Quality of life in patients with cervical cancer FIGO IIb stage after concomitant chemoradiotherapy

Ljuca, Dženita; Marosevic, Goran

doi:10.2478/v10019-009-0025-9

Cited by 16 publications

(15 citation statements)

References 10 publications

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“…On the other hand, there was worsening of financial difficulties after treatment and all of these were statistically significant. Similar results were obtained by Lachi et al and Ljuca et al 11,12 The study of Fang et al concluded that patient-reported health related QoL significantly worsened during radiotherapy treatment with subsequent improvement, affirming transiency of treatment-induced toxicities. 13 In the present study it was found that during follow up, none were sexually active after treatment.…”

Section: Discussionsupporting

confidence: 77%

Effect of treatment on the quality of life of cervical cancer patients: a prospective study from a tertiary care centre of West Bengal

Sarkar

2019

Int J Community Med Public Health

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Background: Cervical cancer is one of many health care ironies. Better survival rates demand better quality of life (QoL). The aim of present study was to determine the change in QoL of cervical cancer patients due to treatment.Methods: An observational prospective study was conducted from July 2017 to June 2018 among 80 new cervical cancer patients without any prior history of treatment for cervical cancer, attending radiotherapy department of a tertiary care centre of West Bengal using a semi-structured schedule and European Organization for Research and Treatment of Cancer (EORTC) quality of life questionnaire (QLQ). Information was collected on socio-demographic and clinical aspects and QoL domains. Those with history of surgery for cervical cancer, advanced stage of disease were excluded. EORTC QLQ was administered at baseline and one month after completion of treatment. Data was analysed by percentage, means±standard deviation, range and Wilcoxon signed rank test etc. using SPSS-16.Results: Only 60 patients could be analysed as 10 patients died and 10 lost to follow-up. After treatment there was a significant improvement in global health, physical, emotional and cognitive functioning as well as decrease in symptoms like fatigue, pain, insomnia, appetite loss and constipation along with worsening of financial difficulties. There was significant improvement in body image, decrease in problems of symptom experience, peripheral neuropathy and menopausal symptoms after treatment.Conclusions: The cervical cancer patients show an overall improvement in their QoL in most of the domains after one month of treatment except worsening of financial difficulties.

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Section: Discussionsupporting

confidence: 77%

Effect of treatment on the quality of life of cervical cancer patients: a prospective study from a tertiary care centre of West Bengal

Sarkar

2019

Int J Community Med Public Health

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“…Treatment modality also affects the QOL, Women who receive combined treatment of cervical cancer by surgery and radiotherapy suffers from urinary incontinence which limit the patient activity, comfort and quality of life. 8 Now a day, interest in investigation of the QOL in different diseases are increasing due to its potential value in identifying patient's problems and discovering the challenges and planning for the health system. 9 Due to long term survival of cervical cancer patient's as a result of screening methods and its early treatment, study in the field of QOL and its related factors are important to improve the QOL among cervical cancer survivor.…”

Section: Introductionmentioning

confidence: 99%

Quality of life of cervical cancer patients after completion of treatment -A study among Bangladeshi women

Hossain

Akter

Banu

et al. 2016

Bangladesh Med Res Counc Bull

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Cervical cancer is the main cause of malignancy-related death among women living in developing countries. The aim of this study is to evaluate the quality of life (QOL) among Bangladeshi cervical cancer survivors and its relationships with demographic and disease related factors A cross-sectional study was carried out on one hundred nine consecutive cervical cancer survivors in National Institute of cancer Research and Hospital, Dhaka from September 2014 to february2015 using European organization for Research and treatment of cancer core Questionnaires (QOL-C30 and QOL-CX24). Demographic condition like education level, occupation and disease related factors like stages, treatment modality and duration of follow-up time were taken as investigating factors against functional scales. Cronbach´s alpha was calculated to asses' internal consistency among items.Cervical cancer survivors stated a moderate QOL. Sub-domains of QOL score and global health status were significantly associated with physical function(PF) scales (p=.000), fatigue (p=.045), nausea and vomiting (p=.000), Appetite loss (p=.001), constipation (p=.005), symptom experience (p=.005) and menopausal symptoms (p=.015). QOL mean score were negatively associated with emotional function(EF) scales, pain, fatigue, nausea, appetite loss and financial problems. Education level showed significant association with physical function(PF) (p=.001), emotional function(EF) (p=.027), Cognitive function(CF) (p=.000) and sexual function (p=.001). Duration (Follow-up) time was significance association with PF (p=.005), EF (p=.012), symptoms experience (p=.001). Although, the QOL in cervical cancer survivors was moderate, treatment of related symptoms and improvement of demographic condition can influence the QOL and survivors improve the care of cervical cancer. So, improve the QOL among cervical cancer survivors.

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“…Nonetheless, by investigating several complication endpoints via an analysis of many patient and treatment factors, our experience will be helpful to those institutions where HDRICB is performed. In the future, monitoring the information of quality of life before and after CCRT would be essential to clarify the benefit of IMRT 23. Although we failed to demonstrate the robust advantage of IMRT in definitive CCRT for advanced cervical cancer, the result will also help where the cost-effectiveness of IMRT is a concern, particularly when the resources are limited.…”

Section: Discussionmentioning

confidence: 80%

Does initial 45Gy of pelvic intensity-modulated radiotherapy reduce late complications in patients with locally advanced cervical cancer? A cohort control study using definitive chemoradiotherapy with high-dose rate brachytherapy

Chen¹,

Liang²,

Yeh³

et al. 2013

Radiology and Oncology

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BackgroundComparing initial 45 Gy of pelvic intensity-modulated radiation therapy (IMRT) and non-IMRT in terms of the late toxicities associated with advanced cervical cancer that has also been treated with definitive concurrent chemoradiotherapy and high-dose rate intracavitary brachytherapy (HDRICB).Patients and methods This retrospective study included 320 stage IB2-IIIB cervical cancer patients treated with CCRT (83 IMRT and 237 non-IMRT). The two groups had similar stage and HDRICB ratings. Following 45 Gy to the pelvis, HDRICB of 24 Gy in four courses was prescribed. Late toxicities, including rectal complications (RC), bladder complications (BC) and non-rectal intestinal injury (NRRII), were scored by the Common Terminology Criteria for Adverse Events. A logistic regression was used to estimate the odds ratio (OR) of the complications.ResultsWith a median follow-up duration of 33 and 77 months for IMRT and non-IMRT, 33 patients had Grade 2 or higher late RC (7.2% IMRT, 11.4% non-IMRT), whereas that for BC was 40 (9.6% IMRT, 13.5% non-IMRT) and for NRRII was 48 (12.0% IMRT, 16.0% non-IMRT). The cumulative rate for total grade 3 or higher gastrointestinal or genitourinary toxicities was 8.4% and 11.8% (p = 0.33). IMRT did not reduce the OR for all endpoints; however, the ORs for rectum and bladder reference doses to Point A were associated with RC and BC.ConclusionsLocally advanced cervical cancer patients treated with initial 45Gy of pelvic IMRT and HDRICB have similar treatment-related late toxicities as those treated with non-IMRT. Optimization of the brachytherapy scheme is essential to minimize late toxicities.

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Quality of life in patients with cervical cancer FIGO IIb stage after concomitant chemoradiotherapy

Cited by 16 publications

References 10 publications

Effect of treatment on the quality of life of cervical cancer patients: a prospective study from a tertiary care centre of West Bengal

Effect of treatment on the quality of life of cervical cancer patients: a prospective study from a tertiary care centre of West Bengal

Quality of life of cervical cancer patients after completion of treatment -A study among Bangladeshi women

Does initial 45Gy of pelvic intensity-modulated radiotherapy reduce late complications in patients with locally advanced cervical cancer? A cohort control study using definitive chemoradiotherapy with high-dose rate brachytherapy

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