“…As such, a state of chronic inflammation associated with an elevation in inflammatory mediators may contribute to increase in glycated haemoglobin [ 12 , 16 , 19 , 20 ]. Many therapeutic strategies have been developed to improve periodontal conditions, among which ozone (O 3 ) is of specific concern [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 ]. Gaseous ozone (O 3 -triatomic oxygen) derives by the photodissociation of molecular O2 into activated oxygen atoms and reaction with further oxygen molecules.…”