Quality of Life in Spinal Cord Injury Patients with Urinary Difficulties

Costa, P.; Perrouin-Verbe, B.; Colvez, Alain; Jp, Didier; Marquis, Patrick; Marrel, Alexia; Amarenco, G.; Espirac, Brigitte; Leriche, A.

doi:10.1159/000052421

Cited by 173 publications

(155 citation statements)

References 23 publications

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“…Fourteen Level one studies reporting on 13 QOL instruments have been investigated with SCI populations: eight objective instruments, including the Patient Reported Impact of Spasticity Measure (PRISM), 22 the Quality of Well-being Scale (QWB), 6 the Qualiveen, 23 the Sickness Impact Profile (SIP68), 27 Table 4. Validity data is presented in Tables 5 and 6.…”

Section: Resultsmentioning

confidence: 99%

“…1,6,9,20,21 Where no distinction was specified, instruments were classified according to the authors' definition of QOL 7 and/or the item content and scoring model. 22,23 For example, instruments addressing HRQOL or the presence, severity, and impact of specific health factors relating to QOL were considered objective, and instruments measuring life satisfaction or using scoring relationships between satisfaction and importance were classified as subjective. Table 1 provides a description of the evaluation criteria.…”

Section: Classifying the Instrumentsmentioning

confidence: 99%

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Quality of life instruments and definitions in individuals with spinal cord injury: a systematic review

et al. 2009

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Section: Resultsmentioning

confidence: 99%

Section: Classifying the Instrumentsmentioning

confidence: 99%

Quality of life instruments and definitions in individuals with spinal cord injury: a systematic review

et al. 2009

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“…IMPROVED BLADDER CONTROL IS an unmet need in persons with urinary incontinence (1) and in persons with neurological disease or injury, such as spinal cord injury (9). Electrical stimulation is a promising approach to treat overactive bladder (OAB), which can produce urgency and incontinence and impair quality of life (8,32).…”

mentioning

confidence: 99%

A spinal GABAergic mechanism is necessary for bladder inhibition by pudendal afferent stimulation

McGee

Danziger

Bamford

et al. 2014

American Journal of Physiology-Renal Physiology

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McGee MJ, Danziger ZC, Bamford JA, Grill WM. A spinal GABAergic mechanism is necessary for bladder inhibition by pudendal afferent stimulation. Am J Physiol Renal Physiol 307: F921-F930, 2014. First published August 20, 2014 doi:10.1152/ajprenal.00330.2014.-Electrical stimulation of pudendal afferents can inhibit bladder contractions and increase bladder capacity. Recent results suggest that stimulation-evoked bladder inhibition is mediated by a mechanism other than activation of sympathetic bladder efferents in the hypogastric nerve, generating ␣-adrenergic receptor-mediated inhibition at the vesical ganglia and/or ␤-adrenergic receptor-mediated direct inhibition of the detrusor muscle. We investigated several inhibitory neurotransmitters that may instead be necessary for stimulation-evoked inhibition and found that intravenous picrotoxin, a noncompetitive GABAA antagonist, significantly and reversibly blocked pudendal afferent stimulation-evoked inhibition of bladder contractions in a dose-dependent manner. Similarly, intravenous picrotoxin also blocked pudendal afferent stimulation-evoked inhibition of nociceptive bladder contractions evoked by acetic acid infusion. Furthermore, intrathecal administration of picrotoxin at the lumbosacral spinal cord also blocked bladder inhibition by pudendal afferent stimulation. On the other hand, glycinergic, adrenergic, or opioidergic mechanisms were not necessary for bladder inhibition evoked by pudendal afferent stimulation. These results identify a lumbosacral spinal GABAergic mechanism of bladder inhibition evoked by pudendal afferent stimulation. electrical stimulation; bladder inhibition; pudendal nerve; dorsal nerve of the penis; GABA; picrotoxin IMPROVED BLADDER CONTROL IS an unmet need in persons with urinary incontinence (1) and in persons with neurological disease or injury, such as spinal cord injury (9). Electrical stimulation is a promising approach to treat overactive bladder (OAB), which can produce urgency and incontinence and impair quality of life (8, 32). In particular, pudendal afferent stimulation inhibits distension-evoked bladder contractions and improves continence (51). We sought to identify the mechanism(s) of bladder inhibition by pudendal afferent stimulation.Pudendal nerve (PN) stimulation may be an alternative to sacral nerve stimulation to improve continence (33), and in patients who do not respond to sacral neuromodulation it may be a successful treatment option (29,34,41). Low-frequency (ϳ10 Hz) pudendal afferent stimulation inhibits bladder contractions, thereby promoting continence in preclinical animal studies (4, 46, 52). Inhibition of bladder contractions and increased bladder capacities elicited by low-frequency pudendal afferent stimulation can also be achieved after chronic spinal cord injury (43, 47). However, the mechanisms of action of PN stimulation-mediated bladder inhibition are unclear, and such knowledge may improve patient selection and enable improvements in therapy.Initial studies suggested that pudendal afferent stimu...

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“…Therefore, we concluded that the I-QOL is a validated scale for patients with MS. Inclusion of a relatively homogenous group (the majority of patients had a low EDSS score [0][1][2][3][4] and all patients in the study group consisted of patients with MS) and the large number of patients with MS may be considered strengths of our study. However, the generalizability of these results may be limited and may not reflect a naturalistic setting.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, it is important to investigate this complaint and start appropriate treatment early. Different scales (International Consultation on Incontinence Questionnaire Short Form, Qualiveen) are used in the evaluation of incontinence in patients with MS [3][4]. The Incontinence Quality of Life Scale (I-QOL) is a questionnaire used to evaluate the effect of incontinence on QOL.…”

Section: Introductionmentioning

confidence: 99%

Quality of life in patients with multiple sclerosis and urinary disorders: Reliability and validity of Turkish-language version of Incontinence Quality of Life Scale

Eyigör

Karapolat²,

Akkoç³

et al. 2010

JRRD

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Abstract-Incontinence is one of the most frequently encountered problems in multiple sclerosis (MS), and it has a negative effect on the daily lives of patients. Therefore, it is important to investigate this complaint and start appropriate treatment early. The aim of our study was to demonstrate the validity and reliability of the Turkish-language Incontinence Quality of Life Scale (I-QOL) in patients with MS. We included 37 patients with MS in this study. For analysis of test-retest reliability, we administered the Turkish-language version of I-QOL developed by a "translation-back translation" method to patients on the day of admission and 1 week after admission. To assess validity, we also evaluated patients with the Multiple Sclerosis Quality of Life Scale (MQOL-54) and Expanded Disability Status Scale (EDSS). We calculated the intraclass correlation coefficient of the I-QOL (total and all subscores) as 0.88 to 0.91 and the Cronbach alpha score as 0.88 to 0.91 (p < 0.05). We found a significant correlation among all subscores of I-QOL and physical and mental subscores of MQOL-54 and EDSS (p < 0.05). Our study has demonstrated the internal consistency and reliability of the I-QOL in the Turkish language in patients with MS.

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Quality of Life in Spinal Cord Injury Patients with Urinary Difficulties

Cited by 173 publications

References 23 publications

Quality of life instruments and definitions in individuals with spinal cord injury: a systematic review

Quality of life instruments and definitions in individuals with spinal cord injury: a systematic review

A spinal GABAergic mechanism is necessary for bladder inhibition by pudendal afferent stimulation

Quality of life in patients with multiple sclerosis and urinary disorders: Reliability and validity of Turkish-language version of Incontinence Quality of Life Scale

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