Quality of life in a German cohort of Parkinson’s patients assessed with three different measures

Balzer‐Geldsetzer, Monika; Dodel, Richard; Riedel, Oliver

doi:10.1007/s00415-018-9047-9

Cited by 18 publications

(15 citation statements)

References 41 publications

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“…Despite these results, studies including patients in more advanced stage of PD are still needed for a better understanding of this relationship. Balzer-Geldsetzer et al (2018) also observed relationship between higher MI assessed by the HY scale and worse global quality of life as well as in some of the domains of quality of life (i.e., mobility, activities of daily live, emotional well-being, cognition, and communication domains) in patients with mild to moderate PD. However, although previous studies (He et al, 2016;Rosqvist et al, 2021) have also observed relationship between higher MI and worse global quality of life in patients with advanced PD, they did not assess the different domains of quality of life.…”

Section: Introductionmentioning

confidence: 62%

Influence of motor impairment on exercise capacity and quality of life in patients with Parkinson disease

et al. 2021

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This study evaluated the impact of motor impairment (MI) on exercise capacity and quality of life in patients with Parkinson disease (PD). One hundred ninety-two patients (≥50 years old) were divided according to the Hoehn and Yahr stages in: mild (stage I), mild to moderate (stage II), moderate (stage III), and advanced MI (stage IV). Exercise capacity (6-min walk test [6MWT]) and quality of life (Parkinson’s Disease Questionnaire [PDQ-39]) were obtained. In this context, 6MWT was progressively worse with increasing the severity of MI (P<0.01). Patients with advanced MI achieved 39% of predicted 6MWT of healthy subject, while subjects with mild MI achieved 83% of healthy subject (P<0.01). In addition, patients with advanced MI presented higher (i.e., worse) PDQ-39 scores in summary index, cognition, mobility and activities of daily live domains compared to other groups (P<0.01). Patients with moderate MI also presented worse scores in PDQ-39 summary index, mobility and activities of daily live domains in comparison with mild MI patients (P<0.01). Higher MI was correlated with worse exercise capacity (6MWT: r=-0.46, P<0.01), with worse PDQ-39 summary index and the mobility and activities of daily live domains scores (r=0.38, r=0.46, and r=0.43, P<0.01). In conclusion, MI is related to lower exercise capacity and quality of life (i.e., PDQ-39 summary index and mobility and activities of daily live domains) in patients with PD.

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Section: Introductionmentioning

confidence: 62%

Influence of motor impairment on exercise capacity and quality of life in patients with Parkinson disease

et al. 2021

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“…However, female gender proved to be a negative predictor for physical-functioning and socioemotional HrQoL, whereas male gender mainly affected the HrQoL cognition domain. Conversely, in a prospective study on a cohort of patients with idiopathic PD in Germany, female patients reported more problems in all dimensions, except selfcare [40]. At the same time, a longitudinal study designed to analyze the effect of PD onset on life satisfaction showed marked reduction of life satisfaction among individuals in the second half of life in men, but not in women [41].…”

Section: Quality Of Lifementioning

confidence: 88%

Parkinson’s Disease in Women and Men: What’s the Difference?

Cerri¹,

Mus²,

Blandini³

2019

JPD

450

309

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Increasing evidence points to biological sex as an important factor in the development and phenotypical expression of Parkinson's disease (PD). Risk of developing PD is twice as high in men than women, but women have a higher mortality rate and faster progression of the disease. Moreover, motor and nonmotor symptoms, response to treatments and disease risk factors differ between women and men. Altogether, sex-related differences in PD support the idea that disease development might involve distinct pathogenic mechanisms (or the same mechanism but in a different way) in male and female patients. This review summarizes the most recent knowledge concerning differences between women and men in PD clinical features, risk factors, response to treatments and mechanisms underlying the disease pathophysiology. Unraveling how the pathology differently affect the two sexes might allow the development of tailored interventions and the design of innovative programs that meet the distinct needs of men and women, improving patient care.

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“…In addition, some studies found that REM sleep behavior disorder with reduced striatal dopamine transporter values and increased expression of PD‐related pattern may be associated with the occurrence of PD 65‐67 . The discrepancy between studies could be partly due to differences in instruments, 68,69 sampling methods, disease severity, 14,70 effects of treatments, 71‐75 cognitive performance, 76 and clinical presentations caused by different associated genes 77 . The limited number of studies with the same QOL measure precluded an analysis of the moderating effects of the abovementioned demographic and clinical characteristics on QOL in PD.…”

Section: Discussionmentioning

confidence: 99%

Quality of life in Parkinson's disease: A systematic review and meta‐analysis of comparative studies

et al. 2020

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Background Studies regarding the impact of Parkinson's disease (PD) on quality of life (QOL) have reported conflicting results, and the underlying QOL domains require further study. In order to understand the association between PD and QOL, we conducted this meta‐analysis to systematically compare QOL between PD patients and healthy controls. Method The PubMed, PsycINFO, EMBASE, and Web of Science databases were systematically searched. Data were analyzed using the random‐effects model. Results Twenty studies covering 2707 PD patients and 150,661 healthy controls were included in the study. Compared with healthy controls, PD patients had significantly poorer QOL overall and in most domains with moderate to large effects sizes. Different QOL measures varied in their association with quality of life, with the Parkinson's Disease Questionnaire‐39 (PDQ‐39) having the largest effect size (standard mean difference, SMD = −1.384, 95% CI: −1.607, −1.162, Z = 12.189, P < 0.001), followed by the Europe Quality of Life Questionnaire‐visual analogue scale (EQ‐VAS) (SMD = −1.081, 95% CI: −1.578, −0.584, Z = −4.265, P < 0.001), Europe Quality of Life Questionnaire‐5D (EQ‐5D) (SMD = −0.889, 95% CI: −1.181, −0.596, Z = −5.962, P < 0.001), and the Short‐form Health Survey (SF) scales (physical dimension: SMD = −0.826, 95% CI: −1.529, −0.123, Z = −2.303, P = 0.021; mental dimension: SMD = −0.376, 95% CI: −0.732, −0.019, Z = −2.064, P = 0.039). Conclusion PD patients had lower QOL compared with healthy controls in most domains, especially in physical function and mental health. Considering the negative impact of poor QOL on daily life and functional outcomes, effective measures should be developed to improve QOL in this population.

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Quality of life in a German cohort of Parkinson’s patients assessed with three different measures

Cited by 18 publications

References 41 publications

Influence of motor impairment on exercise capacity and quality of life in patients with Parkinson disease

Influence of motor impairment on exercise capacity and quality of life in patients with Parkinson disease

Parkinson’s Disease in Women and Men: What’s the Difference?

Quality of life in Parkinson's disease: A systematic review and meta‐analysis of comparative studies

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