Quality of life in women with endometriosis: a narrative overview

Rosa, Valentina Lucia La; Franciscis, Pasquale De; Barra, Fabio; Schiattarella, Antonio; Török, Péter; Shah, Mohsin; Karaman, Erbil; Cerentini, Taís Marques; Guardo, Federica Di; Gullo, Giuseppe; Ponta, Marco; Ferrero, Simone

doi:10.23736/s0026-4806.19.06298-0

Cited by 55 publications

(48 citation statements)

References 96 publications

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“…Lesions may deeply infiltrate local tissues or may have a superficial presentation. The inconsistent demonstration of the disease is associated with a wide range of accompanying symptoms that affect the quality of life and psychological prosperity of the affected women [ 4 , 5 ]. The symptoms are mainly divided into two groups: Those associated with pain and those related to sub- or infertility [ 3 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

CD200 and CD200R Expression on Peripheral Blood Lymphocytes and Serum CD200 Concentration as a New Marker of Endometriosis

Abramiuk

Grywalska

Korona-Głowniak

et al. 2020

JCM

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The causes of endometriosis (EMS) remain unknown; however, a number of immunological abnormalities contribute to the pathogenesis of the disease. The cluster of differentiation-200 (CD200) and its receptor (CD200R) maintain peripheral self-tolerance by negatively regulating immune responses. In this comparative cross-sectional study, we investigated the expression of CD200 and CD200R on T and B lymphocytes and the serum level of soluble CD200 (sCD200) using flow cytometry and ELISA, respectively. Peripheral blood samples were collected from 54 female patients and 20 healthy, age-matched controls. Results were tested for correlation with disease severity and selected clinical parameters. We demonstrated that the differences in sCD200 levels (p = 0.001), the frequencies of CD200-positive T and B lymphocytes (p < 0.001 and p = 0.004, respectively), and the frequencies of CD200R-positive T and B lymphocytes (p < 0.001 for all comparisons) in the study group correlated positively with disease severity. Receiver operating characteristic (ROC) analysis indicated that aberrant expression of CD200/CD200R might serve as a marker to distinguish between EMS cases. Finally, negative co-stimulatory factors may contribute to the induction and persistence of inflammation associated with EMS. It seems that it is essential to determine whether alteration in the CD200/CD200R pathway can be therapeutically targeted in EMS.

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Section: Introductionmentioning

confidence: 99%

CD200 and CD200R Expression on Peripheral Blood Lymphocytes and Serum CD200 Concentration as a New Marker of Endometriosis

Abramiuk

Grywalska

Korona-Głowniak

et al. 2020

JCM

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“…What are the clinical implications of these findings? In previous study, the effects of endometriosis, a characteristic symptom of menstrual pain, on psychological, social factors and quality of life have already been identified [27,28]. In a future study, it could be possible to further study the effect of knowledge and perception of menstruation and menstrual products on the psychological, social factors and behavior changes of women experiencing dysmenorrhea.…”

Section: Discussionmentioning

confidence: 94%

How can we improve knowledge and perceptions of menstruation? A mixed-methods research study

Moon

Kim

et al. 2020

BMC Women's Health

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Background Traditionally, menstrual education has consisted of lectures directed toward women. The objective of this study was to design an innovative menstrual education (ME) program that reflects the needs of both young women and men, and verify its effectiveness. Methods A mixed-method design was used to determine the program needs and assess young adults’ knowledge and perceptions of menstruation and menstrual products. Focus group interviews were conducted with 14 young adults, and 150 young adults participated in an online survey. After developing the ME program, 10 young adults participated in a study to verify its effectiveness. Results Interview results showed young adults wanted more information about menstrual products. The online survey revealed significant differences in knowledge based on participants’ general characteristics and experience; exposure to menstruation and menstrual products positively impacted knowledge and perception. In addition, the results indicated young adults wanted ME content access via mobile and in-person modalities, designed for both genders, drawing on menstrual experts’ knowledge. Based on these results, a multi-experimental menstrual education (MEME) program was designed and included: hands-on exposure to 60 menstrual products, product demonstrations with a female perineal model, a YouTube video created by the researchers, a true-or-false quiz, and question-and-answer sessions with menstrual experts. Conclusions This study clarified the requirements of an innovative menstrual education program. It led to high satisfaction among participants, and improved knowledge and perceptions of menstruation and menstrual products. The online survey showed a correlation between the extent of received ME, and respondents’ perception of menstrual products. This implied that a MEME program could change perceptions when conducted systematically; by extension it could ameliorate menstruation challenges attributed to poverty. Future research could further verify the effectiveness of the MEME program, using a larger sample, and examine its suitability for incorporation into official ME curricula at universities and companies. Trial registration This trial was registered in a Clinical Research Information Service in Korea linked with the World Health Organization’s International Clinical Trial Registry Platform (WHO’s ICTRP) (no. KCT0004715), Registered 07 Feb 2020.

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“…As an obvious consequence, important social and healthcare direct and indirect costs should be also considered and possibly avoided. For the correct management of both pathology and quality of life, we retain that a holistic approach could be of clinical importance and should include regular follow-up of the mental and physical status of affected women and also advices on the adoption of adapta-DOI: 10.1159/000508225 tive/constructive coping strategies (physical fitness, rest, yoga, equilibrate diets, massage, acupuncture, warm baths, or heating pads) to better handle the pain, improve overall sexual functioning, and restore own self-appraisal [31][32][33].…”

Section: Discussion/conclusionmentioning

confidence: 99%

The Many Faces of Endometriosis-Related Neoplasms in the Same Patient: A Brief Report

Santoro

Angelico

Inzani

et al. 2020

Gynecol Obstet Invest

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• Endometriosis is the land for any histological type of tumor found in the endometrium with a malignant transformation rate variable from 0.7 to 1.6%. • Recently, sequencing studies have clearly defined a clonal relationship between endometriosis and its malignant counterparts, confirming that the cancers can arise from the adjacent endometriotic focus. Novel Insights • This case represents the first evidence in the literature of the simultaneous occurrence of clear-cell ovarian carcinoma (CCC) and low-grade uterine-extrauterine endometrial stromal sarcoma (LG-ESS) arising in the background of ovarian and pelvic endometriosis. • The present case, staged as FIGO IC for the ovarian neoplasm and IIIA for the LG-ESS, represents a clinical and pathological challenge, especially in terms of surgical staging and patient management.

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Quality of life in women with endometriosis: a narrative overview

Cited by 55 publications

References 96 publications

CD200 and CD200R Expression on Peripheral Blood Lymphocytes and Serum CD200 Concentration as a New Marker of Endometriosis

CD200 and CD200R Expression on Peripheral Blood Lymphocytes and Serum CD200 Concentration as a New Marker of Endometriosis

How can we improve knowledge and perceptions of menstruation? A mixed-methods research study

The Many Faces of Endometriosis-Related Neoplasms in the Same Patient: A Brief Report

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