Quality‐of‐life issues in survivors to anaphylactic reactions to drugs

Baiardini, Ilaria; Gaeta, Francesco; Molinengo, Giorgia; Braido, Fulvio; Canonica, Giorgio Walter; Romano, Antonino

doi:10.1111/all.12610

Cited by 23 publications

(17 citation statements)

References 13 publications

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“…Adolescents also report a lack of knowledge and fear about using an adrenaline auto‐injector and low confidence in asking about ingredients in foods which can hamper effective self‐management . Similar findings regarding the impact on QoL have been reported for those with anaphylaxis to venom and to drugs …”

Section: Introductionsupporting

confidence: 52%

“…12,13 Similar findings regarding the impact on QoL have been reported for those with anaphylaxis to venom 14 and to drugs. 15,16 Only one study has examined the psychological experience of anaphylaxis in adult patients. Walklet et al 17 interviewed seven adult patients with anaphylaxis to venom, drugs, food-dependent exercise-induced anaphylaxis or spontaneous anaphylaxis.…”

mentioning

confidence: 99%

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“It's not an illness, it's just bad luck”: The impact of anaphylaxis on quality of life in adults

Knibb

Huissoon

Baretto

et al. 2019

Clin Experimental Allergy

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Background An increasing number of adults are being diagnosed with anaphylaxis, but its impact on health‐related quality of life (HRQol) is not known. Objective The aim of this study was to explore the impact of anaphylaxis on HRQoL of newly diagnosed adults. Methods Interviews were conducted with 13 adults (aged 40‐71; five males) with anaphylaxis (meeting WAO diagnostic criteria) to drugs, food, venom or spontaneous anaphylaxis, recruited using purposive sampling from allergy clinics in Birmingham, UK. Data were transcribed verbatim and analysed using thematic analysis. Results Four themes were generated from the analysis: the journey from fear to frustration; the need to maintain a healthy identity; control over uncertainty; and the supportive role of others. Participants described their first experiences of anaphylaxis as frightening. Managing the condition was associated with frustration and anxiety, in part due to uncertainty regarding when anaphylaxis might occur. Participants did not consider their allergy as an illness and wanted to retain an identity as a healthy person. They felt a strong need to have control over their anaphylaxis so that it did not take over their lives. The support from others was extremely important, but a lack of understanding of anaphylaxis sometimes hindered that support. Conclusions and Clinical Relevance Anaphylaxis has an adverse impact on the HRQoL of adults irrespective of the cause. More information about anaphylaxis and its management from healthcare professionals may help patients gain a sense of control over their condition and reduce the worry and anxiety associated with it.

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Section: Introductionsupporting

confidence: 52%

mentioning

confidence: 99%

“It's not an illness, it's just bad luck”: The impact of anaphylaxis on quality of life in adults

Knibb

Huissoon

Baretto

et al. 2019

Clin Experimental Allergy

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show abstract

“…Darüber hinaus senkt bereits der Verdacht auf eine BLA-Allergie die Lebensqualität betro ener Patienten, unter anderem durch gesteigerte Angst vor einer Behandlung mit Arzneimitteln [18].…”

Section: Hintergrundunclassified

S2k-Leitlinie: Diagnostik bei Verdacht auf eine Betalaktamantibiotika-Überempfindlichkeit

Wurpts¹,

Aberer²,

Jakob³

et al. 2019

Allergo J

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“…Moreover, already the suspicion of BLA allergy reduces quality of life in affected patients due to greater anxiety regarding drug treatment [18].…”

Section: Introductionmentioning

confidence: 99%

Guideline on diagnostic procedures for suspected hypersensitivity to beta-lactam antibiotics

et al. 2019

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Guideline on diagnostic procedures for suspected hypersensitivity to beta-lactam antibiotics 121 guidelines Abstract This guideline on diagnostic procedures for suspected beta-lactam antibiotic (BLA) hypersensitivity was written by the German and Austrian professional associations for allergology, and the Paul-Ehrlich Society for Chemotherapy in a consensus procedure according to the criteria of the German Association of Scientific Medical Societies. BLA such as penicillins and cephalosporins represent the drug group that most frequently triggers drug allergies. However, the frequency of reports of suspected allergy in patient histories clearly exceeds the number of confirmed cases. The large number of suspected BLA allergies has a significant impact on, e.g., the quality of treatment received by the individual patient and the costs to society as a whole. Allergies to BLA are based on different immunological mechanisms and often manifest as maculopapular exanthema, as well as anaphylaxis; and there are also a number of less frequent special clinical manifestations of drug allergic reactions. All BLA have a beta-lactam ring. BLA are categorized into different classes: penicillins, cephalosporins, carbapenems, monobactams, and beta-lactamase inhibitors with different chemical structures. Knowledge of possible cross-reactivity is of considerable clinical significance. Whereas allergy to the common beta-lactam ring occurs in only a small percentage of all BLA allergic patients, cross-reactivity due to side chain similarities, such as aminopenicillins and aminocephalosporins, and even methoxyimino cephalosporins, are more common. However, the overall picture is complex and its elucidation may require further research. Diagnostic procedures used in BLA allergy are usually made up of four components: patient history, laboratory diagnostics, skin testing (which is particularly important), and drug provocation testing. The diagnostic approach-even in cases where the need to administer a BLA is acute-is guided by patient history and risk-benefit ratio in the individual case.

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Quality‐of‐life issues in survivors to anaphylactic reactions to drugs

Cited by 23 publications

References 13 publications

“It's not an illness, it's just bad luck”: The impact of anaphylaxis on quality of life in adults

“It's not an illness, it's just bad luck”: The impact of anaphylaxis on quality of life in adults

S2k-Leitlinie: Diagnostik bei Verdacht auf eine Betalaktamantibiotika-Überempfindlichkeit

Guideline on diagnostic procedures for suspected hypersensitivity to beta-lactam antibiotics

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