities due to their back [P<0.001 ST vs controls, P=0.0010 BT vs controls, and n.s. (P=0.024) ST vs BT], mostly due to difficulties with physical participation in activities or selfconsciousness about appearance. Pain was a minor reason for limitation. No correlation was found between the outcome scores and curve size after treatment, curve type, total treatment time or age at completed treatment. Patients treated for adolescent idiopathic scoliosis were found to have approximately the same HRQL as the general population. A minority of the patients (4%) had a severely decreased psychological well-being, and a few (1.5%) were severely physically disabled due to the back.

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“…It significantly improves both exercise tolerance and quality of life in patients with COPD. [1][2][3] The intensity of exercise training is crucial to achieve a true physiologic effect. However, in patients with severe COPD, exertional dyspnea and leg fatigue mean that the patient cannot maintain intensity of training for enough time to yield a physiologic training effect.…”

Section: Introductionmentioning

confidence: 99%

Physical Training and Noninvasive Ventilation in COPD Patients: A Meta-Analysis

et al. 2013

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BACKGROUND: Exercise training improves both exercise tolerance and quality of life in patients with COPD. The intensity of exercise training is crucial to achieve a true physiologic effect. However, in COPD patients, exertional dyspnea and leg fatigue mean that the patient cannot maintain intensity of training for enough time to yield a physiologic training effect. The use of noninvasive ventilation (NIV) support has been proposed as an alternative strategy to improve exercise tolerance and respiratory and cardiovascular performances. The first aim of our meta-analysis was to evaluate exercise training with NIV in terms of physiologic effects after the completion of a pulmonary rehabilitation program. The second aim was to investigate the dose-response relationship between physical improvement and training intensity. METHODS: Literature research was performed using MEDLINE, Embase, and CINAHL. Meta-analysis and meta-regressions were performed using random effects models. RESULTS: Eight studies provided a proper description of a training schedule in stable COPD patients. A similar effect between NIV and placebo was observed for the outcomes considered despite differences between studies. However, subjects experienced a relevant and statistically significant improvement after rehabilitation for almost all of the outcomes considered. Heart rate (6 beats/min [95% CI 0.94 -11.01], P ‫؍‬ .02), work load (9.73 W [95% CI 3.78 -15.67], P < .001), and oxygen consumption (242.11 mL/min [95% CI 154.93-329.9], P < .001) significantly improved after training. Improvements in heart rate and work load were significantly correlated to training intensity. CONCLUSIONS: Given the small number of available studies, the small sample sizes, and the complete absence of power calculation, we think that this topic deserves a more in-depth investigation. Randomized clinical trials with larger sample sizes based on statistical power calculations and designed to investigate the effect of training duration and intensity on rehabilitation are needed to confirm results in this important field.

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Quality of life of patients treated by home mechanical ventilation due to restrictive ventilatory disorders

Cited by 87 publications

References 17 publications

Quality of life in patients with chronic alveolar hypoventilation

Quality of life in patients with chronic alveolar hypoventilation

Health-related quality of life in patients with adolescent idiopathic scoliosis: a matched follow-up at least 20 years after treatment with brace or surgery

Physical Training and Noninvasive Ventilation in COPD Patients: A Meta-Analysis

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