Quality of life in multiple sclerosis and relationship to cognitive impairment

Câmara, Nair Assunta Antônia Corso; Obondzo, K.; Hantany, Y.; Mouni, F.Z.; Eddou, Hicham; Bouchra, E.M.; Abdo, R. Mohamed; Ilham, S.

doi:10.1016/j.jns.2017.08.693

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“…The association between cognitive deficits and QoL has been studied among different groups of patients including Alzheimer’s disease (AD), Parkinson’s disease, traumatic brain injury (TBI), and multiple sclerosis (MS) (Anderson et al, 2011; Leroi et al, 2012; Bosboom and Almeida, 2016; Camara et al, 2017). Previous studies have stated that cognitive deficits influence QoL by affecting the cognitive functions (such as memory) and reducing the learning skills and social and occupational performances (Barker-Collo et al, 2009; Ojeda et al, 2012).…”

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confidence: 99%

Efficacy of Neurocognitive Rehabilitation After Coronary Artery Bypass Graft Surgery in Improving Quality of Life: An Interventional Trial

et al. 2019

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Introduction Cognitive deficits are frequent after coronary artery bypass graft (CABG) surgery and consequently could lead to a decrease in quality of life. This is the first study that has been conducted with the aim of examining the efficacy of a computerized cognitive rehabilitation therapy (CCRT) in improving quality of life in patients after CABG surgery. Methods In this study, an interventional trial with pre-, post-, and follow-up assessments in active (CCRT), active control and control groups was conducted. Seventy-five patients after CABG surgery were selected and assigned to the groups ( n = 25 for each group). CCRT consists of four modules of attention, working memory, response inhibition and processing speed training with graded schedule in 20-min sessions three times per week within 8 weeks. Cognitive functions (attention and working memory) were assessed by the tests of continuous performance, Flanker, useful field of view and digit span at three time points: pre- and post-intervention (T0 and T1) and 6-month follow-up (T2). Quality of life was assessed by the SF-36 questionnaire at the same time points. The CCRT group received the cognitive rehabilitation for 2 months, active control group received a sham version of CCRT in an equal time duration and control group did not receive any cognitive intervention. Results Repeated measures analysis of variance (ANOVA) revealed a time by group interaction on cognitive functions, with CCRT producing a significant improvement at T1 ( p < 0.01) and these improvements were maintained at T2. Moreover, in CCRT and active control groups, quality of life (QoL) improved at T1 and these improvements remained stable throughout follow-up (T2). However, improvement of QoL in CCRT group was greater than improvement of QoL in the other two groups at T1. Pearson’s correlation analysis shows a positive correlation between QoL improvement and sustained attention and working memory enhancement ( p < 0.05). Conclusion Cognitive rehabilitation can lead to a significant improvement in the cognitive functions that have been trained in patients receiving CABG. Interestingly enough, cognitive rehabilitation can also improve quality of life in patients after CABG surgery and this improvement is maintained for at least 6 months.

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