Quality of Life Instruments and Trajectories After Pancreatic Cancer Resection

Abstract

This systematic review aimed to investigate the instruments available to measure quality of life (QOL) after pancreatic cancer surgery and to describe short-and long-term QOL outcomes. A comprehensive literature search was completed using PubMed, Embase, and Medline from inception to March 2019. Studies investigating QOL outcomes in patients undergoing pancreatic cancer surgery who were 18 years or older were included. The main outcomes of interest were QOL instruments and short (≤6 months) and long term (>6 months) QOL outcomes. The overarching domains of physical, psychosocial, overall QOL, symptoms, and other were used to summarize QOL outcomes. Thirty-five studies reporting on 3573 patients were included. Fifteen unique QOL instruments were identified, of which 4 were disease-specific instruments. Most of the included studies reported no changes in QOL at short-and long-term follow-ups for the overarching domains. No difference in QOL outcomes was reported between different surgical approaches, except laparoscopic versus open distal pancreatectomy, and pancreaticoduodenectomy versus distal pancreatectomy. There are a wide range of instruments available to measure QOL outcomes in pancreatic cancer surgical patients, although only few are disease-specific. Most of the included studies reported no significant changes in QOL outcomes at short-or long-term follow-ups.

Health-Related Quality of Life in Locally Advanced Gastric Cancer: A Systematic Review

“…Primary outcomes of the study were: (1) short-term impact of treatment on HRQOL; (2) long-term impact of treatment on HRQOL. Based on available literature, short-term HRQOL was defined as HRQOL scores within 6 months after treatment [ 19 ]. Long-term HRQOL was defined as HRQOL scores more than 6 months after treatment.…”

Global status of research on gastrointestinal cancer patients’ quality of life: A bibliometric and visual analysis from 2003 to 2023

“…In recent decades, a growing number of researchers have been paying attention to GI cancer patients’ QoL, including the development, translation, and validation of measurement tools [ [8] , [9] , [10] ], the investigation of the current status and influencing factors of QoL [ 11 , 12 ], the exploration of pathways that affect QoL [ 13 , 14 ], the trial of treatment methods [ 15 , 16 ] and interventions [ 17 , 18 ] for QoL. Although there have been some qualitative reviews summarizing the efficacy of treatment methods [ 19 , 20 ], the effectiveness of interventions such as diet, exercise, and nursing modes [ [21] , [22] , [23] ], as well as the measurement tools [ 24 , 25 ], status [ 24 , 26 ], and influencing factors [ [27] , [28] , [29] ] of QoL, the research direction and hotspots in this field are still unclear, and the bibliometric method has not been applied to quantitatively describe the research status of QoL for GI cancer survivors.…”

Quality of life after pancreatoduodenectomy: Is the outcome predetermined by the diagnosis?

“…5 QoL is of major importance in these patients for both patient selection and counseling on realistic postoperative expectations. The vast majority of the literature has focused on malignant indications for this surgery, 6,7 and comparisons between malignant and benign indications are limited. In addition, Ten additional questions pertaining to physical wellbeing were answered on a "yes" or "no" format, or a quantity was specified.…”