Quality of life in survivors of childhood brain tumour and the association of children's diseases on quality of their parents life

Abstract

Objective: Evaluation of children's quality of life (QoL) after finished brain tumour treatment and the association of children's diseases on quality of their parents' life.Methods: The study group was consisted of 46 children after brain tumour treatment (aged 4, 5, to 29 years old). The control group was composed of 104 students of primary, secondary, and high schools. One hundred fifty (104 + 46) parents were included in the study. Standardised QoL questionnaires (PEDsQL-4.0, WHOQOL-BREF) were used. Survivors' QoL was assessed from patients' and their parents' point of view, also the association of children's diseases on quality of their parents' life was estimated.Results: QoL of children after brain tumour treatment was lower than in the control group according to the children (P < 0.001) and their parents (P < 0.001). The survivors worst rated their ability to social functioning (P < 0.0010) and physical functioning (P < 0.001) in comparison with self-assessment of healthy children. According to their parents, the functioning of children in all zones was worse than in the control group, mostly in social (P < 0.001) and physical sphere (P < 0.001), too. QoL of children with low-grade tumour was comparable with QoL of children with high-grade tumour).QoL of survivors' caregivers in study was higher than QoL of parents of control groups (P = 0.023). Conclusions:The quality of patients' life after brain tumour treatment is lower in comparison with healthy children. QoL of the parents of survivor is higher than the QoL of healthy children parents. The assessment of QoL of children after brain tumour treatment should be an inherent element of health monitoring. KEYWORDS brain tumour, children, cancer, oncology, quality of life 1 | BACKGROUND Central nervous system (CNS) tumours are the second most common group of cancers in children, accounting for a more than quarter (26%) of all childhood cancers. 1 Their reported incidence has been increasing over the past 30 years, probably due to improved diagnostics. Composed anticancer therapy usually involves at least one of three main modalities: localised surgical resection, radiotherapy, and/or chemotherapy. 2 Refinements in imaging, surgical technique, and adjunctive therapies have led to longer survival in children with CNS tumours. 3 Over the years, a 5-year survival rate for childhood CNS tumours increased, currently up to 72% owing to the introduction and ongoing modification of powerful treatment protocols. 4Aggressive treatment is often essential to cure this potentially lethal

Can We Compare the Health-Related Quality of Life of Childhood Cancer Survivors Following Photon and Proton Radiation Therapy? A Systematic Review

“…A total of 14 studies are cross-sectional, 15 studies are longitudinal, and 1 study uses both longitudinal and cross-sectional data collection. Articles are included from the United States [ 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ], Switzerland [ 30 , 31 , 32 , 33 ], South Korea [ 34 , 35 ], Canada [ 36 , 37 ], Japan [ 38 , 39 ], Netherlands [ 40 , 41 ], India [ 42 ], United Kingdom [ 43 , 44 ], Germany [ 45 ], Brazil [ 46 ], Italy [ 47 ], Poland [ 48 ], North American collaboration [ 49 ], European collaboration, [ 50 ] and an international collaborative [ 51 ].…”

“…No effect is observed between SES and HRQoL, however variable methods of determining SES are used, and there is low representation of families within the low SES categories. Five studies find no statistically significant differences by sex in patients who undergo RT [ 22 , 24 , 26 , 43 , 48 ]. Three studies find no correlation between age and HRQoL [ 22 , 24 , 43 ], while Musiol et al (2019) describe a weak negative correlation between age at diagnosis and self-reported emotional functioning [ 48 ].…”

“…Five studies find no statistically significant differences by sex in patients who undergo RT [ 22 , 24 , 26 , 43 , 48 ]. Three studies find no correlation between age and HRQoL [ 22 , 24 , 43 ], while Musiol et al (2019) describe a weak negative correlation between age at diagnosis and self-reported emotional functioning [ 48 ]. Three studies analyse the impact of race, however there is limited representation of non-white participants that hinders producing a true analysis [ 22 , 24 , 26 ].…”

“…Three studies found that the self-reported HRQoL is worse for patients with brain tumours requiring RT than patients not requiring RT [ 36 , 43 , 45 ]. Musiol et al (2019) report that the overall self-reported HRQoL in survivors treated with both RT and chemotherapy is comparable with that of survivors treated only with chemotherapy [ 48 ].…”

La resiliencia de los padres de niños con cáncer y su importancia en el manejo del estrés y la satisfacción vital

“…Además, es un constructo multidimensional que está conformado por diferentes dimensiones, familia, trabajo, salud, etc. La vivencia del cáncer tiene importantes repercusiones sobre la satisfacción vital de los padres (16) . En este sentido, la calidad de vida de los padres de niños con cáncer se ve afectada de manera negativa por la enfermedad oncológica (17) .…”