Quality of life in the year after new diagnosis with advanced prostate cancer for Black and White individuals living in the US

Pain and Its Association with Survival for Black and White Individuals with Advanced Prostate Cancer in the United States

“…In our study population, Black participants reported more pain than White participants across all four pain scales at study enrollment. Though not described in this study, our group previously explored longitudinal pain in this population, finding that pain increased over the first year of follow-up similarly for both Black and White participants ( 10 ). As race is a social construct, we believe that the racial disparities we see in pain in our study are a result of structural racism and social determinants of health impacting the experience, reporting, and management of pain.…”

“…For the models representing the longitudinal trajectories of pain, we fit linear mixed effects models for the pain scales with month of questionnaire as linear, quadratic, and cubic terms and with observations clustered within study participants. While we do not explicitly model the trajectories of pain in this study, our group has previously modeled the longitudinal trajectory of the EORTC pain scale in this cohort over the first year of follow-up ( 10 ).…”

“…Previous studies have shown that Black individuals with advanced prostate cancer report more severe bone pain than White individuals ( 8, 9 ). In addition, our group has previously shown that Black participants in the International Registry for Men with Advanced Prostate Cancer (IRONMAN) registry reported worse pain overall at study enrollment compared with White participants, and that pain increased throughout the first year of follow-up similarly for both racial groups ( 10 ). While these differences in bone and overall pain by race are known, it is not clear whether various aspects of pain (severity, duration, interference with daily activities, etc.)…”

Integrated metabolic profiles and microbial communities to reveal the beneficial effect of red pitaya on early constipation

“…Constipation is a prevalent condition that has a substantial impact on the quality of life and can worsen the course of other diseases in individuals with compromised physiological functions. 24 Constipation is defined as when the frequency of defecation is largely reduced, the stool is dry and hard, and it is difficult to defecate. The latest data indicate that the incidence of constipation in Chinese adults is 7–20.3%, with a notably higher prevalence observed in women compared to men, and the incidence increases with age.…”