Quality of life in patients with chronic cough

Young, Emma; Smith, Jaclyn A.

doi:10.1177/1753465809358249

Cited by 83 publications

(63 citation statements)

References 40 publications

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“…While there is no research focusing exclusively on the experience of cough in patients with lung cancer, studies conducted with chronic cough patients or those with other respiratory diseases such as asthma and chronic obstructive pulmonary disease suggest that cough is a distressing symptom with a significant impact on daily life [1,2]. Kelsall et al [3] recently found that chronic cough patients coughed an average 13.9 times/hour, with many coughing hundreds of times each day.…”

Section: Introductionmentioning

confidence: 98%

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The experience of cough in patients diagnosed with lung cancer

Molassiotis

Lowe

Ellis

et al. 2010

Support Care Cancer

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Section: Introductionmentioning

confidence: 98%

“…Numerous other effects of coughing, e.g. chest pains, rib fractures, hernia, stress incontinence, headaches and physical exhaustion, have been reported [2].…”

Section: Introductionmentioning

confidence: 99%

The experience of cough in patients diagnosed with lung cancer

Molassiotis

Lowe

Ellis

et al. 2010

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“…Chronic or dry cough is not a life-threatening disease in most of the cases but it affects seriously the healthcare budget and the quality of life [14][15][16]. This is a topical and multi-factorial pathology, requiring a pluri-targeted treatment approach [17].…”

Section: Discussionmentioning

confidence: 99%

Clinical Efficacy of Novel Filmogen, Antimicrobial, Cleaning, Fluidizing Cough Treatment

Shrivastava¹,

Carrois²,

Pisak³

et al. 2017

J Clin Trial

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Objective: Cough reflex is the body's protective mechanism to prevent entry of foreign material into the lower respiratory tract. Cough is usually caused by a primary viral infection: virus growth causes lysis of throat mucosa cells, leading to inflammation, secondary bacterial infection, accumulation of contaminants on the throat, increased mucus secretion, and coughing. To treat this multifactorial condition, an effective treatment should be multitarget, but no currently available drug fulfils this complex yet essential requirement. We developed a hypertonic, highly osmotic, filmogen liquid bandage which can mechanically clean the throat surface. A clinical trial was conducted to evaluate its efficacy and safety.Methods: A 14-day, randomized, placebo-controlled, double blind, efficacy and safety study was conducted on 37 treated vs. 17 comparator (saline solution) patients suffering from dry cough. Products were applied as spray, 3-4 times daily, for maximum 14 days, and cough-related parameters were evaluated on days 1, 2, 3, 6, 9, 12, and 14.Results: Compared to the comparator product, test product triggered an instant and strong reduction in the mean scores of dry cough severity and frequency, and consequently in throat pain, irritation, swelling, and redness, with remarkable improvement in Leicester cough questionnaire parameters. Test product proved as safe as the comparator product. Conclusions:Cleaning the throat surface and fluidizing mucus using a new generation of liquid throat bandages opens new therapeutic horizons for the treatment of severe cough.

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“…It is an essential protective and defensive action that secures the removal of mucus, noxious substances, and infections from the larynx, trachea, and larger bronchi (Chung, 2003). On the other hand, a number of patients have a non-productive cough, which is not associated with mucus clearance and may be the first overt sign of disease of the airways or lungs, may significantly contribute to the spread of airborne infections, and in some instances may result in severe functional and structural damage to the organism (for review, see Irwin et al, 2006;Brignall et al, 2008;Young & Smith, 2010).…”

Section: Introductionmentioning

confidence: 99%