Quality of life in unaffected twins discordant for affective disorder

Vinberg, Maj; Bech, Per; Kyvik, Kirsten Ohm; Kessing, Lars Vedel

doi:10.1016/j.jad.2006.08.033

“…Consistent with previous studies, our results show that MDD and disposition to LS are moderately inversely related ( r p = −0.36), indicating that the two phenotypes belong to separable, but correlated dimensions. In accordance with the results from the three previous studies, exploring related phenotypes (Kendler et al, 2011b, Nes et al, 2008, Vinberg et al, 2007), our findings show a substantial, but far from complete overlap in genetic risk factors ( r a = −0.55). Thus, a disposition to life satisfaction does not merely constitute the “other end” of the genetic liability to depression.…”

Section: Discussionsupporting

confidence: 92%

“…Vinberg and colleagues examined quality of life in first-degree relatives of probands with affective disorder, finding quality of life to be impaired in twins with an affected co-twin, and suggesting a common familial vulnerability with affective disorders (Vinberg et al, 2007). Nes and colleagues (Nes et al, 2008) explored etiological factors explaining associations between LS and self-report symptoms of anxiety and depression, using a single-item LS measure and a short-form of the Hopkins Symptom Checklist (Tambs and Moum, 1993).…”

Section: Introductionmentioning

confidence: 99%

Major depression and life satisfaction: A population-based twin study

Nes

¹

,

Czajkowski

²

,

Røysamb

³

et al. 2013

Journal of Affective Disorders

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Background The extent to which positive and negative indicators of mental health share etiological influences has been studied to a limited degree only. This study examines the genetic and environmental influences on association between liability to lifetime DSM-IV Major Depressive Disorder (MDD) and dispositional life satisfaction (LS). Methods Two-wave questionnaire data on LS (assessed 6 years apart) and lifetime MDD obtained by structured clinical interviews in a population-based sample of adult twins were analysed using structural equation modelling in Mx. Results The prevalence of lifetime MDD was estimated to be 11.1% and 15.8% in males and females, respectively. Individuals fulfilling the criteria for MDD reported significantly lower levels of LS. The co-variation in MDD and dispositional LS was found to be accounted for by genetic and unique environmental influences only. The phenotypic correlation was estimated to be 0.36, of which genetic influences accounted for 74% and environmental factors the remaining 26%. The correlation between genetic factors for MDD and LS was estimated to be −0.55 and the correlation between unique environmental factors to be −0.22. Heritability was estimated to 0.34 and 0.72 for MDD and LS, respectively. Limitations The sample consists of twins only and there are limitations associated with the twin design. Conclusions Whereas genetic influences on vulnerability to lifetime MDD are considerably shared with liability to (low) LS, environmental influences are more distinct. Thus, environmental factors associated with risk of MDD do not strongly impact on dispositional LS, and conversely, environmental factors influencing dispositional LS do not strongly buffer against MDD.

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“…For example, related physical phenotypes include metabolic efficiency (Gottfredson, 2004), disease severity, maximal walking speed and exercise behavior (de Moor, 2007). Related psychological attributes were found to encompass, for example, adaptation to stressful environments (Gottfredson, 2004), resilience to stressful situations (Curtis et al, 2003), perceived sense of control (Johnson, 2005a; 2005b), intelligence (Gottfredson, 2004), affective disorders (Vinberg et al, 2007), and depressive symptoms (Leinonen et al, 2005). …”

Section: The Geneqol Consortiummentioning

confidence: 99%

The Establishment of the GENEQOL Consortium to Investigate the Genetic Disposition of Patient-Reported Quality-of-Life Outcomes

Sprangers¹,

Sloan

²

,

Veenhoven

³

et al. 2009

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T o our knowledge, no comprehensive, interdisciplinary initiatives have been taken to examine the role of genetic variants on patient-reported qualityof-life outcomes. The overall objective of this paper is to describe the establishment of an international and interdisciplinary consortium, the GENEQOL Consortium, which intends to investigate the genetic disposition of patient-reported quality-of-life outcomes. We have identified five primary patientreported quality-of-life outcomes as initial targets: negative psychological affect, positive psychological affect, self-rated physical health, pain, and fatigue. The first tangible objective of the GENEQOL Consortium is to develop a list of potential biological pathways, genes and genetic variants involved in these quality-of-life outcomes, by reviewing current genetic knowledge. The second objective is to design a research agenda to investigate and validate those genes and genetic variants of patient-reported quality-of-life outcomes, by creating large datasets. During its first meeting, the Consortium has discussed draft summary documents addressing these questions for each patient-reported quality-of-life outcome. A summary of the primary pathways and robust findings of the genetic variants involved is presented here. The research agenda outlines possible research objectives and approaches to examine these and new quality-of-life domains. Intriguing questions arising from this endeavor are discussed.

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The Establishment of the GENEQOL Consortium to Investigate the Genetic Disposition of Patient-Reported Quality-of-Life Outcomes

Sprangers¹,

Sloan²,

Veenhoven³

et al. 2009

View full text Add to dashboard Cite

T o our knowledge, no comprehensive, interdisciplinary initiatives have been taken to examine the role of genetic variants on patient-reported qualityof-life outcomes. The overall objective of this paper is to describe the establishment of an international and interdisciplinary consortium, the GENEQOL Consortium, which intends to investigate the genetic disposition of patient-reported quality-of-life outcomes. We have identified five primary patientreported quality-of-life outcomes as initial targets: negative psychological affect, positive psychological affect, self-rated physical health, pain, and fatigue. The first tangible objective of the GENEQOL Consortium is to develop a list of potential biological pathways, genes and genetic variants involved in these quality-of-life outcomes, by reviewing current genetic knowledge. The second objective is to design a research agenda to investigate and validate those genes and genetic variants of patient-reported quality-of-life outcomes, by creating large datasets. During its first meeting, the Consortium has discussed draft summary documents addressing these questions for each patient-reported quality-of-life outcome. A summary of the primary pathways and robust findings of the genetic variants involved is presented here. The research agenda outlines possible research objectives and approaches to examine these and new quality-of-life domains. Intriguing questions arising from this endeavor are discussed.

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Quality of life in unaffected twins discordant for affective disorder

Cited by 4 publications

References 17 publications

Major depression and life satisfaction: A population-based twin study

Major depression and life satisfaction: A population-based twin study

The Establishment of the GENEQOL Consortium to Investigate the Genetic Disposition of Patient-Reported Quality-of-Life Outcomes

The Establishment of the GENEQOL Consortium to Investigate the Genetic Disposition of Patient-Reported Quality-of-Life Outcomes

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