Quality of Life in Inflammatory Bowel Disease: A Systematic Review and Meta-analyses—Part II

Knowles, Sandra R.; Graff, Lesley A; Wilding, Helen; Hewitt, Catherine; Keefer, Laurie; Mikocka‐Walus, Antonina

doi:10.1093/ibd/izy015

Cited by 214 publications

(111 citation statements)

References 83 publications

Supporting

Mentioning

100

Contrasting

Unclassified

Order By: Relevance

“…Disease onset is usually in adolescence/early-adulthood (15-35 years). Living with IBD may consequently be demanding and stressful, and it has been well demonstrated that IBD may negatively affect patients' health-related quality of life (HRQoL) [5,6].…”

Section: Introductionmentioning

confidence: 99%

Self-esteem in patients with inflammatory bowel disease

et al. 2020

View full text Add to dashboard Cite

Purpose The purpose of this study was to explore self-esteem and associations between self-esteem and sociodemographic, clinical, and psychological factors in patients with inflammatory bowel disease (IBD), a disease of chronic relapsing inflammation of the gastrointestinal tract. IBD symptoms, including pain, fatigue, and diarrhea, as well as potential lifelong medical treatment and surgery, may be demanding, cause significant challenges, and influence self-esteem. Methods In this cross-sectional multicenter study, participants were recruited from nine hospitals in the southeastern and western regions of Norway from March 2013 to April 2014. Data were collected using self-report questionnaires. Selfesteem was assessed by the Rosenberg Self-Esteem Scale, fatigue was assessed by the Fatigue Questionnaire, self-efficacy was assessed by the General Self-Efficacy Scale, and disease activity was assessed by the Simple Clinical Colitis Activity Index for ulcerative colitis (UC) and Harvey Bradshaw Index for Crohn's disease (CD). Multiple linear regression analysis was applied to examine associations between self-esteem and sociodemographic, clinical, and psychological factors. Results In total, 411 of 452 (91%) patients had evaluable data and were included in this study. The mean scores on selfesteem, self-efficacy, total fatigue, anxiety, and depression were similar between UC patients and CD patients. Male gender, being employed, and higher self-efficacy were independently associated with higher self-esteem, whereas anxiety and depression were independently associated with lower self-esteem. Neither disease activity nor fatigue were associated with self-esteem in the final multiple regression analyses. Conclusion Patient-centered interventions that improve self-esteem and reduce anxiety and depression seem to be important to optimize IBD management.

show abstract

Section: Introductionmentioning

confidence: 99%

Self-esteem in patients with inflammatory bowel disease

et al. 2020

View full text Add to dashboard Cite

show abstract

“…A recent systematic review and meta-analysis exploring quality of life among patients with IBD (i.e. UC and Crohn's disease (CD)) show that patients with IBD have worse healthrelated quality of life (HRQoL) than the general population, and patients with IBD have worse HRQoL in active disease states than during inactive disease 5,6 . However, the studies included in the systematic review and meta-analysis use different tools to measure HRQoL; many of the included studies have small sample sizes; and the populations are a mix of UC and CD patients.…”

Section: Introductionmentioning

confidence: 99%

Quality of life and patient preferences among Danish patients with ulcerative colitis – results from a survey study

Hagelund¹,

Stallknecht²,

Jensen³

2020

Current Medical Research and Opinion

View full text Add to dashboard Cite

Objective: To explore health-related quality of life (HRQoL) and assess preferences for medical treatment attributes to obtain information of the relative importance of the different attributes in a Danish population with ulcerative colitis (UC). Methods: We used data from an online survey collected in March 2018 among people with selfreported UC. A total of 302 eligible respondents answered the HRQoL questionnaires (EuroQol-5 Dimensions (EQ-5D-5L) and the Short Inflammatory Bowel Disease Questionnaire (SIBDQ)), and 212 also completed the discrete choice experiment (DCE). The probability of choosing an alternative from a number of choices in the DCE was estimated using a conditional logit model. Results: The respondents had an average SIBDQ score of 4.5 and an HRQoL score of 0.77, applying the EQ-5D-5L questionnaire. HRQoL correlated with disease severity, and the respondents had lower HRQoL than did a gender-and age-matched subset of the Danish population. The most important medical treatment attribute was efficacy within eight weeks. Additionally, respondents stated a preference for avoiding taking steroids, for fast onset of effect and for oral formulations. Conclusions: HRQoL correlates with disease severity, and patients with UC have lower HRQoL than the general population. The most important treatment attribute was efficacy, but patients also would like to avoid steroids, value fast onset of effect and prefer oral formulations. ARTICLE HISTORY

show abstract

“…Inflammatory bowel diseases (IBDs), of which Crohn's disease (CD) is a subtype, are chronic inflammatory conditions of the gastrointestinal tract with unpredictable periods of relapse and remission [1][2][3]. Due to disease symptoms such as abdominal pain, fever, diarrhea, anorexia, and anemia, as well as complications such as surgery, abscesses, fistulas, and stenosis, CD patients are vulnerable to experiencing psychosocial issues because of changes in many aspects of social and work life, which impacts their quality of life (QoL) and wellbeing [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

“…Nowadays, it is believed that the assessment of health-related QoL (HRQoL) is an important indicator of patient-reported outcomes [4,5]. Indeed, poorer social and interpersonal functioning, self-perception, and self-esteem are likely to be associated with CD-related complications such as chronic changes in bowel function, surgical scars, and ostomy, which in turn can adversely impact QoL.…”

Section: Introductionmentioning

confidence: 99%

Association between Health-Related Quality of Life and Nutritional Status in Adult Patients with Crohn’s Disease

et al. 2020

View full text Add to dashboard Cite

This study aimed to assess health related quality of life (HRQoL) in adult patients with Crohn’s disease (CD), considering disease severity and gender differences, and also its relationship with nutritional status. Consecutive adult patients aged 18–65 years with CD were recruited. Disease activity was clinically defined by the Crohn’s Disease Activity Index (CDAI) in active and quiescent phases. HRQoL was evaluated using the validated short form (SF)-36 questionnaire for the Italian population. Additionally, anthropometry, bioimpedance analysis, and handgrip-strength (HGS) were performed. Findings showed that 135 patients (79 men and 56 women) were included, having a mean age of 38.8 ± 14 years and a BMI of 23.2 ± 3.7 kg/m2. Overall, active CD patients had a lower perception of their QoL compared to those clinically quiescent, while gender differences emerged mostly in the quiescent group. Interestingly, HRQoL was significantly associated with many nutritional variables, and muscle strength was the main predictor. Therefore, HRQoL is perceived lower in active compared to quiescent patients, but women experienced poorer QoL than men, especially in the quiescent phase. Finally, higher QoL scores were found in subjects being in clinical remission phase with a preserved muscle function. However, further studies are still required to verify these findings.

show abstract

Quality of Life in Inflammatory Bowel Disease: A Systematic Review and Meta-analyses—Part II

Abstract: For adults in particular, there was strong confirmation that QoL is poorer during active disease and may be poorer for those with CD. The finding that QoL can improve over time may be encouraging for individuals with this chronic disease.

Cited by 214 publications

References 83 publications

Self-esteem in patients with inflammatory bowel disease

Self-esteem in patients with inflammatory bowel disease

Quality of life and patient preferences among Danish patients with ulcerative colitis – results from a survey study

Association between Health-Related Quality of Life and Nutritional Status in Adult Patients with Crohn’s Disease

Contact Info

Product

Resources

About