Quality of life in patients with nonalcoholic fatty liver disease: A systematic review

Assimakopoulos, Konstantinos; Karaivazoglou, Katerina; Tsermpini, Evangelia‐Eirini; Διαμαντοπούλου, Γεωργία; Triantos, Christos

doi:10.1016/j.jpsychores.2018.07.004

Cited by 37 publications

(34 citation statements)

References 28 publications

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“…This finding coincides with the study by David et al (13), as it confirms the significant effect of fibrosis on QoL. In agreement with previous studies, the impact on QoL was mainly physical (3)(4)(5)(6). Patients with significant fibrosis had particularly more impairment in physical functioning, rolephysical, PCS, activity, emotional, fatigue, systemic symptoms, worry, and total CLDQ-NAFLD.…”

Section: Discussionsupporting

confidence: 92%

“…Non-alcoholic fatty liver disease (NAFLD) causes a stronger negative impact on patients' quality of life (QoL) than do viral, alcoholic, autoimmune, or cholestatic liver diseases (1,2), especially impairing physical functioning or the ability to perform daily activities (3)(4)(5)(6). Mental health is also affected by an increase in anxiety and depressive symptoms (7).…”

Section: Introductionmentioning

confidence: 99%

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Psychological Biomarkers and Fibrosis: An Innovative Approach to Non-alcoholic Fatty Liver Disease

et al. 2020

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Background: It is unknown how perceived social support and the progression of liver damage influence the psychosocial profile of patients with non-alcoholic fatty liver disease (NAFLD). In the present study, we therefore investigated which biomarkers influence the quality of life, mental health, and coping strategies of NAFLD patients. Methods: Quality of life (SF-12 and CLDQ-NAFLD), mental health (HADS and BDI-II), and coping strategies (COPE-28) were evaluated by high or low perceived social support (MSPSS) and the presence of non-alcoholic steatohepatitis (NASH) and significant fibrosis in 492 biopsy-proven NAFLD patients. The results were compared with quality of life normality tables for the general Spanish population. We also determined whether liver histology and biopsychosocial variables predicted participants' quality of life. Results: Interactive effects were found in vitality (p = 0.05), activity (p = 0.005), anxiety (p = 0.04), and denial (p = 0.04), with NASH patients showing a higher-risk biopsychosocial profile when they perceived less social support. Furthermore, patients with low perceived social support showed lower quality of life, worse mental health, and more maladaptive coping than those with high perceived social support, regardless of NASH presence. Patients with significant fibrosis showed lower quality of life compared to those without or the general Spanish population. Patients with significant fibrosis also reported worse mental health and more maladaptive coping. Lastly, significant fibrosis, female sex, greater anxiety and depressive symptoms, and worse physical and mental health-related quality of life were found to be independent determinants of worse disease-specific quality of life in these patients. Conclusions: Low perceived social support, significant fibrosis, and female sex were independently associated with a higher-risk psychosocial profile in NAFLD. These findings support the role of psychological biomarkers based on quality of life, mental health, and coping strategies in the management of these patients and suggest the potential benefits of a psychological intervention.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Psychological Biomarkers and Fibrosis: An Innovative Approach to Non-alcoholic Fatty Liver Disease

et al. 2020

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“…Therefore, this provides a good basis for investigating the potential link between NAFLD and health-related quality of life (HRQoL). Several studies report that patients with NAFLD score low on the quality of life assessment tool, in terms of physical, emotional, and economical assessments [ 24 , 25 , 26 , 27 ]. The EuroQol- 5D (EQ-5D), developed in Europe, has proven useful as an HRQoL assessment tool in many studies [ 28 , 29 , 30 , 31 ], including those involving Koreans [ 32 , 33 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

Association between Non-Alcoholic Fatty Liver Disease and Dietary Habits, Stress, and Health-Related Quality of Life in Korean Adults

Han¹

2020

Nutrients

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Considering the increasing prevalence of non-alcoholic fatty liver disease (NAFLD), this study aimed to evaluate the association between NAFLD and dietary habits, stress, and health-related quality of life (HRQoL) in Korean individuals by using data from the Korea National Health and Nutrition Examination Survey (KNHANES) VI 2013–2015. NAFLD was defined in individuals with a hepatic steatosis index (HSI) value ≥36. Eating habits were assessed based on the frequencies of eating and eating out; stress was assessed through the stress perception rate; and the EuroQol-5D (EQ-5D) questionnaire was used to assess the HRQoL. We performed a complex sample logistic regression analysis and estimated the odds ratios by adjusting for significant factors to evaluate associations between NAFLD and dietary habits, stress, and HRQoL. Occurrence of NAFLD was not significantly associated with meal frequencies over one week. With an increase in stress, based on the stress perception rate, the risk of NAFLD increased 1.316-fold (95% confidence interval (CI): 1.175–1.469, p < 0.05). Additionally, a decrease in the EQ-5D score by 1 increased the risk of NAFLD 3.38-fold (95% CI: 1.893–4.844, p < 0.05). Thus, NAFLD treatment should include stress management, and underlying HRQoL should be considered during treatment.

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“…The treatment plan of NAFLD should incorporate strategies to improve the physical and psychological aspects of HRQoL [6], particularly in obese women with NAFLD.…”

Section: Introductionmentioning

confidence: 99%

Comparative effects of two exercise training programs on health-related quality of life in middle-aged women with non-alcoholic fatty liver disease

Ahmad¹,

Ali²

2020

areh

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Background: Insufficient research exists on the effectiveness of exercise therapy in nonalcoholic fatty liver disease (NAFLD), particularly regarding the health-related quality of life (HRQoL) outcome. Therefore, this study aimed to assess the effects of high-intensity interval training (HIIT) compared to moderate-intensity combined resistance and aerobic training (RT/AT) on HRQoL in NAFLD patients. Material and methods: Twenty-three middle-aged obese women with NAFLD were enrolled in 3-month exercise interventions of either HIIT (n1 = 12, 46.3 ± 5 years, 40.5 ± 4.1 kg / m 2) or moderate-intensity combined RT/AT (n2 = 11, 45.6 ± 4.4 years, 43.5 ± 5.4 kg / m 2). Secondary hepatic steatosis, liver cirrhosis, or virus C hepatitis were excluded. HIIT was prescribed as 4 sets x 4 min at 80-85 % HRmax with 3 min active recovery. Combined RT/AT was prescribed as 10 min low to moderate cycling exercises followed by 8 resistance exercises at 50-75 % 1-RM. The outcomes were HRQoL, as assessed by the Chronic Liver Disease Questionnaire (CLDQ), and the percentage of body weight change (% ∆BW). Results: CLDQ domains were significantly improved in both HIIT & RT/AT groups compared to baselines; the emotional function & worry domains and the total CLDQ score were significantly higher in the HIIT group (p< 0.05)compared to the other group. Body weight was reduced by 13 % & 8 % in HIIT and combined RT/AT groups, respectively, with a significant difference in the % ∆ BW between the two groups in favor of HIIT. Conclusions: Both HIIT and moderate-intensity combined RT/AT could be suggested to improve the HRQoL and reduce body weight in middle-aged obese women with NAFLD, however, HIIT could be superior to the combined RT/AT in improving overall HRQoL, especially the emotional aspects, and reducing body weight.

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Quality of life in patients with nonalcoholic fatty liver disease: A systematic review

Cited by 37 publications

References 28 publications

Psychological Biomarkers and Fibrosis: An Innovative Approach to Non-alcoholic Fatty Liver Disease

Psychological Biomarkers and Fibrosis: An Innovative Approach to Non-alcoholic Fatty Liver Disease

Association between Non-Alcoholic Fatty Liver Disease and Dietary Habits, Stress, and Health-Related Quality of Life in Korean Adults

Comparative effects of two exercise training programs on health-related quality of life in middle-aged women with non-alcoholic fatty liver disease

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