Quality of Life in Long-Term Survivors of Testicular Cancer: A Population-Based Case-Control Study

Joly, Florence; Héron, J. F.; Kalusinski, L.; Bottet, P.; Brune, D.; Allouache, N.; Macé-Lesec'h, J; Couette, J.E.; Pény, J; Henry-Amar, Michel

doi:10.1200/jco.2002.20.1.73

Cited by 89 publications

(91 citation statements)

References 46 publications

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“…Prior studies [4][5][6][7][8][9][10][11][12] have suggested that the overall frequency of divorce in cancer patients (range, 5-17%) does not differ from that of well-matched controls in the general population. Our results are consistent with this observation, revealing an overall frequency of divorce (11.6%) in the 3 patient cohorts representing >500 patients diagnosed with serious neurologic and oncologic illnesses.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have in fact suggested that men are less able to undertake a caregiving role and assume the burdens of home and family maintenance compared with women. [3][4][5][6][7][8][9][10][11] Thus, a woman becomes willing sooner in the marriage to commit to the burdens of having a sick spouse.…”

Section: Discussionmentioning

confidence: 99%

“…[4][5][6][7][8][9][10][11][12] In our neuro-oncology practice, however, we were impressed by a striking gender asymmetry in the occurrence of divorce. Divorce appeared to occur almost exclusively when the wife was the disease-afflicted partner.…”

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confidence: 99%

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Gender disparity in the rate of partner abandonment in patients with serious medical illness

Glantz

Chamberlain

Liu

et al. 2009

Cancer

121

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The demand for increased formulation concentrations for protein therapeutics puts a significant strain on already existing tangential flow filtration (TFF) systems that were constructed with lower protein concentration targets as part of their design criteria. TFF is commonly used to buffer exchange and concentrate the product to the appropriate drug substance concentration. Analyzing the ability of an existing TFF system to process under conditions outside its original design specifications can be challenging. In this analysis, we present a systematic approach to assess the operational limits of a TFF process with consideration of system performance parameters for changing process targets. In two new engineering diagrams, the recovery efficiency diagram and the operating space plot, all relevant operational constraints and parameters are related to allow rapid process fit evaluation. The engineering assessment of TFF systems presented in this article allows a rational review of system limitations during process fit evaluations of existing TFF systems. It also provides a rational basis for targeted system upgrades and setting system design specifications for the design of new systems if existing systems are found inadequate. Biotechnol. Bioeng. 2012; 109: 3084–3092. © 2012 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Gender disparity in the rate of partner abandonment in patients with serious medical illness

Glantz

Chamberlain

Liu

et al. 2009

Cancer

121

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“…Some describe the influence on health-related QL (Fossa et al, 1999;Joly et al, 2002). Others show the necessarity of an open dialogue between doctors and patients on sexual difficulties (Bourgeois-Law and Lotocki, 1999;Hawighorst-Knapstein et al, 2002).…”

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confidence: 99%

Subjective quality of life and sexual functioning after germ-cell tumour therapy

et al. 2003

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Purpose: To evaluate the influence of germ-cell tumour therapy on sexual functioning and subjective quality of life (QL). To investigate the communication about sexual problems between patients, their partners, and doctors. In all, 474 patients treated for germ-cell tumours at the Department of Internal Medicine III, Ludwig-Maximilians-University Munich, from 1979 to 2000 were asked to complete a self-report questionnaire concerning psychosocial dimensions and subjective QL (QLS; Henrich and Herschbach, 2000). In total, 341 patients returned a completed questionnaire (response rate, 71.9%). The median age at survey was 41.9 years and the median follow-up period after therapy was 9.6 years. Persisting sexual sequelae were lower than in the current literature: decreased sexual desire (7.1%), erection (10.0%), orgasm (10.2%), ejaculation (28.8%), sexual activity (8.5%), and sexual satisfaction (4.8%). In QL the satisfaction with 'friends/acquaintances' (Po0.001) and 'family life/children' (Po0.001), is lower than in the healthy population. Correlations between functional scales and subjective QL were highly significant. There is a strong correlation between sexual satisfaction and global life satisfaction (Spearman's Rho: 0.48; Po0.01). A total of 61.4% of patients were not offered communication about sexual problems by their doctors and 21.2% were unable to talk with their partner about sexual issues. In conclusion, moderating psychosocial variables (e.g. personality factors, cognitive processes) should be investigated to clarify the relationship between life satisfaction (subjective QL) and functional impairments. Communication about sexual problems should be offered as a standard to patients treated for germ-cell tumours.

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“…Furthermore, there is a lack of research into the QoL of the growing group of long-term TCSs. Currently, there are only a few studies that did include long-term survivors [1,6,13,18], whereas at this point in time, approximately 25 years after the medical breakthrough in treatment, the group of long-term survivors has grown large enough to provide adequate statistical power to examine their QoL. Then again, the inclusion of long-term survivors does confront researchers with specific methodological concerns.…”

Section: Introductionmentioning

confidence: 99%

Quality of life of testicular cancer survivors and the relationship with sociodemographics, cancer-related variables, and life events

Fleer

Hoekstra

Sleijfer

et al. 2005

Support Care Cancer

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Quality of Life in Long-Term Survivors of Testicular Cancer: A Population-Based Case-Control Study

Cited by 89 publications

References 46 publications

Gender disparity in the rate of partner abandonment in patients with serious medical illness

Gender disparity in the rate of partner abandonment in patients with serious medical illness

Subjective quality of life and sexual functioning after germ-cell tumour therapy

Quality of life of testicular cancer survivors and the relationship with sociodemographics, cancer-related variables, and life events

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