Quality of Life in HIV Clinical Trials: Why Sexual Health Must Not Be Ignored

Koole, Olivier; Noëstlinger, Christiana; Colebunders, Robert

doi:10.1371/journal.pctr.0020008

Cited by 10 publications

(11 citation statements)

References 24 publications

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“…Encountering few ART-related side-effects contributed to normal physical and mental health [ 21 ]. Sexual dysfunction is an example of a side-effect – although frequently seen without iatrogenic cause – which was found to have a significant impact on HRQoL [ 42 ].…”

Section: Resultsmentioning

confidence: 99%

What determines health-related quality of life among people living with HIV: an updated review of the literature

2014

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BackgroundAs infection with the Human Immunodeficiency Virus (HIV) has evolved to a chronic disease, perceived health-related quality of life (HRQoL) is becoming a prominent and important patient-reported outcome measure in HIV care. Literature discusses different factors influencing HRQoL in this population, however, currently no consensus exists about the main determinants. In this review a clear, up-to-date overview of the determinants influencing HRQOL among people living with HIV is provided.MethodsAll studies published before July 2013 that identified determinants of HRQoL among people living with HIV in high-income countries, were considered in this narrative review. PubMed, Web of Science and The Cochrane Library were consulted using the keywords ‘determinants’, ‘quality of life’, ‘HIV’ and ‘AIDS’. To be included, studies should have reported overall health and/or physical/mental health scores on a validated instrument and performed multivariable regression analyses to identify determinants that independently influence perceived HRQoL.ResultsIn total, 49 studies were included for further analysis and they used a variety of HRQoL instruments: Medical Outcomes Study Short Form-36 or variants, Medical Outcomes Study-HIV, HIV Cost and Services Utilization Study measure, Multidimensional Quality of Life Questionnaire, HIV targeted quality of life instrument, Functional Assessment of Human Immunodeficiency Virus Infection, HIV Overview of Problems Evaluation System, EuroQol, Fanning Quality of Life scale, Health Index and PROQOL-HIV. In this review, the discussed determinants were thematically divided into socio-demographic, clinical, psychological and behavioural factors. Employment, immunological status, presence of symptoms, depression, social support and adherence to antiretroviral therapy were most frequently and consistently reported to be associated with HRQoL among people living with HIV.ConclusionsHRQoL among people living with HIV is influenced by several determinants. These determinants independently, but simultaneously impact perceived HRQoL. Most HRQoL instruments do not capture all key determinants. We recommend that the choice for an instrument should depend on the purpose of the HRQoL assessment.Electronic supplementary materialThe online version of this article (doi:10.1186/2049-3258-72-40) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

What determines health-related quality of life among people living with HIV: an updated review of the literature

2014

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“…Experiencing few ART-related side-effects associated to normal physical and mental health [43]. One of the examples of side-effects to be mentioned is sexual dysfunction which has a major effect on HRQoL even thogh frequently seen without iatrogenic reason [44].…”

Section: Discussionmentioning

confidence: 99%

Clinical determinants associated with quality of life for people who live with HIV/AIDS: a Meta-analysis

Ghiasvand

Waye

Noroozi

et al. 2019

BMC Health Serv Res

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BackgroundDuring recent years, Quality of Life (QoL) is a significant assessment factor in clinical trials and epidemiological researches due to the advent of Antiretroviral Therapy (ART), Human Immunodeficiency Virus (HIV) has become a manageable,chronic disease. With regards, more attention must be paid to the QoL of infected patients. Limited evidence exists on the impact of ART on QoL among HIV infected patients. Due to lacking of a systematic approach to summarizing the available evidence on the clinical determinants of People Who Live with HIV/AIDS (PWLHs’) QoL, this study aimed to analyze the impact of clinical determinants (ART experience, CD4 count < 200, co-morbidities, time diagnosis and accessibility to cares) on QoL among PWLHs’.MethodsThis study was designed in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). PubMed, Science Direct, Web of Science, and Cochrane electronic databases were searched in February 2017 to identify all past studies that discussed social and behavioral characteristics of QoL in PLWHA. To recognize effective factors on social and behavioral QoL, a meta-analysis was conducted. Polled Odds Ratios (ORs) were utilized at a 95% confidence level. Since sampling methods differed between articles in the systematic review, we evaluated pooled estimates using a random effect model. Metan, metareg, metacum, and metabias commands in STATA version 13.0 were applied to analyze the data.ResultsOur findings indicated that ART has a positive impact on QoL, with a pooled effect size at approximately 1.04 with a confidence interval between 0.42 to 1.66 which indicates this impact is not very considerable and may be relatively neutral. The pooled effect size for CD4 count on QoL was .29 (95%CI = .22–.35), indicating that there is a negative associate between CD4 count and QoL. The co-morbidity as a negative determinant for QoL among HIV/AIDS infected people. The pooled effect size implies on a relative neutral association, although the confidence interval is wide and ranges between 0.32 to 1.58. The pooled effect size is about 1.82 with confidence interval 1.27 to 2.37 which indicates a considerable positive association with lowest level of heterogeneity.ConclusionsThe results illustrated that time diagnosing and availability to hospital services had significant relationship with a higher QoL and CD4 < 200 was associated with a lower QoL. In conclusion, policy makers should set an agenda setting to provide a suitable diagnostic and therapeutic facilities to early detecting and continues monitoring the health status of People Who Live with HIV/AIDS (PWLHs’).

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“…4 Further, SQoL is part of, and associated with overall health-related quality of life. 5 Factors associated with SQoL have largely been studied among elderly populations and those with illness. Factors associated with decreased sexual functioning and SQoL include physiologic, medical, and psychological factors, such as medication use, 4 depression and substance abuse, 6 herpes simplex virus (HSV)-2 infection, 7,8 and HIV infection.…”

Section: Introductionmentioning

confidence: 99%

Sexual Quality of Life and Association With HIV and Sexually Transmitted Infections Among a Cohort of Heterosexual Couples in Kenya

Mehta

Nordgren

Agingu

et al. 2018

The Journal of Sexual Medicine

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Quality of Life in HIV Clinical Trials: Why Sexual Health Must Not Be Ignored

Cited by 10 publications

References 24 publications

What determines health-related quality of life among people living with HIV: an updated review of the literature

What determines health-related quality of life among people living with HIV: an updated review of the literature

Clinical determinants associated with quality of life for people who live with HIV/AIDS: a Meta-analysis

Sexual Quality of Life and Association With HIV and Sexually Transmitted Infections Among a Cohort of Heterosexual Couples in Kenya

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