Quality of life of COVID 19 patients after discharge: Systematic review

Nandasena, H. M. R. K. G.; Pathirathna, Malshani L.; Atapattu, A M M P; P.T.S.Prasanga, P.T.S.Prasanga

doi:10.1371/journal.pone.0263941

Cited by 74 publications

(74 citation statements)

References 41 publications

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“…Regarding QoL, in the present study it was observed that the mean score of both subdomains and summary scores of SF-36 were above 50, meaning that patients reported good QoL in comparison to the general population. This finding contradicts the one in a previous systematic review that showed that regardless of the time since discharge or healing, the post-COVID-19 patients’ quality of life was considerably altered [ 8 ]. Our findings can partially be explained by the fact that 88.7% of the participants were living with their spouse or their spouse and children.…”

Section: Discussioncontrasting

confidence: 87%

“…Female sex, advanced age, the existence of co-morbidities, ICU admission, extended ICU stay, and mechanical ventilation were the most common factors linked with a low level of QoL. Physical role and physical function were found to be the most and least affected domains of QoL in studies conducted using the SF-36, respectively [ 8 ]. Another study which aimed to assess COVID-19’s influence on the quality of life (QoL) of survivors, their partners, and family members, concluded that the virus had a long-term negative influence on COVID-19 survivors physical and mental health.…”

Section: Introductionmentioning

confidence: 99%

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Perceived Symptoms, Mental Health and Quality of Life after Hospitalization in COVID-19 Patients

Fradelos

Boutlas

Tsimitrea

et al. 2022

JPM

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Patients recovering from novel coronavirus are reporting a variety of symptoms such as cough, dyspnea, myalgia as well as psychological distress and poor quality of life. The aim of this study is to assess quality of life and psychological distress in COVID-19 survivors and the sociodemographic and clinical characteristics that affect COVID-19 survivors’ mental health status and quality of life. A quantitative study was conducted among COVID-19 survivors, who had previously been admitted to the University Hospital of Larissa, Greece. Data were collected via a questionnaire consisting of three-parts. The first part consisted of questions about the demographic characteristics. The second part was the SF-36 QoL index. The third part was the Symptom Checklist-90r (SCL 90-R). In addition, clinical information such as the length and the department of hospitalization, days since discharge and pulmonary function (spirometry values) were recorded. From a total of 145 patients, 60% were male, aged 59.72 ± 12.74 and 78.6% of them were married; the majority had completed secondary education, 35.9% were pensioners and 58.6 were living in urban areas. The most frequently reported symptoms were fatigue (67.6%) and pain (44.8%) and 11.7% were experiencing psychological distress. Pain, loss of smell, mandatory education, ICU admission, female gender and the experiencing of skin disturbance are associated with poor physical QoL among COVID-19 recovered patients. Greek COVID-19 previously hospitalized patients were reporting several symptoms associated with COVID-19. Good QoL and mental health were also reported. Physical pain, loss of smell and female gender were associated with poor QoL and psychological distress.

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Section: Discussioncontrasting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Perceived Symptoms, Mental Health and Quality of Life after Hospitalization in COVID-19 Patients

Fradelos

Boutlas

Tsimitrea

et al. 2022

JPM

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“…The current findings have also indicated that a few months after hospital discharge, females have higher rates of persistent symptoms than males. Nandasena et al [22] showed a contradictory result where six out of 12 of the studies found an association with female gender. However, some studies have found a similar risk between males and females to develop persistent symptoms.…”

Section: Discussionmentioning

confidence: 97%

The Persistent Symptoms and Decreased Quality of Life of COVID-19 Patients (A 3-month Follow-up after Discharge)

Farhanah

Budiman²,

Sofro

et al. 2022

Open Access Maced J Med Sci

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Most coronavirus disease 2019 (COVID-19) patients are still experiencing persistent clinical symptoms even after being discharged from the hospital. Previous studies have reported the remaining symptoms in 29%–93% of patients. This condition can have a major impact on a patient’s ability to perform daily activities and have a deleterious effect on their quality of life (QoL). Objectives: This study aimed to evaluate persistent symptoms and QoL of COVID-19 patients 3 months after discharge from Dr. Kariadi Hospital Semarang, Central Java, Indonesia. Methods: Confirmed COVID-19 patients were enrolled in this prospective cohort study after discharge from Dr. Kariadi Hospital Semarang from March 1 to May 15, 2021. Telephone interviews were conducted each week in the first month, and every 2 weeks in the second and third months regarding persistent symptoms. EQ-5D-5L questionnaires were completed and evaluated every month for 3 months after hospital discharge. Results: Of the 104 patients enrolled, 55% were male, with a mean age of 48.96 years. The incidence of persistent symptoms in the first, second, and third months was 49%, 31.7%, and 25%, respectively. The most common persistent symptoms were fatigue, cough, shortness of breath, and nausea. The characteristics of the patients included being overweight/obese, having one or more comorbidities, having five or more symptoms classified as moderate COVID-19, and requiring supplemental oxygen during hospitalization. Based on the EQ-5D questionnaire, most patients reported worsening in the quality of their ability to perform usual activities, feelings of pain/discomfort, and anxiety/depression. The total values of the EQ-5D and EQ-VAS indices were lower than those of the Indonesian general population, indicating a decrease in QoL. Conclusions: The patients developed persistent symptoms and decreased quality of life during the 3-month following hospital discharge. Keywords: persistent symptoms, EQ-5D-5L, QoL

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“…Another study found that HR-QoL was substantially poorer 8.1 (±3.2) months after the acute episode [27]. In both systematic review and meta-analysis studies, HR-QoL was considerably poorer in Long COVID-19 patients especially in those with fatigue and admission to critical care units, with up to 37% (95% confidence interval: 18 to 60%) of the patients exhibiting decreased HR-QoL [28–30]. In neuropsychiatric disorders, including affective disorders and schizophrenia, lowered HR-QoL is substantially linked with the severity of depression, chronic fatigue, anxiety, and physiosomatic symptoms, as well as immune- inflammatory and nitro-oxidative pathways [31–33].…”

Section: Introductionmentioning

confidence: 99%

Lowered quality of life in Long COVID is strongly predicted by affective symptoms and chronic fatigue syndrome which are associated with inflammatory processes during the acute infectious phase and consequent neuroimmunotoxic pathways

Maes

Al-Rubaye²,

Almulla

et al. 2022

Preprint

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The physio-affective phenome of Long COVID-19 is predicted by a) immune-inflammatory biomarkers of the acute infectious phase, including peak body temperature (PBT) and oxygen saturation (SpO2), and b) the subsequent activation of immune and oxidative stress pathways during Long COVID. The purpose of this study was to delineate the effects of PBT and SpO2 during acute infection, as well as increased neurotoxicity on the physical, psychological, social and environmental domains of health-related quality of life (HR-QoL) in people with Long COVID. We recruited 86 participants with Long COVID and 39 normal controls, assessed the WHO-QoL-BREF (World Health Organization Quality of Life Instrument-Abridged Version) and the physio-affective phenome of Long Covid (comprising depression, anxiety and fibromyalgia-fatigue rating scales) and measured PBT and SpO2 during acute infection, and neurotoxicity (NT, comprising serum interleukin (IL)-1β, IL-18 and caspase-1, advanced oxidation protein products and myeloperoxidase, calcium and insulin resistance) in Long COVID. We found that 70.3% of the variance in HR-QoL was explained by the regression on the physio-affective phenome, lowered calcium and increased NT, whilst 61.5% of the variance in the physio-affective phenome was explained by calcium, NT, increased PBT, lowered SpO2, female sex and vaccination with Astra-Zeneca and Pfizer. The effects of PBT and SpO2 on lowered HR-QoL were mediated by increased NT and lowered calcium yielding increased severity of the physio-affective phenome which largely affects HR-QoL. In conclusion, lowered HR-Qol in Long COVID is largely predicted by the severity of neuro-immune and neuro-oxidative pathways during acute and Long COVID.

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Quality of life of COVID 19 patients after discharge: Systematic review

Cited by 74 publications

References 41 publications

Perceived Symptoms, Mental Health and Quality of Life after Hospitalization in COVID-19 Patients

Perceived Symptoms, Mental Health and Quality of Life after Hospitalization in COVID-19 Patients

The Persistent Symptoms and Decreased Quality of Life of COVID-19 Patients (A 3-month Follow-up after Discharge)

Lowered quality of life in Long COVID is strongly predicted by affective symptoms and chronic fatigue syndrome which are associated with inflammatory processes during the acute infectious phase and consequent neuroimmunotoxic pathways

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