Quality of life of adolescents with end-stage renal disease and kidney transplant

Abstract

The health-related quality of life (HRQOL) of adolescents with end-stage renal disease (ESRD) is an important marker of disease burden. Our aims were to investigate HRQOL in a group of children and adolescents with ESRD and to compare them with the reference population norms. Ours was a cross-sectional study of 81 patients aged 10 years to 21 years with ESRD (68 with kidney transplants and 13 on dialysis) at five Spanish paediatric nephrology centres. HRQOL was investigated with the Spanish version of the child health and illness profile, adolescent edition (CHIP-AE). Clinical variables such as underlying diagnosis, number of rejection episodes, pre-emptive transplantation, anaemia and height were also analysed. No differences were found between patients with kidney transplants and their healthy peers in any domain or sub-domain of CHIP-AE. The group on dialysis scored lower than healthy controls and patients with transplants for satisfaction with health. Discomfort was higher in patients with transplants who had suffered one rejection episode. Physical discomfort was increased in anaemic patients with transplants. Short patients scored less in the satisfaction domain, with lower self-esteem and lower satisfaction with health. Adolescents with kidney transplants had better satisfaction with health than the group on dialysis, which matched the level of a healthy population. Further long-term prospective research is warranted.

Children and adolescents on hemodialysis: attributes associated with quality of life

“…In this study, the dimensions had to be considered in general for children and adolescents, because there are no specific dimensions, once the instrument to be built is designated to the age group of 8 to 18 years. Regarding the theme water and food restrictions, the statements showed diet restrictions to be followed, that represented for a major part of patients, once it is one of the hardest steps in the treatment, as it is highly restrictive, low sodium and with low water ingestion, generating sadness, irritability, anxiety and insecurity (13)(14) . Those nutritional recommendations impose changes in lifestyle, in opposition to the preferences and old eating habits (15) .…”

Quality Of Life Of Children With Chronic Kidney Disease

“…A study conducted with 81 children who had CKD, in different types of treatment, and 901 healthy children, in the control group, observed no significant difference between the transplanted group and the healthy one, with the health-related score being lower in the group of children subjected to dialysis compared to transplanted and healthy ones [7]. Another study verified worse scores as to self-esteem, physical perception and physical activities within the group with CKD compared to the control group [12].…”

“…This is an integrative literature review, which contributes to the deepening of knowledge on the investigated object, evidencing conclusions of the literature corpus on a specific phenomenon, and allows identifying gaps in the knowledge about the subject being studied [7]. The operationalization of this review comprehended the following stages: theme identification and selection of the research questions, establishment of inclusion and exclusion criteria of the studies, definition of information to be extracted from selected studies, analysis of included studies, discussion of results, and review presentation [8].…”

Changes in Matrix Metalloproteinases and Their Inhibitors in Kidney Transplant Recipients

“…1,2 Kidney transplant has a good outcome, giving a better quality of life, especially to young persons. 3,4 During the last decade, renal allograft survival rates have increased significantly at 1 year after transplant. 5,6 This is related to improvements in tissue typing, better understanding of immunology of the transplant, the use of more-potent immunosuppressive regimens, and better clinical management of recipients preoperatively and postoperatively.…”