Quality of Life in Patients With Parkinson’s Disease: A Cross-Sectional Study

Al-Khammash, Noora; Al-Jabri, Nujud; Albishi, Amal; Al-Onazi, Afaf; Aseeri, Sharifa; Alotaibi, Faisal; Almazroua, Yagob; Albloushi, Monirah

doi:10.7759/cureus.33989

Cited by 5 publications

(3 citation statements)

References 28 publications

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“…The analysis showed a mean difference of -12.13 (95% CI [-15.43, -8.83], p < 0.00001). A study conducted in Saudi Arabia revealed that several domain-based variables influenced the quality of life (QOL) of individuals with PD, including frequent hospitalizations, education level, and marriage status (Al-Khammash et al, 2023). A meta-analysis study found that PD patients had significantly poorer quality of life (QOL) compared to healthy controls, highlighting the need for effective measures to improve QOL in this patient population (Zhao et al, 2021).…”

Section: Quality Of Lifementioning

confidence: 99%

Probiotic Supplementation in Parkinson’s Disease

Nisa,

Amalisa,

Kristantya

et al. 2024

SMJ IDI Surabaya

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Background: Parkinson's disease (PD) is a prevalent neurodegenerative disease with both motor and non-motor symptoms. It has been postulated that dysbiosis and gut infections may have metabolic consequences that go unchecked and exacerbate the neurodegenerative process or peripheral inflammation in PD. Objective: This meta-analysis aims to elucidate the potential benefits of of probiotics as supplemental therapy for PD. Materials and Method: PRISMA 2020 was used for literature search. Multiple databases, such as PubMed, Science Direct, and CINAHL Plus, as well as Full Text, Sage Journals, and Web of Science, and clinical registries were investigated. The quality assessment and statistical analysis were conducted using the Jadad scale and the Review Manager software version 5.4.1. Results: Ten randomized controlled trials (RCTs) were included in this systematic review, six of which were quantitative studies. The results indicated that probiotic treatment significantly improved cognitive function based on the MMSE (mean difference [MD] = 0.4, 95% CI [-0.17, 0.97], I2 = 0%). Probiotic treatment also improved gastrointestinal symptoms as evidenced by the Bristol stool score (MD = 0.28, 95% CI [-0.40, 0.97], I2 = 93%) and the bowel movement score (MD = 1.25, 95% CI [0.74, 1.75], I2 = 0%). Significant effects were observed in the depression scale and quality of life, including the Patient Assessment of Constipation Quality of Life (PACQoL) and the Parkinson’s Disease Questionnaire (PDQ39). Conclusion: Probiotic supplementation significantly improved disease progression, gastrointestinal effects, mental health, and quality of life in patients with PD. This improvement may be attributed to a reduction in the inflammatory response and an increase in the activity of gut-brain axis.

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Section: Quality Of Lifementioning

confidence: 99%

Probiotic Supplementation in Parkinson’s Disease

Nisa,

Amalisa,

Kristantya

et al. 2024

SMJ IDI Surabaya

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“…Worsening motor functions, advanced stage of disease, and higher prevalence of falls may deteriorate the psychological aspects of QOL. There is a negative effect of depression on the QOL of patients with PD and depression is the most important determinant of QOL [5][6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Correlation Between Depression and Quality of Life Among Patients With Parkinson’s Disease: An Analytical Cross-Sectional Study

Sujith,

Arjunan,

Iype

et al. 2024

Cureus

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Introduction Parkinson’s disease (PD) is a progressive complex degenerative disorder characterised by several motor and non-motor symptoms that result in disability and deterioration of the patient's quality of life (QOL). Depression is the most common non-motor symptom that may severely alter the QOL. The objective of this study was to examine the correlation between depression and QOL among patients with PD who received treatment from a movement disorder clinic of a tertiary care teaching hospital in South India. Methods This was an analytical cross-sectional study conducted among 220 PD patients who received treatment from a movement disorder clinic of a tertiary care teaching hospital in South India. The participants aged between 40 and 80 years, who can comprehend Malayalam or English and were clinically diagnosed with PD according to United Kingdom PD Society Brain Bank criteria were included in the study. Depression was assessed using the Hospital Anxiety and Depression Scale, motor function using the Movement Disorder Society Unified Parkinson’s Disease Rating Scale Part III, and the quality of life was assessed using the Parkinson’s Disease Questionnaire 39. Results The results of this study showed that there was a significant positive correlation between depression and QOL (r=0.699, p<0.01) among patients with PD who received treatment from a tertiary care teaching hospital. The correlation with domains of QOL also identified that depression was significantly correlated with all domains of QOL and more to the emotional domain of QOL (r=0.799, p<0.01). Conclusion Depression is the most common neuropsychiatric condition in PD and the most important determinant of QOL. Depression may occur at any stage of PD and can significantly impact the QOL of patients and their caregivers. Hence it should be recognized early and managed by pharmacological and nonpharmacological measures to improve the QOL.

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“…Reported non-motor symptoms include autonomic and gastrointestinal problems, olfactory and sleep deficits, anxious and depressive symptoms, and cognitive impairment, among others [3,4]. Starting with mild symptoms, the disease gradually progresses to a level where daily activities and quality of life are negatively impacted [5].…”

Section: Introductionmentioning

confidence: 99%

An Ethnographic Study of Patient Life Experience in Early-Stage Parkinson’s Disease in the United States and Germany

Carmody,

Park,

Bennett

et al. 2024

Neurol Ther

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Introduction Existing qualitative research on early-stage Parkinson’s disease draws on patients’ reported disease experience, aiming to capture the symptoms and impacts most relevant to patients living with the disease. As a complement to this research, the present study investigated the patient experience of early-stage Parkinson’s disease from a holistic, ethnographic perspective. We explored the attitudes, beliefs, and social structures that shape how people understand and adapt to life with early-stage Parkinson’s disease. Methods Researchers interviewed 30 people with early-stage Parkinson’s disease, 10 relatives, and 10 neurologists and movement disorder specialists in the USA and Germany. Many of these interviews took place in-person, allowing researchers to spend time in participants’ homes and witness their daily lives. A multidisciplinary team of social scientists, clinical researchers, and patient organization representatives led the mixed-methods study design and analysis. In-depth ethnographic interviews yielded qualitative insights, with a quantitative survey following to assess their prevalence in a larger sample of 150 patients. Results In addition to developing a patient life experience pathway of early-stage Parkinson’s disease, we identified five key thematic findings that provide insight into how the clinical features of the disease become meaningful to patients on the context of their daily lives, family relations, and subjective well-being: (1) People with early-stage Parkinson’s disease start coming to terms with their disease before receiving a medical diagnosis; (2) Acceptance is not a finalized achievement, but a cyclical process; (3) People with early-stage Parkinson’s disease “live in the moment” to make the future more manageable; (4) Slowing disease progression is an important goal driving the actions of people with early-stage Parkinson’s; and (5) People with early-stage Parkinson’s disease value information that is grounded in lived experience and relevant to their stage of disease progression. Conclusion This holistic, ethnographic approach to patient life experience provided five key thematic findings that complement insights from qualitative and quantitative datasets on early-stage Parkinson’s disease. An enhanced understanding of how early-stage Parkinson’s symptoms impact patients’ health-related quality of life and their broader social lives can help us better understand how patients make decisions about their usage of healthcare services and therapies. Supplementary Information The online version contains supplementary material available at 10.1007/s40120-024-00632-7.

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Quality of Life in Patients With Parkinson’s Disease: A Cross-Sectional Study

Cited by 5 publications

References 28 publications

Probiotic Supplementation in Parkinson’s Disease

Probiotic Supplementation in Parkinson’s Disease

Correlation Between Depression and Quality of Life Among Patients With Parkinson’s Disease: An Analytical Cross-Sectional Study

An Ethnographic Study of Patient Life Experience in Early-Stage Parkinson’s Disease in the United States and Germany

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