Quality of life of 125 adults surviving 6–18 years after bone marrow transplantation

Bush, Nigel; Haberman, Mel; Donaldson, Gary; Sullivan, Keith M.

doi:10.1016/0277-9536(94)00153-k

Cited by 170 publications

(146 citation statements)

References 28 publications

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“…The literature is inconsistent regarding this issue: some studies show a better sleep quality of men, 15,39 whereas others describe no differences regarding concerning gender. 6,36,40 Our results indicate different temporal courses of sleep quality regarding the type of transplant. Sleep difficulties of participants receiving an allogeneic transplant were less pronounced before admission and worse during the inpatient treatment compared with patients who received an autologous transplant.…”

Section: Discussionmentioning

confidence: 68%

Sleep disturbances and emotional distress in the acute course of hematopoietic stem cell transplantation

Rischer

Scherwath

Zander

et al. 2009

Bone Marrow Transplant

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Recent research has shown that patients undergoing hematopoietic SCT (HSCT) experience multiple symptoms that can affect the sleep quality adversely. This study investigated the sleep quality of patient in the acute course of HSCT, and measured the impact of sociodemographic, medical, physical and psychological factors. Fifty patients were assessed before admission, 44 participated during inpatient treatment and 32 on day 100 ( ± 20) posttransplantation. Measuring instruments included the Pittsburgh Sleep Quality Index (PSQI) and a sleep diary (sleep quality), the European Organization for Research and Treatment of Cancer Quality of Life QuestionnaireCore 30 (health-related quality of life), the Hospital Anxiety and Depression Scale -German version (anxiety/depression) and the German version of the Cancer and Treatment Distress Scale (treatment-specific distress). The prevalence of sleep disturbances was 32% before admission, 77% during the hospital stay and 28% after discharge. Difficulty in maintaining sleep was the most intense sleep problem during the inpatient phase. This was mainly caused by disturbing noises and need to use the bathroom frequently. Sleep problems were significantly worse during the hospital stay compared with the other measurement points in time (Po0.001). A significant interaction was seen between the time course of sleep disturbances and the type of transplantation (P ¼ 0.001). The findings suggest that sleep disturbances after HSCT are particularly associated with physical functioning, fatigue and treatment-specific distress, and factors that contribute to sleep difficulties in the general population seem to be less important.

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Section: Discussionmentioning

confidence: 68%

Sleep disturbances and emotional distress in the acute course of hematopoietic stem cell transplantation

Rischer

Scherwath

Zander

et al. 2009

Bone Marrow Transplant

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“…Conversely, both Hodgkin and leukemia survivors 14 and bone marrow transplant patients are apt to have more distress, especially in the presence of physical sequelae and disability. [15][16][17][18][19][20][21][22] Although most cancer survivors are able to adjust well to their cancer experience, research suggests that distress may vary from negligible in some groups to as much as 30 -40% in others. 21 Psychosocial concerns of cancer survivors relate to a wide range of issues: possible late effects of treatment, neuropsychological and cognitive sequelae, changes in body image, psychological reaction to having had a life-threatening illness, and complications accompanying survivors' reentry into preillness social, occupational, and family roles.…”

Section: Psychosocial Concerns Of Survivorsmentioning

confidence: 99%

“…40,38 Problems with sexual functioning have also been reported by 26 -82% BMT survivors. 31,[15][16][17][18] Two years after completion of active treatment, 42% of BMT survivors reported decreased sexual desire, 17% complained of decreased sexual functioning, 25% reported inability to function sexually, and 33% reported experiencing difficulties with their partners over issues of sexuality. Male BMT survivors frequently report difficulties with achieving erection and ejaculation; whereas female BMT survivors report vasomotor difficulties, pain during intercourse, vaginal dryness, and hot flashes.…”

Section: Concerns About Sexualitymentioning

confidence: 99%

Pathways for psychosocial care of cancer survivors

Holland

Reznik

2005

Cancer

132

105

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“…Much of the QOL literature involving patients with other types of malignancies has focused on allogeneic as opposed to autologous transplants, [14][15][16][17][18] which are less commonly used for myeloma patients. Moreover, in many studies, the time frame for assessment has centered on the intermediate 19 or, more typically, the long-term post transplant period, 15,16,[20][21][22][23] with fewer studies examining the critical interval before transplantation.…”

mentioning

confidence: 99%

“…Moreover, in many studies, the time frame for assessment has centered on the intermediate 19 or, more typically, the long-term post transplant period, 15,16,[20][21][22][23] with fewer studies examining the critical interval before transplantation. Levels of distress and psychosocial morbidity appear to be especially high during this period, 18,24,25 which warrants increased attention from investigators to help guide clinical services, inform patients about what to expect, and establish baselines to assess subsequent changes.…”

mentioning

confidence: 99%

Psychosocial adjustment and quality of life among multiple myeloma patients undergoing evaluation for autologous stem cell transplantation

Sherman

Simonton

Latif

et al. 2004

Bone Marrow Transplant

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Summary:Stem cell transplantation has assumed a prominent place in the treatment of multiple myeloma, but relative to patients with other malignancies there is surprisingly little information about the adjustment difficulties and qualityof-life changes that these patients experience. This study examined psychosocial and functional deficits among myeloma patients assessed at a uniform period during their initial diagnostic evaluation, prior to beginning protocols at a transplant center. Validated self-report measures and clinician rating scales were used to assess 213 patients. Outcomes evaluated included emotional distress (Hospital Anxiety and Depression Scale, Brief Symptom Inventory), depression (Hamilton Depression Rating Scale), physical functioning, pain, and energy (SF-12). A significant proportion of patients experienced compromised psychosocial and physical functioning. Roughly one-third reported clinically elevated levels of distress, anxiety, and depression. In all, 59% scored below age-adjusted norms for daily physical functioning, 58% reported at least moderate levels of pain, and over 80% noted at least moderate fatigue. Clinical and demographic correlates of these outcomes were examined. These findings are among the first to characterize quality-of-life outcomes among myeloma patients in the transplant setting, and indicate that many patients experience considerable supportive care needs even prior to beginning aggressive regimens. Results highlight the importance of early screening. Bone Marrow Transplantation (2004) 33, 955-962.

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Quality of life of 125 adults surviving 6–18 years after bone marrow transplantation

Cited by 170 publications

References 28 publications

Sleep disturbances and emotional distress in the acute course of hematopoietic stem cell transplantation

Sleep disturbances and emotional distress in the acute course of hematopoietic stem cell transplantation

Pathways for psychosocial care of cancer survivors

Psychosocial adjustment and quality of life among multiple myeloma patients undergoing evaluation for autologous stem cell transplantation

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